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Molecular characterization of rifabutin-resistance in refractory Helicobacter pylori infection in Taiwan.

Author: BuiNgoc-Niem, ChangMing-Ling, ChiuCheng-Hsun, ChiuCheng-Tang, HuangMei-Zi, KeJun-Nong, KuoChia-Jung, LaiChih-Ho, LinCheng-Yu, LinWey-Ran, WuHui-Yu

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the link between rifabutin-resistance in refractory Helicobacter pylori infection and mutations in the rpoB gene. The study found that rifabutin-resistance was associated with specific mutations in rpoB.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: To explore the molecular characteristics of rpoB, encoding β-subunit of DNA-directed RNA polymerase, and unravel the link to rifabutin-resistance in patients with refractory Helicobacter pylori infection. METHODS: From January 2018-March 2021, a total of 1590 patients were screened for ...See full text at original site
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引用元：
https://doi.org/10.1016/j.ijid.2023.11.001

データ提供：米国国立医学図書館（NLM）

Exploring rifabutin-resistance in Helicobacter pylori infection

Helicobacter pylori is a common bacterium that can cause ulcers and other gastrointestinal problems. This study investigates the molecular characteristics of rifabutin-resistance in patients with refractory H. pylori infection. It's like exploring a hidden cave in the desert, searching for the root cause of a persistent problem.

Rifabutin-resistance: A challenge in H. pylori treatment

The researchers studied patients with refractory H. pylori infection, focusing on the gene encoding the β-subunit of DNA-directed RNA polymerase (rpoB). They discovered a correlation between specific mutations in this gene and rifabutin-resistance. It's like finding a hidden map that reveals the secrets of rifabutin-resistance and its impact on the bacterium.

Improving treatment strategies for H. pylori infection

This study provides valuable information for clinicians, helping them better understand the molecular mechanisms underlying rifabutin-resistance and develop more effective treatment strategies for H. pylori infection. It's like finding a new route through the desert, leading to a more successful outcome in the battle against H. pylori.

Dr. Camel's Conclusion

This study offers valuable insights into the molecular basis of rifabutin-resistance in H. pylori infection. By understanding the mechanisms of resistance, we can develop more effective treatments and improve the outcome of patients with this challenging condition.
Date :
  1. Date Completed n.d.
  2. Date Revised 2023-11-30
Further Info :

Pubmed ID

37956898

DOI: Digital Object Identifier

10.1016/j.ijid.2023.11.001

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in preparation
Languages

English

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