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Adverse Side Effects of Crizotinib in the Treatment of Anaplastic Lymphoma Kinase-Mutated Non-small Cell Lung Cancer: A Systematic Review.

Author: AbazaAbdelrahman, AliMarya, AliZahra, GeorgeSherie, GutlapalliSai Dheeraj, HamidPousette, JamilAneeque, ObleMrinal J P, ShahiSrushti R, SoniaShamsun Nahar

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Crizotinib is an ALK inhibitor used to treat ALK-mutated advanced NSCLC. While it has a better side effect profile than chemotherapy, it can still cause side effects such as liver dysfunction, nausea, neutropenia, and QT prolongation. These side effects can lead to treatment discontinuation or dose reduction.
Paper Details　
Original Abstract of the Article :
Lung cancer is the leading cause of cancer deaths worldwide, with the majority consisting of non-small cell lung cancer (NSCLC). Genetic mutations present an opportunity for targeted therapy, in addition to current mainstay treatments such as chemotherapy and radiotherapy. Overall, 5% of NSCLCs have...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585412/

データ提供：米国国立医学図書館（NLM）

Crizotinib's Side Effects in Treating ALK-Mutated Lung Cancer

This research examines the adverse side effects of crizotinib, a targeted therapy used to treat anaplastic lymphoma kinase (ALK)-mutated non-small cell lung cancer (NSCLC). It's like studying the potential dangers of a desert oasis, where lush vegetation and water can also harbor hidden risks! The study analyzed data from various clinical trials and found that while crizotinib is generally well-tolerated, it can have some serious side effects, such as liver dysfunction, neutropenia, and QT prolongation.

Crizotinib's Side Effect Profile: A Balance of Benefits and Risks

This study found that crizotinib can have a positive impact on ALK-mutated NSCLC, but it also highlights the need to carefully monitor patients for potential side effects. The authors emphasize that while crizotinib's side effect profile is generally better than chemotherapy, it's crucial to be aware of these potential risks and to adjust treatment accordingly. This is like being mindful of the dangers of the desert oasis, while appreciating its benefits for survival and rejuvenation.

Managing Crizotinib's Side Effects for Optimal Treatment

This research underscores the importance of careful monitoring and management of crizotinib's side effects to ensure optimal treatment for patients with ALK-mutated NSCLC. It's like navigating the desert with a skilled guide, who can recognize and address potential risks along the way, ensuring a safe and successful journey.

Dr. Camel's Conclusion

This study provides valuable insights into the side effect profile of crizotinib, a targeted therapy for ALK-mutated NSCLC. It's like navigating a desert oasis, where the benefits must be carefully weighed against the potential risks. By understanding these risks and implementing effective management strategies, we can optimize treatment for patients with this challenging condition and ensure their safety and well-being.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-10-30
Further Info :

Pubmed ID

37868485

DOI: Digital Object Identifier

PMC10585412

SNS
PICO Info
in preparation
Languages

English

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