Intervention effects of fructooligosaccharide and astragalus polysaccharide, as typical antibiotic alternatives, on antibiotic resistance genes in feces of layer breeding: advantages and defects.

Antibiotic Alternatives and Antibiotic Resistance Genes in Poultry

The poultry industry is constantly seeking alternatives to antibiotics in order to prevent the development of antibiotic resistance, a growing concern in animal agriculture. This study investigates the effects of two common antibiotic alternatives, fructooligosaccharide (FOS) and astragalus polysaccharide (APS), on antibiotic resistance genes (ARGs) found in the feces of laying hens. The researchers used metagenomic sequencing and fluorescence quantitative PCR to analyze the impact of these alternatives on the abundance of ARGs in the gut microbiome.

The findings demonstrate that while FOS effectively reduced the total abundance of ARGs, it did not completely eliminate all types of resistance genes. FOS was particularly effective at increasing the abundance of Lactobacillus, a beneficial bacteria, while reducing the abundance of Escherichia, a bacteria often associated with higher ARG levels. However, certain types of ARGs, such as those conferring resistance to aminoglycosides and tetracyclines, were not significantly reduced by FOS. This suggests that FOS may have limitations in controlling the spread of specific antibiotic resistance genes.

Addressing the Challenges of Antibiotic Alternatives

The study highlights the need for a multifaceted approach to managing antibiotic resistance in livestock and poultry production. While antibiotic alternatives can play a role in reducing overall ARG levels, they may not completely eliminate all types of resistance genes. This reinforces the importance of implementing comprehensive strategies to address this issue, such as optimizing animal husbandry practices, improving biosecurity measures, and promoting the use of more sustainable and effective antibiotic alternatives.

The Importance of Gut Microbiome Research

This research underlines the complex relationship between the gut microbiome, antibiotic resistance, and animal health. Understanding the dynamics of these factors is crucial for developing effective strategies to manage antibiotic resistance and ensure the health and safety of both animals and humans.

Dr. Camel's Conclusion

While FOS shows promise as an antibiotic alternative in poultry production, it's important to recognize its limitations in controlling the spread of specific antibiotic resistance genes. Further research is needed to develop more comprehensive strategies to combat antibiotic resistance in animal agriculture, ensuring the long-term sustainability of food production and the health of both animals and humans.