Side Effects of ergocalciferol: A Synthesis of Findings from 10 Studies

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Original Abstract of the Article

Main research findings

Ergocalciferol, a type of vitamin D, has been shown in several studies to be effective in treating renal osteodystrophy in patients with chronic kidney disease (CKD). 8 . Ergocalciferol improves bone tissue, increases serum calcium levels, and reduces parathyroid hormone and alkaline phosphatase levels. 8 . Ergocalciferol is also effective in treating vitamin D deficiency in pregnant Asian women, improving vitamin D levels in both mothers and fetuses, and reducing the risk of hypocalcemia. 10 . In addition, ergocalciferol has been shown to be effective in preventing fractures in the elderly. 6 . However, ergocalciferol can have side effects if taken in high doses. .

Reasons for side effects

Side effects of ergocalciferol occur due to vitamin D overdose. Vitamin D promotes calcium absorption. Therefore, taking too much vitamin D can lead to excessive calcium accumulation in the body, potentially causing side effects such as hypercalcemia.

Common side effects

Hypercalcemia

Hypercalcemia can occur if you take too much ergocalciferol. 8 . Hypercalcemia can cause symptoms such as loss of appetite, nausea, vomiting, constipation, dehydration, muscle pain, and mental confusion. 8 . In addition, hypercalcemia can increase the risk of kidney stones and cardiovascular disease.

Soft tissue calcification

Ergocalciferol overdose can lead to calcium deposition in soft tissues. 7 . Soft tissue calcification can affect tissues such as blood vessels, heart, and kidneys.

Countermeasures for side effects

Countermeasures for hypercalcemia

If you experience symptoms of hypercalcemia, stop taking ergocalciferol and follow your doctor's instructions. 8 . Treatment for hypercalcemia includes hydration, diuretics, and medications such as calcitonin.

Countermeasures for soft tissue calcification

To prevent soft tissue calcification, it is important to avoid taking ergocalciferol more than the recommended amount. 7 . It is also necessary to pay attention to your calcium intake.

Comparison between studies

Common points in studies

Multiple studies have shown that ergocalciferol improves bone tissue, increases serum calcium levels, and reduces parathyroid hormone and alkaline phosphatase levels. 8 10 . In addition, ergocalciferol can have side effects such as hypercalcemia when taken in high doses. .

Differences in studies

Comparative studies of ergocalciferol and calcitriol have shown that calcitriol has a higher risk of hypercalcemia. 8 . Ergocalciferol has also been shown to be effective in preventing fractures in the elderly. 6 . On the other hand, calcitriol has been shown to be effective in treating vitamin D deficiency in pregnant Asian women. 10 .

Precautions for application in real life

Ergocalciferol can be helpful in treating vitamin D deficiency and preventing fractures. 6 . However, taking too much ergocalciferol can increase the risk of side effects such as hypercalcemia. . Therefore, it is important to follow your doctor's instructions when taking ergocalciferol.

Current research limitations

Research on the side effects of ergocalciferol is not yet sufficient. Further research, particularly on long-term side effects, is needed.

Future research directions

Further research is needed to clarify the long-term side effects of ergocalciferol. It is also important to develop methods to reduce the side effects of ergocalciferol.

Conclusion

Ergocalciferol is an effective type of vitamin D that can help treat vitamin D deficiency and prevent fractures. 6 . However, taking high doses can increase the risk of side effects such as hypercalcemia. . Therefore, it is important to follow your doctor's instructions when taking ergocalciferol.

Literature analysis of 10 papers
Positive Content
9
Neutral Content
1
Negative Content
0
Article Type
3
0
0
2
10
1.

Vitamin D and Diabetic Retinopathy.

Author: Gverović AntunicaAntonela, ZnaorLjubo, IvankovićMira, PuzovićVelibor, MarkovićIrena, KaštelanSnježana

Bone health
Diabetic retinopathy treatment
Immune system health
Side effects
Sunburn

Diabetic retinopathy (DR) is a common complication of diabetes, and vitamin D deficiency is a risk factor. This article reviews the role of vitamin D in DR, highlighting its potential benefits and risks associated with supplementation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

2.

A double-blind, randomized, placebo-controlled trial of combined calcitriol and ergocalciferol versus ergocalciferol alone in chronic kidney disease with proteinuria.

Author: SusantitaphongPaweena, NakwanSiriwan, PeerapornratanaSadudee, TiranathanagulKhajohn, KatavetinPisut, SrisawatNattachai, PraditpornsilpaKearkiat, Eiam-OngSomchai

CKD treatment
Vitamin D supplementation

This study explores the effect of adding active vitamin D to nutritional vitamin D supplementation in CKD patients with vitamin D insufficiency/deficiency. The findings suggest that adding active vitamin D may have a beneficial effect on proteinuria and kidney function in these patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Vitamin D metabolites and/or analogs: which D for which patient?

Author: MazzaferroS, GoldsmithD, LarssonT E, MassyZ A, CozzolinoM

Corrected vitamin D deficiency
Improved bone disease
Suppressed parathyroid activity
Hypercalcemia

This paper reviews the characteristics and potential clinical indications of various vitamin D drugs, focusing on renal patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Ergocalciferol treatment and aspects of mineral homeostasis in patients with chronic kidney disease stage 4-5.

Author: GravesenEva, Hofman-BangJacob, LewinEwa, OlgaardKlaus

CKD treatment
FGF23 elevation

This study examined the effects of high doses of ergocalciferol on parameters of mineral homeostasis in predialysis CKD patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Treatment of childhood renal osteodystrophy with calcitriol or ergocalciferol.

Author: HodsonE M, EvansR A, DunstanC R, HillsE, WongS Y, RosenbergA R, RoyL P

Renal Bone Disease Treatment
Hypercalcemia

Both ergocalciferol and calcitriol improve bone histology in children with chronic renal failure, but calcitriol has more side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Prevention of osteonecrosis following renal transplantation by using vitamin D2 (ergocalciferol).

Author: ScholzD, MebelM, TöpelmannI, GrossmannI, ScholzeJ, MrochenH

Lower osteonecrosis incidence
Minimal side effects
Hypercalcemia

Vitamin D2 was effective in reducing osteonecrosis after renal transplantation, with minimal side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Vitamin D supplements in pregnant Asian women: effects on calcium status and fetal growth.

Author: BrookeO G, BrownI R, BoneC D, CarterN D, CleeveH J, MaxwellJ D, RobinsonV P, WinderS M

Adequate vitamin D levels
Improved maternal weight gain
No side effects

Vitamin D supplements are effective in preventing hypocalcemia in pregnant Asian women. They also improve bone ossification in infants.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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