Amantadine withdrawal in a patient with spinocerebellar ataxia.

Author: ChangEmiley, PakAndrew

Paper Details 
Original Abstract of the Article :
We report a case of a man with spinocerebellar ataxia (SCA) on high-dose amantadine who was admitted for acute on chronic dysphagia secondary to progression of SCA. Four days after oral medications were held due to patient's dysphagia, he developed fever, tachycardia and mild rigidity in extremities...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649376/

データ提供:米国国立医学図書館(NLM)

Amantadine Withdrawal Syndrome: A Rare and Unexpected Desert Oasis

Spinocerebellar ataxia (SCA), a neurological disorder affecting balance and coordination, can be as challenging to manage as navigating a desert without a compass. This research, a unique case report, explores a rare phenomenon - amantadine withdrawal syndrome - in a patient with SCA. The authors report the case of a man with SCA who developed a complex constellation of symptoms after discontinuing amantadine, a medication used to manage SCA. It's like encountering a mirage in the desert, a seemingly impossible phenomenon that reveals a deeper truth.

A Rare and Unexpected Phenomenon: Amantadine Withdrawal Syndrome in SCA

The researchers report the case of a man with SCA who experienced fever, tachycardia, rigidity, and encephalopathy after discontinuing amantadine. These symptoms subsided after amantadine was resumed, suggesting that these symptoms were likely due to amantadine withdrawal. This case, like a hidden oasis in the vast desert, offers a valuable lesson about the potential for unexpected side effects when discontinuing medication. It's a reminder that even well-established medications can have unpredictable consequences when withdrawn, highlighting the importance of careful monitoring and individualized management.

Navigating the Complexities of Medication Management: A New Perspective

This case report underscores the importance of carefully considering the potential for medication withdrawal syndromes, even in patients with complex neurological disorders like SCA. This research, like a compass guiding us through the complex landscape of medication management, encourages us to be vigilant and attentive to the potential for unexpected consequences, ensuring the safest and most effective treatment for our patients. It's a reminder that the desert of medicine holds hidden dangers as well as hidden treasures.

Dr.Camel's Conclusion

This case report, like a rare desert flower blooming in the harsh conditions, highlights the importance of careful medication management and the potential for unexpected consequences when discontinuing even seemingly benign medications. It serves as a valuable lesson for clinicians, reminding us to be observant, attentive to detail, and prepared to navigate the complex and sometimes unpredictable world of medicine. It's a reminder that even the most familiar landscapes can hold surprises, and a vigilant approach is essential for ensuring the best possible care for our patients.

Date :
  1. Date Completed 2023-11-16
  2. Date Revised 2023-11-17
Further Info :

Pubmed ID

37963666

DOI: Digital Object Identifier

PMC10649376

Related Literature

SNS
PICO Info
in preparation
Languages

English

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