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[Pharmacokinetics of aztreonam in peripheral venous serum, uterine arterial serum and intrapelvic female organs].

Author: KawanoK, MiyakawaI, MoriN, NagaiK, SendaiM V, TaniyamaK, YamaoH

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Aztreonam (AZT) achieved therapeutic concentrations in the uterus and adnexal tissues. The study found that AZT reached effective levels in female genital organs, suggesting its potential for treating infections in the female urogenital tract.
Paper Details　
Original Abstract of the Article :
The concentrations of aztreonam (SQ 26,776, AZT, Squibb) in peripheral venous serum, uterine arterial serum and intrapelvic female organs were determined by bioassay, using the cylinder-plate diffusion method, in 27 women with simple total hysterectomy. With an intravenous injection of AZT 1 g, the ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/3834156

データ提供：米国国立医学図書館（NLM）

Aztreonam: A Potential Treatment for Female Urogenital Tract Infections

The treatment of infections in the female urogenital tract is a significant challenge for healthcare providers. This study investigates the pharmacokinetics of aztreonam, a potent antibiotic, in the female reproductive system. Researchers conducted a study involving 27 women undergoing simple total hysterectomy, analyzing the concentrations of aztreonam in peripheral venous serum, uterine arterial serum, and intrapelvic female organs.

Aztreonam: Effective Penetration into Female Genital Organs

The study revealed that aztreonam effectively penetrated into the female genital organs, reaching therapeutic concentrations in both uterine arterial serum and intrapelvic organs. The concentration in uterine arterial serum was significantly higher than the minimal inhibitory concentration required for most Gram-negative bacteria for at least 8 hours after injection. Furthermore, the concentrations of aztreonam in the female genital organs remained higher than the minimal inhibitory concentration against E. coli for at least 4 hours after injection.

Navigating the Labyrinth of Infections

Imagine a labyrinth with many twists and turns, representing the complex anatomy of the female reproductive system. Aztreonam, like a skilled explorer, effectively navigates through these intricate pathways, reaching its target and effectively combating infection.

Dr. Camel's Conclusion

This study provides compelling evidence for the potential of intravenous aztreonam as an effective treatment option for infections of the female urogenital tract. The study highlights the importance of understanding drug pharmacokinetics and achieving therapeutic concentrations in target tissues for optimal treatment outcomes.

Date :
  1. Date Completed 1986-05-23
  2. Date Revised 2016-11-16
Further Info :

Pubmed ID

3834156

DOI: Digital Object Identifier

3834156

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Languages

Japanese

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