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Calcifediol: Mechanisms of Action.

Author: AuriliaCinzia, BrandiMaria Luisa, DonatiSimone, FalsettiIrene, GiustiFrancesca, IantomasiTeresa, MariniFrancesca, PalminiGaia

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Calcifediol, a precursor to calcitriol, the active form of vitamin D, has a vital role in calcium and phosphate homeostasis. Calcifediol binds to the vitamin D receptor (VDR) and can trigger both genomic and non-genomic responses. While its genomic effects are well-understood, recent research highlights the rapid non-genomic effects mediated through interactions with membrane-associated VDR (mVDR) and protein disulfide isomerase family A member 3 (Pdia3). This paper explores the diverse mechanisms of action of calcifediol and their potential implications for treating vitamin D deficiency-related diseases.
Paper Details　
Original Abstract of the Article :
Due to its essential role in calcium and phosphate homeostasis, the secosteroid hormone calcitriol has received growing attention over the last few years. Calcitriol, like other steroid hormones, may function through both genomic and non-genomic mechanisms. In the traditional function, the interacti...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610216/

データ提供：米国国立医学図書館（NLM）

Calcifediol: A Camel's Perspective on Vitamin D's Mechanisms of Action

The realm of [Vitamin D] is a fascinating one, with this essential nutrient playing a crucial role in our health. This study explores the [Mechanisms of Action] of [Calcifediol], a precursor to the active form of vitamin D. It's like uncovering the hidden pathways through which a vital desert plant influences the ecosystem.

Unveiling the Secrets: A Camel's Journey into Calcifediol's Actions

The researchers describe both [Genomic] and [Non-Genomic] mechanisms through which calcifediol exerts its effects. Calcifediol binds to the [Vitamin D Receptor (VDR)], influencing gene transcription and triggering rapid cellular responses. It’s like a desert plant that influences the growth and function of surrounding organisms through both long-term and immediate processes. This research sheds light on the complex and multifaceted nature of vitamin D’s actions in the body.

A Vital Nutrient: A Camel's Advice on Vitamin D

This study underscores the importance of understanding the mechanisms by which vitamin D influences our health. It’s like appreciating the intricate web of life in the desert ecosystem, where even a seemingly simple plant can have profound effects. This research is a reminder of the vital role vitamin D plays in maintaining our well-being.

Dr. Camel's Conclusion

This study reveals the intricate mechanisms by which calcifediol, a precursor to the active form of vitamin D, influences our health. By understanding these intricate pathways, we can better appreciate the vital role vitamin D plays in maintaining our well-being. It’s a reminder that even in the vast desert of our bodies, there are hidden oases of knowledge waiting to be discovered.

Date :
  1. Date Completed 2023-10-30
  2. Date Revised 2023-10-30
Further Info :

Pubmed ID

37892484

DOI: Digital Object Identifier

PMC10610216

Related Literature

Article Analysis
・Effects of calcifediol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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