Effects of calcifediol: A Synthesis of Findings from 25 Studies

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Original Abstract of the Article

Major Research Findings

Calcifediol, the direct precursor of the active form of vitamin D3, has shown promising effects in various studies. One notable finding is its ability to rapidly increase serum vitamin D levels, offering a faster alternative to traditional vitamin D3 supplementation. 1 Additionally, calcifediol has demonstrated positive effects on bone health, particularly in individuals with osteoporosis, renal osteodystrophy, and secondary hyperparathyroidism. 10 、 9 、 19 Research also suggests that calcifediol plays a role in immune modulation and may be beneficial in managing conditions like atopic dermatitis and systemic lupus erythematosus. 4 、 23 Furthermore, calcifediol supplementation has shown potential to improve lactation performance in dairy cows by increasing milk yield and colostrum production. 16

Benefits and Risks

Benefits Summary

Calcifediol has shown potential benefits in various aspects of health, including:

  • Rapidly increasing serum vitamin D levels
  • Improving bone health in conditions like osteoporosis, renal osteodystrophy, and secondary hyperparathyroidism
  • Potentially modulating the immune system and offering benefits in conditions like atopic dermatitis and systemic lupus erythematosus
  • Improving lactation performance in dairy cows by increasing milk yield and colostrum production
1 、 10 、 9 、 19 、 4 、 23 、 16

Risks Summary

While calcifediol offers potential benefits, it is important to note that it may increase serum calcium levels. 10

Comparison Across Studies

Commonalities Across Studies

Multiple studies consistently highlight the effectiveness of calcifediol in addressing vitamin D deficiency. Across various populations and applications, calcifediol has demonstrated its ability to elevate serum vitamin D levels and exert beneficial effects on bone metabolism and immune function. 16 、 25 、 5 、 14 、 13 、 17 、 1 、 6

Differences Across Studies

The effects of calcifediol may vary depending on factors such as dosage, target population, and the specific condition being addressed. For instance, in dairy cows, the amount of calcifediol supplementation influenced milk production and serum calcium levels. 16 Similarly, the effectiveness of calcifediol in treating osteoporosis might be influenced by the specific type of alendronate used concurrently. 9

Consistency and Contradictions in Results

While research consistently supports the use of calcifediol in addressing vitamin D deficiency, there are variations in its effectiveness depending on dosage, population, and specific condition being treated. Further research is needed to establish the optimal dosages and applications for calcifediol. 16 、 25 、 5 、 14 、 13 、 17 、 1 、 6 、 9

Cautions for Real-World Applications

While calcifediol holds promise for managing vitamin D deficiency, it is crucial to avoid self-medication. It's essential to consult a physician for appropriate dosage and guidance, as calcifediol can potentially increase serum calcium levels and interact with other medications. Regular monitoring of serum calcium levels is also recommended when taking calcifediol. 10

Limitations of Current Research

Further research is essential to gain a deeper understanding of the full range of calcifediol's effects. More comprehensive clinical trials are needed, taking into account varying dosages, populations, and disease conditions. Additionally, long-term safety studies are crucial to assess the potential risks associated with prolonged calcifediol use. 16 、 25 、 5 、 14 、 13 、 17 、 1 、 6 、 9

Future Research Directions

Future research should focus on conducting comprehensive clinical trials with varying dosages and populations to fully characterize the effects of calcifediol. Long-term safety and efficacy studies are crucial to understand the potential risks and benefits of prolonged calcifediol use. Additionally, research is needed to investigate potential drug interactions and the effects of calcifediol on pregnant and breastfeeding women. 16 、 25 、 5 、 14 、 13 、 17 、 1 、 6 、 9

Conclusion

Calcifediol holds promise as a potential therapeutic agent for vitamin D deficiency. However, its effectiveness can vary depending on factors like dosage, target population, and the specific condition being addressed. It's crucial to consult a physician for appropriate guidance and dosage, as calcifediol can potentially interact with other medications and may increase serum calcium levels. More research is needed to comprehensively understand the full spectrum of calcifediol's effects, particularly in long-term use. 16 、 25 、 5 、 14 、 13 、 17 、 1 、 6 、 9

Literature analysis of 25 papers
Positive Content
25
Neutral Content
0
Negative Content
0
Article Type
3
2
2
5
25
1.

