Effects of vinblastine: A Synthesis of Findings from 28 Studies

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Original Abstract of the Article

Main research findings

Vinblastine is a chemotherapy drug used to treat various types of cancer. It is effective in inhibiting the growth of cancer cells by interfering with the formation of microtubules, which are essential for cell division. 20 , 24 , 13 , 8 , 9 , 17 Research has shown that vinblastine also has anti-angiogenic effects, meaning it can prevent the growth of new blood vessels that supply tumors with nutrients and oxygen. 18 , 21 , 8 , 9 Moreover, vinblastine can be used in combination with other chemotherapy drugs to achieve a synergistic effect, meaning the combined effect is greater than the sum of the individual effects. 19 , 9 , 8 , 6

Vinblastine may cause adverse effects such as neutropenia and thrombocytopenia. 23 These side effects can vary depending on the dosage and duration of treatment. It's important to discuss the potential risks and benefits of vinblastine with your doctor before starting treatment.

Benefits and risks

Benefits summary

Vinblastine is an effective chemotherapy drug used to treat various types of cancer. It is effective in inhibiting the growth of cancer cells by interfering with the formation of microtubules, which are essential for cell division. 20 , 24 , 13 , 8 , 9 , 17 Research has shown that vinblastine also has anti-angiogenic effects, meaning it can prevent the growth of new blood vessels that supply tumors with nutrients and oxygen. 18 , 21 , 8 , 9 Moreover, vinblastine can be used in combination with other chemotherapy drugs to achieve a synergistic effect, meaning the combined effect is greater than the sum of the individual effects. 19 , 9 , 8 , 6

Risks summary

Vinblastine may cause adverse effects such as neutropenia and thrombocytopenia. 23 These side effects can vary depending on the dosage and duration of treatment. It's important to discuss the potential risks and benefits of vinblastine with your doctor before starting treatment.

Comparison between studies

Commonalities between studies

Multiple studies have confirmed the effectiveness of vinblastine in inhibiting the growth of cancer cells. 20 , 24 , 13 , 8 , 9 , 17 Studies consistently show that vinblastine can inhibit the growth of new blood vessels that supply tumors with nutrients and oxygen. 18 , 21 , 8 , 9

Differences between studies

Different studies have observed varying levels of side effects from vinblastine treatment, such as neutropenia and thrombocytopenia. 23 These differences could be attributed to factors like animal species, dosage, and duration of treatment.

Consistency and contradictions in results

While research findings generally agree on the effectiveness of vinblastine, there are some inconsistencies observed regarding side effects. For instance, neutropenia and thrombocytopenia have been reported. 23 However, the severity of these side effects varies across studies, potentially influenced by animal species, dosage, and treatment duration.

Points to note for real-world applications

Vinblastine is a chemotherapy drug used to treat cancer. When considering vinblastine treatment, patients should thoroughly discuss the potential risks and benefits with their doctor.

Limitations of current research

The research on vinblastine's effects is still ongoing and requires further investigation. Particularly, more research is needed to understand the specific effects and side effects of vinblastine in humans.

Future research directions

Future research should focus on gaining a deeper understanding of vinblastine's effects and side effects in humans. Additionally, further research into the mechanism of action of vinblastine could lead to the development of more effective chemotherapy drugs.

Conclusion

Vinblastine is a chemotherapy drug that effectively inhibits the growth of cancer cells. However, it can cause side effects like neutropenia and thrombocytopenia. When considering vinblastine treatment, patients should thoroughly discuss the potential risks and benefits with their doctor.

Literature analysis of 28 papers
Positive Content
25
Neutral Content
1
Negative Content
2
Article Type
1
0
0
0
28
3.

Desmoid with biweekly methotrexate and vinblastine shows similar effects to weekly administration: A phase II clinical trial.

Author: NishidaYoshihiro, HamadaShunsuke, UrakawaHiroshi, IkutaKunihiro, SakaiTomohisa, KoikeHiroshi, ItoKan, EmotoRyo, AndoYuichi, MatsuiShigeyuki

DF treatment

This study evaluated the clinical outcomes of a biweekly regimen of low-dose methotrexate plus vinblastine chemotherapy for desmoid-type fibromatosis. The biweekly regimen was well-tolerated and effective, with a clinical benefit rate of 95% and a progression-free survival rate of 80.8% at 5 years.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Effects of Adding Vindoline and MeJA on Production of Vincristine and Vinblastine, and Transcription of their Biosynthetic Genes in the Cultured CMCs of Catharanthus roseus.

Author: ZhangWenjin, YangJiazeng, ZiJiachen, ZhuJianhua, SongLiyan, YuRongmin

Production of vincristine and vinblastine

Catharanthus roseus cambial meristem cells have been shown to produce vincristine and vinblastine when treated with vindoline and methyl jasmonate. This finding suggests a potential for biosynthesis of anticancer drugs in plant cells.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Effects of vinblastine on microvascular anastomosis healing in diabetic rats.

Author: KarşidağSemra, TatlidedeSoner, TosunUğur, YildizKemalettin, KabukçuoğluFevziye, AkçalArzu

Microvascular repair
Chemotherapy
Diabetes mellitus

Preoperative vinblastine had a negative impact on microvascular anastomosis healing in both diabetic and non-diabetic rats, indicating that chemotherapy use can further complicate healing in patients with diabetes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Catharanthine C16 substituent effects on the biomimetic coupling with vindoline: preparation and evaluation of a key series of vinblastine analogues.

