Side Effects of sertraline: A Synthesis of Findings from 8 Studies

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Original Abstract of the Article

Major research findings

Sertraline is a commonly prescribed selective serotonin reuptake inhibitor (SSRI) used to treat conditions like depression, anxiety, and PTSD. Several studies have explored the side effects associated with sertraline. These studies have identified various side effects, including gastrointestinal issues, sexual dysfunction, and fatigue. Furthermore, potential interactions between sertraline and other medications have been noted. For example, a study documented in 3 found that patients receiving both sertraline and phototherapy exhibited side effects such as diarrhea, hyperthermia, nausea, and confusion. The authors believe these symptoms were likely due to an interaction between the two treatments, specifically, a potentiation of serotonin's effects. Additionally, a study published in 2 showed that sertraline was associated with a higher occurrence of gastrointestinal problems compared to citalopram. Conversely, a study described in 7 demonstrated that intranasal administration of sertraline in mice significantly increased the drug's delivery to the brain, thereby enhancing its antidepressant effects. Moreover, a case series report presented in 8 found that sertraline was safe and effective in treating depression among hemodialysis patients.

Reasons for side effects

Sertraline achieves its therapeutic effects by increasing serotonin levels within the brain. Serotonin, a neurotransmitter, plays a crucial role in regulating mood, sleep, appetite, and sexual function. By boosting serotonin levels, sertraline can potentially influence these functions, which may contribute to the observed side effects.

Common side effects

Gastrointestinal problems

Gastrointestinal problems are frequently reported as a side effect of sertraline. For instance, a study detailed in 2 highlighted that a significant number of patients taking sertraline experienced gastrointestinal issues. These problems can include nausea, vomiting, diarrhea, constipation, and abdominal pain.

Sexual dysfunction

Sertraline has been associated with sexual dysfunction. A study documented in 2 revealed that many patients taking sertraline reported experiencing sexual dysfunction. These issues can encompass decreased sexual desire, erectile dysfunction, and difficulty ejaculating.

Fatigue

Fatigue is another common side effect of sertraline. For example, a study outlined in 2 indicated that many patients taking sertraline experienced fatigue.

Other side effects

Beyond gastrointestinal problems, sexual dysfunction, and fatigue, sertraline can potentially trigger various other side effects. These side effects may include headache, dizziness, drowsiness, anxiety, tremors, weight gain, and sweating.

Countermeasures for side effects

Gastrointestinal problems

If you experience gastrointestinal problems while taking sertraline, it is advisable to consult your doctor. Your doctor may recommend medication to alleviate your symptoms or provide dietary guidance.

Sexual dysfunction

If you experience sexual dysfunction while taking sertraline, it is essential to consult your doctor. Your doctor may prescribe medication to mitigate your symptoms or explore alternative treatment options.

Fatigue

If you feel fatigued while taking sertraline, it is recommended that you prioritize adequate sleep and engage in light exercise. If your fatigue persists, consult your doctor.

Comparison between studies

Commonalities in studies

Across numerous studies, common side effects associated with sertraline include gastrointestinal problems, sexual dysfunction, and fatigue.

Differences between studies

Variations exist in the frequency and severity of side effects associated with sertraline among different studies. These discrepancies can be attributed to differences in study participants and methodology.

Notes on application to real life

Sertraline is an effective medication for treating mental illnesses such as depression, anxiety disorders, and PTSD. However, it is crucial to consult your doctor before taking sertraline due to its potential side effects. Your doctor will tailor the dosage and method of administering sertraline based on your individual symptoms and medical condition.

Limitations of current research

The research on side effects associated with sertraline is still considered incomplete. Further research is warranted to gain a more comprehensive understanding of the frequency, severity, and underlying causes of these side effects.

Directions for future research

Further research into the side effects of sertraline is essential. This research should prioritize efforts to elucidate the underlying causes of these side effects and develop effective treatments to mitigate their impact.

Conclusion

Sertraline is a valuable medication for treating mental illnesses such as depression, anxiety disorders, and PTSD, but it can potentially induce side effects such as gastrointestinal problems, sexual dysfunction, and fatigue. It is important to consult your doctor before taking sertraline and to seek medical attention if you experience any side effects. More research is needed to understand the side effects of sertraline more thoroughly.

Literature analysis of 8 papers
Positive Content
6
Neutral Content
1
Negative Content
1
Article Type
2
0
0
0
8
2.

Can physiologic assessment and side effects tease out differences in PTSD trials? A double-blind comparison of citalopram, sertraline, and placebo.

Author: TuckerPhebe, Potter-KimballRobin, WyattDorothy B, ParkerDon E, BurginChristie, JonesDan E, MastersBarbara K

Improved PTSD symptoms
Lower blood pressure
Appetite changes
Fatigue
GI problems
Insomnia
Sexual dysfunction

This study investigated the effects of two selective serotonin reuptake inhibitors (SSRIs), citalopram and sertraline, compared to placebo on chronic posttraumatic stress disorder (PTSD). All three treatment groups improved significantly in PTSD symptoms and sleep time. However, there were subtle differences in improvements in PTSD symptom clusters, physiologic reactivity, and reported adverse events.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Side effects after phototherapy implementation in addition to fluoxetine or sertraline treatment: a report of two cases.

Author: SwiecickiŁukasz, SzafrańskiTomasz

Serotonergic side effects

Patients receiving fluoxetine or sertraline experienced serotonergic side effects after phototherapy. This is the first report of such an interaction, suggesting that phototherapy should be discontinued in patients taking these medications.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Antidepressant side effects in depression patients treated in a naturalistic setting: a study of bupropion, moclobemide, paroxetine, sertraline, and venlafaxine.

Author: VanderkooyJ D, KennedySidney H, BagbyR Michael

Depression treatment
Central nervous system side effects
Gastrointestinal side effects
Sexual side effects

The TSES was a simple, clinician-administered antidepressant side-effect scale. Paroxetine differed from the other antidepressants on a measure of sexual dysfunction.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Comparison of sertraline to fluoxetine with regard to their efficacy and side effects in the treatment of premature ejaculation.

Author: Murat BaşarM, AtanA, YildizM, BaykamM, AydogănliL

Premature ejaculation treatment
Mild side effects

Fluoxetine and sertraline have the same efficacy and side effects in the treatment of premature ejaculation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Comparative sexual side effects of bupropion, fluoxetine, paroxetine, and sertraline.

Author: ModellJ G, KatholiC R, ModellJ D, DePalmaR L

Improved sexual function
Increased libido
Decreased sexual function

SSRI-induced adverse sexual effects appear to be the rule rather than the exception and may be substantially underreported. In contrast, prosexual effects were reported by the majority of patients treated with bupropion.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Use of sertraline and agomelatine in hemodialysis patients: A case series report.

Author: KubanekAlicja, PrzybylakMateusz, PaulPrzemysław, KowalskaAnna Sylwia, BłaszczykMichał, Macul-SanewskaAleksandra, RenkeMarcin, RutkowskiPrzemysław, BidzanLeszek, GrabowskiJakub

MDD treatment
Hemodialysis complications

This study investigates the safety and effectiveness of sertraline and agomelatine in treating major depressive disorder (MDD) in hemodialysis patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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