Effects of omeprazole: A Synthesis of Findings from 36 Studies

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Original Abstract of the Article

Major Findings

Omeprazole is a proton pump inhibitor that effectively suppresses gastric acid secretion. 23 , 13 , 32 , 36 , 8 , 20 , 33 , 21 , 1 , 11 , 27 , 7 , 25 , 10 , , 30 , 18 , 17 , 16 , 28 , 19 , 35 , 9 , 34 , 15 , 29 , 26 , 5 , 2 , 14 , 22 , , 31 , 6 , 12 , 4 Omeprazole has been shown to be effective in treating duodenal ulcers, promoting healing and reducing pain. 10 , 5 It is also used to treat Helicobacter pylori infection, leading to eradication of the bacteria. 20 , 25 , 27 , 14 , 31 Omeprazole is effective in treating gastroesophageal reflux disease. 32 , 29 Research has shown that omeprazole has comparable or superior acid suppression effects compared to other proton pump inhibitors. 31 , 30 Moreover, omeprazole provides long-lasting acid suppression effects. 13 , 1 , 33 Omeprazole may affect gastric motility. 6 Omeprazole increases gastric pH, making the stomach more alkaline by suppressing acid secretion. 11 Omeprazole can affect the absorption of other drugs. 23 , 25 , 18 , 22 Omeprazole can be administered orally or intravenously. 11 , 26 The dosage of omeprazole varies depending on the symptoms and disease. 12 , 5 Omeprazole has the potential to cause side effects. 10 , 14 Side effects are generally mild and often resolve upon discontinuation. 10 Long-term use of omeprazole has been linked to an increased risk of gastric carcinoid tumors. 10

Benefits and Risks

Benefits Summary

Omeprazole effectively suppresses gastric acid secretion, making it a valuable treatment for duodenal ulcers, gastroesophageal reflux disease, and Helicobacter pylori infection. Omeprazole has comparable or superior acid suppression effects compared to other proton pump inhibitors, and provides long-lasting acid suppression. It can be administered orally or intravenously, and the dosage is adjusted based on the individual's symptoms and disease.

Risks Summary

Omeprazole can cause side effects, although these are typically mild and tend to resolve upon stopping the medication. However, long-term use has been associated with an increased risk of gastric carcinoid tumors. It is important to understand these risks before using omeprazole.

Comparison Across Studies

Similarities Across Studies

Numerous studies have demonstrated that omeprazole effectively suppresses gastric acid secretion. The consistent findings across studies show that omeprazole is an effective treatment for duodenal ulcers, gastroesophageal reflux disease, and Helicobacter pylori infection.

Differences Across Studies

The dosage and administration method of omeprazole vary across different studies. The results on the effectiveness and side effects of omeprazole also differ across research. For example, some studies have shown a potential impact of omeprazole on gastric motility while others haven't found such an impact. Similarly, some studies indicate that omeprazole might affect the absorption of other medications, while others do not. While long-term use of omeprazole has been linked to a risk of gastric carcinoid tumors, not all studies have confirmed this association.

Consistency and Discrepancies in Findings

The effectiveness of omeprazole in suppressing gastric acid secretion is consistently demonstrated across multiple studies. However, there is variation in findings related to the potential side effects of omeprazole, particularly concerning long-term use. Further research is needed to fully understand the long-term effects of omeprazole.

Practical Considerations

While omeprazole effectively suppresses gastric acid secretion, it also carries potential risks. Understanding these risks and following the doctor's instructions for dosage and administration is crucial when using this medication. Regular consultations with a healthcare professional are important to monitor for potential side effects, particularly for individuals on long-term omeprazole treatment.

Limitations of Current Research

Some studies on omeprazole lack comprehensive assessments of the long-term side effects of its use. Additional research is required to better understand the impact of omeprazole on gastric motility, absorption of other drugs, and potential drug interactions.

Future Research Directions

Further research is essential to thoroughly investigate the long-term side effects associated with omeprazole use, its impact on gastric motility and drug absorption, and the potential interactions with other medications. A deeper understanding of these aspects is crucial for ensuring the safe and effective use of omeprazole.

