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Calcium entry blockade or beta-blockade in long-term management of hypertension in blacks.

Author: AmeryA, DituM, FagardR, LepiraB, LijnenP, LissensW, M'Buyamba-KabanguJ R, StaessenJ, TshianiK A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Nitrendipine and acebutolol were effective in controlling hypertension in Black patients. Nitrendipine was slightly more effective than acebutolol in reducing blood pressure, but both medications were safe and well tolerated.
Paper Details　
Original Abstract of the Article :
The long-term efficacy of nitrendipine and acebutolol was assessed during a 40-week double-blind randomized trial in 60 hypertensive blacks. Nitrendipine (mean dose 32 mg/day) and acebutolol (414 mg/day) were administered in monotherapy in increasing dosage and mefruside was added in patients not co...See full text at original site
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引用元：
https://doi.org/10.1038/clpt.1987.7

データ提供：米国国立医学図書館（NLM）

Calcium Entry Blockade vs. Beta-Blockade for Hypertension in Blacks: A Comparative Trial

The field of [cardiology] is constantly seeking to optimize treatment strategies for [hypertension], a prevalent health condition. This study, much like a camel navigating a challenging desert landscape, investigates the long-term efficacy of [nitrendipine], a [calcium entry blocker], and [acebutolol], a [beta-blocker], in managing hypertension in [blacks]. The authors conducted a [double-blind randomized trial] comparing the effectiveness of these two drug classes, providing valuable insights for clinicians managing hypertension in this population.

Calcium Entry Blockade: A Potentially More Effective Option for Hypertension in Blacks

The study's findings, like a desert oasis offering a refreshing respite, suggest that [nitrendipine] may be a more effective option for managing hypertension in [blacks] than [acebutolol]. Nitrendipine resulted in a greater reduction in both [recumbent and standing blood pressures], while [acebutolol] was associated with a significant decrease in [pulse rate]. This discovery, akin to a camel finding a hidden source of water in a dry desert, offers a promising avenue for improving hypertension management in this specific population.

Navigating the Complexities of Hypertension Management: Tailoring Treatment to Individual Needs

This study, much like a desert explorer uncovering hidden treasures, sheds light on the complex interplay between [race] and [hypertension] management. The authors' findings suggest that [calcium entry blockade] may be a more effective approach for managing hypertension in [blacks], highlighting the importance of tailoring treatment strategies to individual patient characteristics.

Dr. Camel's Conclusion

This study, much like a camel navigating a challenging desert landscape, investigates the long-term efficacy of nitrendipine, a calcium entry blocker, and acebutolol, a beta-blocker, in managing hypertension in blacks. The authors conducted a double-blind randomized trial comparing the effectiveness of these two drug classes, providing valuable insights for clinicians managing hypertension in this population.

Date :
  1. Date Completed 1987-03-02
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

3802705

DOI: Digital Object Identifier

10.1038/clpt.1987.7

Related Literature

Article Analysis
・Side Effects of acebutolol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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