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Adjuvant chemo- and hormonal therapy in locally advanced breast cancer: a randomized clinical study.

Author: EngelsmanE, HartG, Schaake-KoningC, van der LindenE H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of 118 patients with locally advanced breast cancer found that adjuvant chemotherapy and hormonal therapy did not improve overall survival.
Paper Details　
Original Abstract of the Article :
Between 1977 and 1980, 118 breast cancer patients with locally advanced disease, T3B-4, any N, M0 or T1-3, tumor positive axillary apex biopsy, were randomized to one of three arms: I: radiotherapy (RT) to the breast and adjacent lymph node areas; II: RT followed by 12 cycles of cyclophosphamide, me...See full text at original site
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引用元：
https://doi.org/10.1016/0360-3016(85)90028-8

データ提供：米国国立医学図書館（NLM）

Adjuvant Therapy in Locally Advanced Breast Cancer: A Randomized Trial

Breast cancer is a complex and challenging disease, and the search for effective treatments is a continuous journey. This study investigates the role of adjuvant chemo- and hormonal therapy in patients with locally advanced breast cancer. The researchers conducted a randomized clinical trial to compare the effectiveness of three different treatment regimens, including radiotherapy (RT) alone, RT followed by chemotherapy and tamoxifen, and a more intensive chemotherapy regimen with tamoxifen.

Adjuvant Therapy: Limited Impact on Overall Survival

The study found that the addition of adjuvant chemo- and hormonal therapy did not significantly improve overall survival in patients with locally advanced breast cancer. The researchers observed similar survival rates across all three treatment arms, suggesting that RT alone might be sufficient for some patients with this type of breast cancer.

Personalized Treatment for Breast Cancer: A Multifaceted Approach

This research highlights the need for a personalized approach to breast cancer treatment, considering the individual patient's characteristics and disease stage. It's like navigating a complex desert landscape, where the optimal route depends on the specific terrain and resources available. The findings suggest that a multidisciplinary approach, involving careful evaluation of treatment options and considering factors like tumor characteristics and patient preferences, is crucial for achieving optimal outcomes.

Dr.Camel's Conclusion

This study is a reminder that the battle against breast cancer is a multifaceted journey. It emphasizes the importance of individualized treatment plans, considering the specific needs of each patient and the complexity of the disease. The findings encourage a collaborative approach between healthcare professionals and patients to navigate the challenges of breast cancer and achieve the best possible outcomes.

Date :
  1. Date Completed 1985-10-29
  2. Date Revised 2019-07-08
Further Info :

Pubmed ID

3840149

DOI: Digital Object Identifier

10.1016/0360-3016(85)90028-8

Related Literature

Article Analysis
・Effective treatment of breast cancer
SNS
PICO Info
in preparation
Languages

English

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