Effects of Weekly Supplementation of Cholecalciferol and Calcifediol Among the Oldest-Old People: Findings From a Randomized Pragmatic Clinical Trial.

Author: RuggieroCarmelinda, BaroniMarta, BiniVittorio, BrozzettiAnnalisa, ParrettiLuca, ZengariniElisa, LapennaMaria, AntinolfiPierluigi, FalorniAlberto, MecocciPatrizia, BoccardiVirginia

Improved vitamin D levels

This study looked at the effects of vitamin D supplements (D3 or 25D3) in very elderly individuals. Both types of vitamin D increased levels of 25(OH)D and 1-25(OH)D in the blood, with 25D3 showing a faster improvement. While both supplements also lowered levels of parathyroid hormone (iPTH) and C-reactive protein (CRP), those taking many medications or with weak handgrip strength were less likely to see their vitamin D levels improve.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Calcifediol versus vitamin D3 effects on gait speed and trunk sway in young postmenopausal women: a double-blind randomized controlled trial.

Author: MeyerO, Dawson-HughesB, SidelnikovE, EgliA, GrobD, StaehelinH B, TheilerG, KressigR W, SimmenH P, TheilerR, Bischoff-FerrariH A

Gait speed improvement

This double-blind randomized controlled trial (RCT) compared the effects of calcifediol and vitamin D3 on gait speed in young postmenopausal women. Calcifediol improved gait speed by 18% compared to vitamin D3, and changes in 25(OH)D blood levels were significantly correlated with improvements in gait speed.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Calcifediol: Why, When, How Much?

Author: DonatiSimone, MariniFrancesca, GiustiFrancesca, PalminiGaia, AuriliaCinzia, FalsettiIrene, IantomasiTeresa, BrandiMaria Luisa

Bone health
Calcium homeostasis
Improved vitamin D status

This review explores the potential medical benefits of calcifediol (25(OH)D3) as an oral vitamin D supplement. Calcifediol, the direct precursor of the biologically active form of vitamin D3, offers rapid non-genomic responses and may be particularly effective in restoring serum 25(OH)D3 levels in individuals at higher risk of hypovitaminosis D.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Vitamin D attenuates DNCB-induced atopic dermatitis-like skin lesions by inhibiting immune response and restoring skin barrier function.

Author: LuRenwei, PengZiqi, LianPanpan, WazirJunaid, GuChaode, MaChujun, WeiLulu, LiLi, PuWenyuan, LiuJun, WangHongwei, SuZhonglan

Calcifediol AD protection
Reduced inflammation
Restored skin barrier

Calcifediol, a vitamin D metabolite, was found to protect mice against atopic dermatitis (AD) by reducing inflammation and restoring skin barrier function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Effects of calcifediol supplementation on markers of chronic kidney disease-mineral and bone disorder in dogs with chronic kidney disease.

Author: ParkerValerie J, RudinskyAdam J, BenedictJason A, BeizaeiAzadeh, ChewDennis J

Improved CKD-MBD
Increased vitamin D
None reported

Calcifediol supplementation, administered for 84 days to dogs with chronic kidney disease, was well-tolerated and resulted in significant improvements in serum vitamin D metabolites.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

In Vitro Non-Genomic Effects of Calcifediol on Human Preosteoblastic Cells.