Conclusion

Omeprazole is a valuable medication for effectively suppressing gastric acid secretion, making it a suitable treatment for duodenal ulcers, gastroesophageal reflux disease, and Helicobacter pylori infection. However, it's important to be aware of the potential risks associated with omeprazole, including side effects and the possibility of long-term complications. Consult your doctor before using omeprazole, and follow their instructions regarding dosage and administration. Continued research on omeprazole is important to better understand its long-term effects and potential interactions with other medications.

Literature analysis of 36 papers
Positive Content
34
Neutral Content
2
Negative Content
0
Article Type
35
1
0
0
36
1.

Omeprazole (20 mg) daily given in the morning or evening: a comparison of effects on gastric acidity, and plasma gastrin and omeprazole concentration.

Author: ChivertonS G, HowdenC W, BurgetD W, HuntR H

Reduced gastric acidity
Variable response

Omeprazole is more effective when administered in the morning compared to the evening in duodenal ulcer patients. While morning administration resulted in a significant increase in mean pH, evening administration did not show a significant difference from placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Repeated intravenous bolus injections of omeprazole: effects on 24-hour intragastric pH, serum gastrin, and serum pepsinogen A and C.

Author: BaakL C, BiemondI, JansenJ B, LamersC B

Increased gastric pH

Intravenous omeprazole significantly increased 24-h intragastric pH, but failed to continuously raise pH levels above 4.0 in 8 out of 10 subjects. A cumulative effect was observed after repeated boluses, but marked interindividual variation in response was also noted.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Omeprazole 20 mg three days a week and 10 mg daily in prevention of duodenal ulcer relapse. Double-blind comparative trial.

Author: LauritsenK, AndersenB N, LaursenL S, HansenJ, HavelundT, EriksenJ, RehfeldJ F, KjaergaardJ, Rask-MadsenJ

Prevent ulcer relapse
No major side effects

Both omeprazole regimens (20 mg 3 days a week and 10 mg daily) were effective and safe in preventing duodenal ulcer relapse.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Omeprazole versus placebo in duodenal ulcer healing. The United States experience.

Author: GrahamD Y, McCulloughA, SklarM, SontagS J, RoufailW M, StoneR C, BishopR H, GitlinN, CagliolaA J, BermanR S

Pain relief
Ulcer healing
Gastrin elevation

Omeprazole is a proton pump inhibitor used to treat duodenal ulcers. This study compared the ulcer healing effects and safety of omeprazole and placebo. Omeprazole significantly improved healing rates and pain relief compared to placebo. Omeprazole was well tolerated with few adverse events.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Effect of 10 mg and 20 mg omeprazole daily on duodenal ulcer: double-blind comparative trial.

Author: LauritsenK, AndersenB N, HavelundT, LaursenL S, HansenJ, EriksenJ, JørgensenT, Rask-MadsenJ

Heals duodenal ulcers
Relieves pain
None reported

Omeprazole 20 mg daily was more effective than 10 mg daily in healing duodenal ulcers in 155 patients. Both doses were well-tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

The effects of omeprazole on gastro-oesophageal sphincter pressure, intragastric pH, and the migrating motor complex in fasting healthy subjects.

Author: PedersenS A, KraglundK, Vinter-JensenL

Effective for oesophagitis
Reduced acid secretion

Omeprazole (80 mg) was found to be as effective as placebo in treating patients with oesophagitis, with no differences in the pressure profile of the lower oesophageal sphincter.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Low dose omeprazole effects on gastric acid secretion in normal man.

Author: HemeryP, GalmicheJ P, RozeC, IsalJ P, Bruley des VarannesS, LavignolleA, Le BodicL

Inhibit gastric acidity
Increase serum gastrin

This study evaluated the effects of a low dose of omeprazole (10mg) on stomach acid production. It found that it reduced acid levels significantly and for a long time without significantly affecting gastrin levels.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

The effects of omeprazole on endocrine function in man.

Author: MacGilchristA J, HowdenC W, KenyonC J, BeastallG H, ReidJ L

No endocrine effects

Omeprazole, a drug used to reduce stomach acid, did not affect various endocrine functions in healthy volunteers, suggesting it is unlikely to cause significant interference with hormone levels.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Effects of low dose omeprazole on gastric secretion and plasma gastrin in patients with healed duodenal ulcer.

