Effects of rifabutin: A Synthesis of Findings from 14 Studies

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Original Abstract of the Article

Major Research Findings

Rifabutin is an antibiotic used to treat tuberculosis and mycobacterial infections. Several studies have shown that rifabutin is effective in treating mycobacterial infections when used in combination therapy with other antibiotics. For example, a study found that rifabutin can partially offset P-gp induction by concurrently inhibiting P-gp ( 9 ). Another study found that rifabutin exhibited in vitro activity against macrolide-resistant Mycobacterium abscessus complex clinical isolates ( 7 ). These studies suggest that rifabutin has potential to be effective in treating mycobacterial infections, but further research is needed.

Benefits and Risks

Benefits Summary

Rifabutin is an antibiotic used to treat tuberculosis and mycobacterial infections. Several studies have shown that rifabutin is effective in treating mycobacterial infections when used in combination therapy with other antibiotics. For example, a study found that rifabutin exhibited in vitro activity against macrolide-resistant Mycobacterium abscessus complex clinical isolates ( 7 ). These studies suggest that rifabutin has potential to be effective in treating mycobacterial infections, but further research is needed.

Risks Summary

Rifabutin can cause several side effects, such as liver toxicity, blood disorders, and vision problems. It is important to take rifabutin as directed by your doctor to minimize the risk of these side effects.

Comparison of Studies

Commonalities of Studies

Many studies have shown that rifabutin may be effective in treating mycobacterial infections. However, studies have also shown that rifabutin can cause several side effects, such as liver toxicity, blood disorders, and vision problems. It is important to take rifabutin as directed by your doctor to minimize the risk of these side effects.

Differences in Studies

Rifabutin has been used to treat a variety of mycobacterial infections. These studies suggest that rifabutin may be effective in treating different mycobacterial infections, but further research is needed.

Consistency and Contradictions in Findings

Several studies have shown that rifabutin is effective in treating mycobacterial infections when used in combination therapy with other antibiotics. However, studies have also shown that rifabutin can cause several side effects, such as liver toxicity, blood disorders, and vision problems. It is important to take rifabutin as directed by your doctor to minimize the risk of these side effects.

Considerations for Real-World Applications

Rifabutin is an antibiotic used to treat tuberculosis and mycobacterial infections. Several studies have shown that rifabutin is effective in treating mycobacterial infections when used in combination therapy with other antibiotics. However, studies have also shown that rifabutin can cause several side effects, such as liver toxicity, blood disorders, and vision problems. It is important to take rifabutin as directed by your doctor to minimize the risk of these side effects.

Limitations of Current Research

Research on rifabutin is still limited. Therefore, further research is needed to evaluate the safety and effectiveness of rifabutin.

Future Research Directions

Further research on rifabutin should focus on more detailed evaluations of its safety and effectiveness. Studies are also needed to examine how rifabutin is effective in treating mycobacterial infections when used in combination therapy with other antibiotics.

Conclusion

Rifabutin is an antibiotic used to treat tuberculosis and mycobacterial infections. Several studies have shown that rifabutin is effective in treating mycobacterial infections when used in combination therapy with other antibiotics. However, studies have also shown that rifabutin can cause several side effects, such as liver toxicity, blood disorders, and vision problems. It is important to take rifabutin as directed by your doctor to minimize the risk of these side effects. Further research on rifabutin should focus on more detailed evaluations of its safety and effectiveness. Studies are also needed to examine how rifabutin is effective in treating mycobacterial infections when used in combination therapy with other antibiotics. Rifabutin is considered to be an effective drug for treating several mycobacterial infections. However, rifabutin can cause several side effects, such as liver toxicity, blood disorders, and vision problems. It is important to take rifabutin as directed by your doctor to minimize the risk of these side effects. If you are taking rifabutin, be sure to talk to your doctor and follow their instructions carefully.

Literature analysis of 14 papers
Positive Content
11
Neutral Content
0
Negative Content
3
Article Type
2
0
0
0
11
1.

The effect of multiple doses of ritonavir on the pharmacokinetics of rifabutin.

Author: CatoA, CavanaughJ, ShiH, HsuA, LeonardJ, GrannemanR

Increased rifabutin levels

Ritonavir significantly increases the plasma concentrations of rifabutin and its metabolite 25-O-desacetylrifabutin, suggesting that both drugs are metabolized by CYP3A.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

The effects of rifampin and rifabutin on the pharmacokinetics and pharmacodynamics of a combination oral contraceptive.

Author: Barditch-CrovoP, TrapnellC B, EtteE, ZacurH A, CoreshJ, RoccoL E, HendrixC W, FlexnerC

Drug interactions

Rifampin, a CYP34A inducer, interacts with combination oral contraceptives. This study discusses the need for research on the effects of rifabutin, a related rifamycin, on oral contraceptive efficacy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

6.

Molecular characterization of rifabutin-resistance in refractory Helicobacter pylori infection in Taiwan.

Author: KuoChia-Jung, BuiNgoc-Niem, KeJun-Nong, LinCheng-Yu, LinWey-Ran, ChangMing-Ling, WuHui-Yu, HuangMei-Zi, ChiuCheng-Hsun, ChiuCheng-Tang, LaiChih-Ho

Better treatment
Rifabutin resistance

This study investigated the link between rifabutin-resistance in refractory Helicobacter pylori infection and mutations in the rpoB gene. The study found that rifabutin-resistance was associated with specific mutations in rpoB.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

A Systemic Lupus Erythematosus Patient with Cutaneous <i>Mycobacterium haemophilum</i> Infection under Belimumab Treatment: A Case Report.

Author: KimJonghun, HasegawaToshio, TadaKurisu, UeharaYuki, FukuiYukiko, NakamuraAyako, TakeiSatomi, MitaraiSatoshi, AonoAkio, IkedaShigaku

Effective for SLE
Mycobacterial infection risk

Belimumab is a B cell-targeted biologic drug used to treat systemic lupus erythematosus (SLE). This case report describes a patient who developed Mycobacterium haemophilum infection after starting belimumab therapy. This suggests that belimumab may increase the risk of mycobacterial infections.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

14.

Super acute-onset disseminated BCG infection: A case report.

Author: TakaseRyosuke, HagiyaHideharu, FujimoriTakumi, YokoyamaYukika, IioKoji, HondaHiroyuki, HasegawaKou, OtsukaFumio

Treatment for superficial bladder cancer
Disseminated BCG infection

This case report describes a patient who developed disseminated Bacillus Calmette-Guérin (BCG) infection immediately after receiving the first BCG injection for bladder cancer.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

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