Author: DonatiSimone, PalminiGaia, RomagnoliCecilia, AuriliaCinzia, MigliettaFrancesca, FalsettiIrene, MariniFrancesca, ZonefratiRoberto, GalliGianna, MarcucciGemma, IantomasiTeresa, BrandiMaria Luisa

Ca2+ mobilization

This study investigated the non-genomic effects of calcifediol [25(OH)D3], a precursor of vitamin D3, on human adipose tissue-derived mesenchymal stem cells (hADMSCs). The study found that 25(OH)D3 can induce a rapid increase in intracellular calcium levels, similar to the active form of vitamin D3.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

Paricalcitol and Extended-Release Calcifediol for Treatment of Secondary Hyperparathyroidism in Non-Dialysis Chronic Kidney Disease: Results From a Network Meta-Analysis.

Author: FranchiMatteo, GunnarssonJoel, Gonzales-ParraEmilio, FerreiraAnibal, StrömOskar, CorraoGiovanni

PTH reduction
Calcium increase

Extended-release calcifediol (ERC) is comparable to paricalcitol (PCT) in lowering PTH levels. ERC avoids potentially clinically relevant increases in serum calcium, making it an effective and well-tolerated treatment option for secondary hyperparathyroidism in patients with non-dialysis CKD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

8.

Bariatric surgery and calcifediol treatment, Gordian knot of severe-obesity-related comorbidities treatment.

Author: Herrera-MartínezAura D, Castillo-PeinadoLaura L S, Molina-PuertaMaría J, Calañas-ContinenteAlfonso, MembrivesAntonio, CastillaJuan, Camacho CardenosaMarta, Casado-DíazAntonio, Gálvez-MorenoMaría A, GaheteManuel D, Quesada GómezJosé Manuel, BouillonRoger, Priego-CapoteFeliciano, LuqueRaúl M

Improved metabolic comorbidities

Vitamin D supplementation after bariatric surgery (BS) in obese patients reduced inflammation and improved metabolic comorbidities, which was associated with significant changes in the molecular expression of key inflammasome-machinery components.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Effects of alendronate and calcifediol compared to alendronate and cholecalciferol in osteoporotic patients.

Author: GiampàEmiliano, Di BonitoMario, FerrettiValentino, NuvoliGiuseppe, PaolettiFranco, PiazziniMarco, RanieriMauro, TuveriMarco A, VinicolaVincenzo

Osteoporosis treatment
Adverse reactions

This study examined the efficacy and safety of calcifediol (25(OH)D) compared to cholecalciferol (vitamin D3) in treating osteoporosis. The study also investigated the relationship between different formulations of alendronate and adverse reactions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

10.

[Extended release calcifediol and paricalcitol in the treatment of secondary hyperparathyroidism: a network meta-analysis of indirect comparison].

Author: FranchiMatteo, GalassiAndrea, CorraoGiovanni

Effective treatment
PTH reduction
Calcium increase
Increased serum FGF-23
Increased serum calcium
Increased serum phosphate

This meta-analysis compares the effects of extended release calcifediol (ERC) and paricalcitol (PCT) in controlling parathyroid hormone (PTH) and calcium levels in patients with secondary hyperparathyroidism (SHPT) caused by chronic kidney disease (CKD). Both ERC and PCT effectively reduced PTH levels, but calcium levels tended to increase with PCT treatment. ERC may be a more tolerable alternative to PCT.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Italian

12.

Changes in miRNA expression in the lungs of pigs supplemented with different levels and forms of vitamin D.

Author: WierzbickaAlicja, Pawlina-TyszkoKlaudia, ŚwiątkiewiczMałgorzata, SzmatołaTomasz, OczkowiczMaria

Immunomodulatory effects

This study aims to understand the effect of vitamin D supplementation on gene expression in healthy swine lungs by analyzing the miRNA profile after different doses of cholecalciferol and calcidiol.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Long-Term Treatment and Effect of Discontinuation of Calcifediol in Postmenopausal Women with Vitamin D Deficiency: A Randomized Trial.

