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Effect of omeprazole and cimetidine on duodenal ulcer. A double-blind comparative trial.

Author: AndersenH H, BendtsenF, BytzerP, HøjlundM, JensenK G, KelbaekH, LauritsenK, LindeJ, Rask-MadsenJ, RuneS J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Omeprazole accelerates healing and pain relief in patients with duodenal ulcer, compared to cimetidine. However, long-term toxicity studies have shown the development of gastric carcinoid tumors in rats.
Paper Details　
Original Abstract of the Article :
We conducted a double-blind randomized study of 132 patients to determine whether the new, investigational proton-pump inhibitor, omeprazole (30 mg per day), would accelerate healing and pain relief, as compared with cimetidine (1 g per day), in patients with duodenal ulcer. After two weeks of treat...See full text at original site
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引用元：
https://doi.org/10.1056/NEJM198504113121505

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 1985-04-24
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

3883182

DOI: Digital Object Identifier

10.1056/NEJM198504113121505

Related Literature

Article Analysis
・Effects of omeprazole
SNS
PICO Info
in preparation
Languages

English

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