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Repurposing AZD5438 and Dabrafenib for Cisplatin-Induced AKI.

Author: BashirKhalid, HunterWilliam J, IngersollMatthew A, KeirnsDarby L, KresockDaniel F, LutzeRichard D, PushpanChithra K, TeitzTal

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigates whether two anticancer drugs, AZD5438 and dabrafenib, can alleviate cisplatin-induced acute kidney injury (AKI).
Paper Details　
Original Abstract of the Article :
Cisplatin is an effective chemotherapy agent for a wide variety of solid tumors, but its use is dose-limited by serious side effects, including AKI and hearing loss. There are no US Food and Drug Administration-approved drugs to treat both side effects. Recently, two anticancer oral drugs, AZD5438 a...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/37962623

データ提供：米国国立医学図書館（NLM）

Repurposing Drugs for Cisplatin-Induced Toxicity: A New Oasis in Cancer Treatment

The desert of cancer treatment is fraught with challenges, including the side effects of chemotherapy. Cisplatin, a powerful weapon against solid tumors, can also cause kidney damage and hearing loss. This research explores the potential of repurposing two existing anticancer drugs, AZD5438 and dabrafenib, to combat these debilitating side effects, like finding a hidden oasis in the middle of the desert.

A New Strategy for Combating Side Effects

The study proposes that similar pathways are activated in both kidney and inner ear cells when exposed to cisplatin, suggesting that drugs effective against one might also protect the other. It's like discovering that a single camel caravan can be used to navigate both the sandy dunes and the rugged mountains.

Hope for a Better Future

This research offers hope for a more effective and less toxic approach to cancer treatment. If successful, it could alleviate the suffering caused by cisplatin's side effects, allowing patients to better navigate the desert of cancer treatment, making the journey less arduous and more bearable.

Dr.Camel's Conclusion

This research presents an innovative strategy for combating cisplatin-induced toxicity by repurposing existing anticancer drugs. It's a glimmer of hope in the desert of cancer treatment, offering a potential solution to a long-standing challenge. By finding new ways to mitigate side effects, we can create a more compassionate and effective approach to this devastating disease, ensuring a less harsh journey for those battling cancer.
Date :
  1. Date Completed n.d.
  2. Date Revised 2023-12-05
Further Info :

Pubmed ID

37962623

DOI: Digital Object Identifier

00001751-990000000-00214

Related Literature

Article Analysis
・Side Effects of dabrafenib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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