Paper Details

  1. Home
  2. Paper Details

Intranasal administration of sertraline ensures sustained brain delivery and antidepressant effect in a mouse model of depression.

Author: BickerJoana, FalcãoAmílcar, FonsecaCarla, FortunaAna, SilvaSoraia

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Intranasal (IN) administration of sertraline was investigated for its potential as an antidepressant therapy. IN sertraline exhibited heightened systemic exposure and sustained brain delivery, suggesting its potential for improved efficacy and reduced side effects compared to oral administration.
Paper Details　
Original Abstract of the Article :
The pursuit of more potent and efficacious antidepressant therapies is of utmost significance. Herein, intranasal (IN) route was investigated for sertraline brain delivery, encompassing a comparative pharmacokinetic study after a single-dose administration to mice by IN, intravenous (IV) (4.87 mg/kg...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.ejpb.2023.12.002

データ提供：米国国立医学図書館（NLM）

Sertraline Delivered Through the Nose: A Novel Approach to Depression Treatment

This research explores a novel method for delivering the antidepressant sertraline directly to the brain through the nasal passage, much like a camel navigating a shortcut through a narrow canyon to reach a hidden oasis. The researchers found that intranasal administration of sertraline resulted in sustained brain delivery and an antidepressant effect in a mouse model of depression. This suggests a promising new avenue for treating depression, potentially offering a more targeted and effective approach.

Navigating the Desert of Depression

The study offers a potential breakthrough in the treatment of depression, a challenging condition that can feel like a vast and unforgiving desert.

The Potential of Intranasal Drug Delivery

The study’s findings suggest that intranasal drug delivery could be a promising strategy for treating depression, offering a potentially more effective and convenient approach. It’s like discovering a new route to a hidden oasis, providing a faster and more efficient pathway to a desired destination.

Dr. Camel's Conclusion

This research provides valuable insights into the potential of intranasal drug delivery for treating depression. The study’s findings offer a promising new avenue for developing more effective and targeted treatments. It’s a testament to the creativity and ingenuity of scientists in seeking innovative solutions to challenging health problems.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-12-13
Further Info :

Pubmed ID

38092320

DOI: Digital Object Identifier

10.1016/j.ejpb.2023.12.002

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.