Treatment of childhood renal osteodystrophy with calcitriol or ergocalciferol.

Author: DunstanC R, EvansR A, HillsE, HodsonE M, RosenbergA R, RoyL P, WongS Y

Paper Details 
Original Abstract of the Article :
Quantitative bone histology, biochemistry and height velocities were studied in 18 children suffering from chronic renal failure. Eight received calcitriol, 7 ergocalciferol and 3, though alloted to a treatment group, failed to comply with therapy. A histochemical stain for aluminum showed heavy dep...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/3877585

データ提供:米国国立医学図書館(NLM)

Tackling Bone Trouble in Youngsters with Kidney Issues

This research dives deep into the world of childhood renal osteodystrophy, a condition where bone health takes a hit due to chronic kidney failure. The study delved into the effectiveness of two vitamin D treatments, calcitriol and ergocalciferol, in restoring bone health in 18 young patients. The researchers meticulously examined bone structure, blood chemistry, and growth rates over time. They found that both treatments significantly improved bone health in most patients, with minimal side effects for ergocalciferol. This discovery could pave the way for better treatment options for children facing this challenging condition.

A Clear Winner in Bone Restoration

Ergocalciferol emerged as the leading contender in this study due to its similar effectiveness with fewer side effects compared to calcitriol. The study showed that both treatments led to noticeable improvements in bone health, as evidenced by positive changes in bone structure, reduced levels of parathyroid hormone, and increased calcium levels in the blood. Ergocalciferol, however, yielded less frequent instances of hypercalcemia. These findings suggest that ergocalciferol might be the preferred choice for treating renal bone disease in children.

Keeping Bones Strong: A Parent's Guide

The good news is that this study suggests that there are effective treatment options available for children with renal osteodystrophy. However, maintaining good bone health is crucial for children with this condition, as strong bones help them grow and lead active lives. Parents should prioritize regular checkups and ensure their children follow their prescribed treatments diligently. A healthy diet rich in calcium and vitamin D, along with regular exercise, can also contribute to strong and healthy bones.

Dr.Camel's Conclusion

This study sheds light on the effectiveness of vitamin D treatments in children with renal osteodystrophy. While both calcitriol and ergocalciferol showed positive results, ergocalciferol emerged as the preferred choice due to its fewer side effects. It's a reminder that even in the vast desert of medical challenges, there are oases of hope and effective treatments waiting to be discovered.

Date :
  1. Date Completed 1986-01-22
  2. Date Revised 2016-11-23
Further Info :

Pubmed ID

3877585

DOI: Digital Object Identifier

3877585

Related Literature

SNS
PICO Info
in preparation
Languages

English

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