Author: TamAnnie, GotohHiroaki, RobertsonWilliam M, BogerDale L

Cytotoxic activity

The presence of an electron-withdrawing substituent at the C16 position of catharanthine is essential for its cytotoxic activity. The C16 methyl ester plays a unique role in this activity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

[Effects of vinblastine nanoparticles on growth and apoptosis of glioma cell line C6].

Author: LiuYumei, OuyangWuqing, ZhangZiqiang, YangXuefeng, MaShuyan

Stronger cytotoxicity to glioma cells

Vinblastine (VLB) nanoparticles (NPS) showed stronger cytotoxicity to glioma cells (C6) compared to VLB physiologic saline solution. The NPS were effective as carriers for VLB delivery into glioma cells, inhibiting cell growth and inducing apoptosis.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Chinese

14.

Xenopus laevis oocytes expressing human P-glycoprotein: probing trans- and cis-inhibitory effects on [3H]vinblastine and [3H]digoxin efflux.

Author: JutabhaPromsuk, WempeMichael F, AnzaiNaohiko, OtomoJun, KadotaToshihito, EndouHitoshi

Drug transport study
Drug-drug interaction study

This study establishes a high-throughput oocyte expression system for studying P-glycoprotein (P-gp)-mediated drug transport, providing a tool for screening compounds and investigating drug-drug interactions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Methanolic extract of Teucrium polium L. potentiates the cytotoxic and apoptotic effects of anticancer drugs of vincristine, vinblastine and doxorubicin against a panel of cancerous cell lines.

Author: RajabalianS

Effective chemosensitizer
Increased apoptosis
Safe
Synergistic effect

A study found that an extract of Teucrium Polium (Me-TP) enhanced the effects of anticancer drugs vinblastine, vincristine, and doxorubicin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

A recombinant peptide, hirudin, potentiates the inhibitory effects of stealthy liposomal vinblastine on the growth and metastasis of melanoma.

Author: GuoRong-Rong, LiuYang, LuWan-Liang, ZhaoJi-Hui, WangXue-Qing, ZhangHua, WangJian-Cheng, ZhangXuan, ZhangQiang

Enhances efficacy
Inhibits metastasis

This study investigated the use of recombinant hirudin and stealthy liposomal vinblastine in inhibiting melanoma cell metastasis. Hirudin inhibited thrombin activity, delayed tumor growth, and reduced metastasis. Combined therapy with hirudin and liposomal vinblastine showed greater anti-metastatic effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Dose effects of continuous vinblastine chemotherapy on mammalian angiogenesis mediated by VEGF-A.

Author: AlbertssonPer, LennernäsBo, NorrbyKlas

Antiangiogenesis effect

Metronomic chemotherapy with vinblastine shows a dose-dependent antiangiogenic effect in a rat mesentery model. A higher dose of vinblastine significantly suppressed angiogenesis, suggesting potential for effective treatment at specific doses.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Combined therapeutic effects of vinblastine and rapamycin on human neuroblastoma growth, apoptosis, and angiogenesis.

Author: MarimpietriDanilo, BrignoleChiara, NicoBeatrice, PastorinoFabio, PezzoloAnnalisa, PiccardiFederica, CilliMichele, Di PaoloDaniela, PagnanGabriella, LongoLuca, PerriPatrizia, RibattiDomenico, PonzoniMirco

Increased lifespan
Inhibited tumor growth

Vinblastine and rapamycin, in combination, have shown to induce a dramatic antiproliferative effect, cell cycle arrest, and apoptosis in neuroblastoma cells, along with a significant inhibition of tumor growth and microvessel area in neuroblastoma-bearing mice.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

22.

Global gene expression analysis of the effects of vinblastine on endothelial cells, when eluted from a thermo-responsive polymer.

Author: McLucasE, GallagherH, RochevY, CarrollW M, GorelovA, SmithT J

In-stent restenosis treatment

Vinblastine, an antimitotic agent, was delivered locally using a thermoresponsive polymer. The drug was found to affect gene expression in human endothelial cells, leading to cell cycle arrest and apoptosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Combination of gamma-radiation antagonizes the cytotoxic effects of vincristine and vinblastine on both mitotic arrest and apoptosis.

Author: SuiMeihua, FanWeimin

This study investigated the potential interactions between vincristine or vinblastine with gamma-radiation against human tumor cells in vitro.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

26.

Effects of vinblastine on healing in microvascular anastomosis.

Author: TatlidedeSoner, KarsidagSemra Hacikerim, TosunUgur, KabukcuogluFevziye, GulMustafa, KuranIsmail

Microsurgical healing
Neutropenia

Preoperative chemotherapy with vinblastine did not significantly affect the healing of microvascular anastomosis in rats. This suggests that preoperative chemotherapy may not negatively impact reconstructive microsurgical procedures in cancer patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

27.

Different effects of vinblastine on the polymerization of isotypically purified tubulins from bovine brain.

Author: KhanIsrar A, LudueñaRichard F

Antitumor drug

This study compared the sensitivity of three tubulin isotypes to vinblastine, a successful antitumor drug. The study found that alpha(beta)II is the most sensitive isotype to vinblastine in the presence of MAPs, while alpha(beta)III is the most resistant.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

28.

The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics.

Author: OkounevaTatiana, HillBridget T, WilsonLeslie, JordanMary Ann

Antitumor activity

Vinflunine, vinorelbine, and vinblastine, three Vinca alkaloids, were tested for their effects on dynamics of centromeres and spindle kinetochore-microtubules. All three drugs suppressed centromere dynamics similarly at concentrations that block mitosis. The strong correlation between suppression of kinetochore-microtubule dynamics and mitotic block indicates that the primary mechanism by which the Vinca alkaloids block mitosis is suppression of spindle microtubule dynamics.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

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