Author: Pérez-CastrillónJosé Luis, Dueñas-LaitaAntonio, Gómez-AlonsoCarlos, JódarEsteban, Del Pino-MontesJavier, BrandiMaria Luisa, Cereto CastroFernando, Quesada-GómezJosé Manuel, Gallego LópezLaura, Olmos MartínezJosé Manuel, Alhambra ExpósitoMaría Rosa, GalarragaBernat, González-MacíasJesús, NeyroJosé Luis, BouillonRoger, Hernández-HerreroGonzalo, Fernández-HernandoNieves, ChinchillaSandra P

Stable 25(OH)D levels
Vitamin D deficiency treatment

This clinical trial compared the efficacy and safety of monthly calcifediol 0.266 mg versus cholecalciferol 25,000 IU in postmenopausal women with vitamin D deficiency. The study found that long-term treatment with monthly calcifediol was effective and safe, producing stable and sustained 25(OH)D concentrations with no associated safety concerns. Calcifediol had a faster onset of action compared to cholecalciferol.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Efficacy, safety, and dose-response effects of calcifediol supplementation on 25-hydroxyvitamin D, parathyroid hormone, and 1,25-dihydroxyvitamin D levels in healthy adults: An open-label, interventional pilot study.

Author: DasLiza, HolickMichael F, SachdevaNaresh, BhadadaSanjay Kumar, SinghmarShallu, ThakurNeetika, DuttaPinaki, MarwahaRaman Kumar

VDD treatment

This study aims to evaluate the effects of calcifediol (25-hydroxyvitamin D3) on 25(OH)D, PTH, and 1,25(OH)2D levels in healthy adults, particularly at higher doses.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

Vitamin D Deficiency in COVID-19 Patients and Role of Calcifediol Supplementation.

Author: MingianoChristian, PicchioniTommaso, CavatiGuido, PirrottaFilippo, CalabreseMarco, NutiRanuccio, GonnelliStefano, FortiniAlberto, FredianiBruno, GennariLuigi, MerlottiDaniela

Improves prognosis
Reduces hospitalization

Hypovitaminosis D has been associated with worse outcomes in respiratory tract infections, including COVID-19. This study evaluated the relationship between vitamin D levels and COVID-19 severity, mortality, and mechanical ventilation needs in hospitalized patients. The study also analyzed the potential benefits of calcifediol supplementation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

The effects of calciferol and its metabolites on patients with chronic renal failure. I. Calciferol, dihydrotachysterol, and calcifediol.

Author: VoigtsA L, FelsenfeldA J, LlachF

Improved bone health
Liver disease

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

23.

Darkness hormone or daylight hormone in women with systemic lupus erythematosus?

Author: BilginMelek, KeskinAdem, AciRecai, BaklaciogluHatice Sule, Arslanbek ErdemMukadder

Immune modulation
SLE

This study of 56 women with systemic lupus erythematosus (SLE) found that women with SLE had lower melatonin and 25-hydroxyvitamin D3 levels than healthy women.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

24.

Rapid Nontranscriptional Effects of Calcifediol and Calcitriol.

Author: DonatiSimone, PalminiGaia, AuriliaCinzia, FalsettiIrene, MigliettaFrancesca, IantomasiTeresa, BrandiMaria Luisa

Vitamin D non-genomic effects

Vitamin D, beyond its traditional role in calcium and phosphate homeostasis, exerts rapid, non-genomic actions through membrane receptors, including VDRm and Pdia3. Understanding these non-genomic effects may lead to the identification of novel therapeutic targets for modulating vitamin D actions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

25.

25-hydroxyvitamin D<sub>3</sub> generates immunomodulatory plasticity in human periodontal ligament-derived mesenchymal stromal cells that is inflammatory context-dependent.

Author: BehmChristian, BlufsteinAlice, GahnJohannes, MoritzAndreas, Rausch-FanXiaohui, AndrukhovOleh

Immunomodulation

Human periodontal ligament-derived mesenchymal stromal cells (hPDL-MSCs) interact with CD4+ T lymphocytes, and their immunomodulatory abilities can be enhanced by pro-inflammatory cytokines. This study aims to investigate the influence of 25-hydroxyvitamin D3 on the interaction between hPDL-MSCs and CD4+ T lymphocytes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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