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Polyploid cell dynamics and death before and after PEG-treatment of a NIH/3T3 derived culture: vinblastine effects on the regulation of cell subpopulations heterogeneity.

Author: SciolaLuigi, SpanoAlessandra

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the dynamics of polyploid cell subpopulations in NIHs cells before and after treatment with polyethylene glycol (PEG) and vinblastine. The results demonstrate the role of polyploid cells in tumor evolution and resistance to chemotherapy.
Paper Details　
Original Abstract of the Article :
Neoplastic subpopulations can include polyploid cells that can be involved in tumor evolution and recurrence. Their origin can be traced back to the tumor microenvironment or chemotherapeutic treatment, which can alter cell division or favor cell fusion, generating multinucleated cells. Their progen...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614354/

データ提供：米国国立医学図書館（NLM）

Polyploid Cell Dynamics: A Complex Dance in the Cancer Microenvironment

This research delves into the complex world of polyploid cells, specifically exploring their role in tumor evolution and recurrence. The study investigates the dynamics of polyploid cell populations in a NIH/3T3 derived culture, analyzing their response to treatment with polyethylene glycol (PEG) and the antimicrotubular poison vinblastine. The authors highlight the importance of understanding polyploid cell dynamics in developing effective cancer therapies and preventing tumor recurrence.

Polyploid Cells: A Challenge in Cancer Treatment

This research underscores the complexity of polyploid cells in cancer development and treatment. The study highlights their potential role in tumor evolution and recurrence, emphasizing the need for strategies that target these cells to improve treatment outcomes. This research provides valuable insights into the intricate mechanisms underlying cancer growth and progression.

Navigating Cancer Treatment: A Holistic Approach

Cancer treatment requires a comprehensive understanding of tumor biology and the complex interplay of factors that contribute to tumor growth and spread. This research highlights the importance of considering polyploid cells in cancer treatment, recognizing their potential role in tumor evolution and recurrence. It encourages a holistic approach to cancer therapy, addressing multiple cellular targets to achieve optimal outcomes.

Dr.Camel's Conclusion

This research investigates the dynamics of polyploid cells in a NIH/3T3 derived culture, exploring their response to treatment with polyethylene glycol (PEG) and vinblastine. The authors highlight the importance of understanding polyploid cell dynamics in developing effective cancer therapies and preventing tumor recurrence. This research provides valuable insights into the intricate mechanisms underlying cancer growth and progression.
Date :
  1. Date Completed n.d.
  2. Date Revised 2023-11-02
Further Info :

Pubmed ID

37904245

DOI: Digital Object Identifier

PMC10614354

Related Literature

Article Analysis
・Effects of vinblastine
SNS
PICO Info
in preparation
Languages

English

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