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Nociceptive and Transcriptomic Responses in a Swine Diabetic Wound Model Treated With a Topical AT1R Antagonist.

Author: DavenportMatthew J, DorseySusan G, EnglishEmily, MocciEvelina, RennCynthia L, WeissMiriam N, ZhuShijun

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Treatment-resistant wounds in diabetic patients often cause significant pain. This study explored the potential of targeting the angiotensin 1 receptor (AT1R) with topical treatments to manage pain.
Paper Details　
Original Abstract of the Article :
Painful, treatment-resistant wounds are prevalent among diabetic patients and significantly affect health-related quality of life (HRQOL). Topical treatments may help alleviate pain without risk of dependence or side effects. However, there is a lack of topical wound compounds targeting pain-specifi...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/37916845

データ提供：米国国立医学図書館（NLM）

Treating Diabetic Wounds: A New Path Through Pain

The challenges of [diabetic wounds] are a harsh reality for many individuals. This research explores the potential of [topical AT1R antagonists] as a new approach to managing the pain associated with these wounds. The authors utilized [a swine diabetic wound model] to investigate the effects of a topical AT1R antagonist on [nociceptive] and [transcriptomic] responses. Their findings suggest that targeting the [proinflammatory angiotensin 1 receptor (AT1R)] may be a promising strategy for reducing pain in diabetic wounds.

Navigating the Desert of Pain

The study highlights the significant role of [AT1R] in the pain associated with diabetic wounds. The potential of topical AT1R antagonists to alleviate pain offers a new avenue for managing this challenging condition.

Hope for a Pain-Free Oasis

As Dr. Camel, I find this research incredibly promising. The prospect of a topical treatment that specifically targets pain receptors in diabetic wounds offers hope for a more comfortable and effective management approach.

Dr.Camel's Conclusion

This research explores the potential of targeting the angiotensin 1 receptor (AT1R) to alleviate pain in diabetic wounds. The findings suggest that topical AT1R antagonists may offer a promising new approach to managing this challenging condition. As Dr. Camel, I believe that this research represents a significant step towards a pain-free oasis for individuals with diabetic wounds.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-11-02
Further Info :

Pubmed ID

37916845

DOI: Digital Object Identifier

00006199-990000000-00089

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