Author: HowdenC W, DerodraJ K, BurgetD W, HuntR H

Gastric acid reduction

Low doses of omeprazole showed limited effectiveness in reducing gastric acid secretion. The study found that low doses of omeprazole did not consistently decrease gastric acidity and required higher doses for significant effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Effect of omeprazole and cimetidine on duodenal ulcer. A double-blind comparative trial.

Author: LauritsenK, RuneS J, BytzerP, KelbaekH, JensenK G, Rask-MadsenJ, BendtsenF, LindeJ, HøjlundM, AndersenH H

Duodenal Ulcer Healing
Pain Relief
Gastric Carcinoid Tumors

Omeprazole accelerates healing and pain relief in patients with duodenal ulcer, compared to cimetidine. However, long-term toxicity studies have shown the development of gastric carcinoid tumors in rats.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Intravenous omeprazole rapidly raises intragastric pH.

Author: WaltR P, ReynoldsJ R, LangmanM J, SmartH L, KitchingmanG, SomervilleK W, HawkeyC J

Increased gastric pH
Reduced acidity
High IV dose

Intravenous omeprazole effectively reduced intragastric acidity in patients with duodenal ulcers, maintaining a gastric pH above 4.0 for most of the time.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Omeprazole in duodenal ulceration: acid inhibition, symptom relief, endoscopic healing, and recurrence. Cooperative study.

Author:

Duodenal ulceration treatment
Nausea

Omeprazole was effective in healing duodenal ulceration. The ulcer healed in 41 of 43 patients who completed the treatment. Most patients were symptom-free after one week. Side effects were generally mild and resolved spontaneously.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Omeprazole inhibition of nocturnal gastric secretion in patients with duodenal ulcer.

Author: HetzelD J, ShearmanD J

Reduces acid output
None reported

Omeprazole, a proton pump inhibitor, significantly reduced overnight gastric acid output in 7 male subjects with duodenal ulcers, with the effect lasting throughout the study period.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Limited efficacy of omeprazole-based dual and triple therapy for Helicobacter pylori: a randomized trial employing "optimal" dosing.

Author: LaineL, SteinC, NeilG

H. pylori eradication
Side effects

Dual therapy with omeprazole and amoxicillin had limited efficacy in eradicating Helicobacter pylori infection, with an eradication rate of 50%. Adding tetracycline did not improve the eradication rate. The study suggests that differences in H. pylori strains or host factors may explain the lower eradication rates observed in the study population, which consisted primarily of Hispanic individuals.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Effects of omeprazole and lansoprazole on 24-hour intragastric pH in Helicobacter pylori-positive volunteers.

Author: VerdúE F, FraserR, ArmstrongD, BlumA L

Lansoprazole antisecretory efficacy
Omeprazole antisecretory efficacy

Omeprazole and lansoprazole were comparably effective antisecretory agents in H. pylori-positive subjects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Antisecretory effects of three omeprazole regimens for maintenance treatment in duodenal ulcer.

Author: SavarinoV, MelaG S, ZentilinP, CutelaP, MeleM R, PerilliD, VassalloA, ZambottiA, MansiC, CelleG

Reduced gastric acidity

This study compared three different omeprazole regimens for maintenance treatment of duodenal ulcers. All three regimens were effective in reducing gastric acidity, with omeprazole 20 mg every other day being the most effective.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Antisecretory effect of three premeal doses of cimetidine 400 mg versus a single morning dose of omeprazole 20 mg: pathophysiological implications for duodenal ulcer treatment.

Author: SavarinoV, MelaG S, ZentilinP, CutelaP, MansiC, VassalloA, FranceschiM, MelaM R, DallortoE, CelleG

Duodenal Ulcer Healing

Omeprazole and cimetidine are both drugs used to reduce stomach acid. A study of 15 patients with duodenal ulcers found that omeprazole was more effective than cimetidine in increasing gastric pH.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Pharmacokinetic and pharmacodynamic interactions between omeprazole and amoxycillin in Helicobacter pylori-positive healthy subjects.

Author: PommerienW, BraunM, IdströmJ P, WrangstadhM, LondongW

Helicobacter pylori treatment

Omeprazole is used to treat Helicobacter pylori infection, and it was hypothesized that omeprazole-induced hypoacidity might enhance the antibacterial activity of amoxycillin. This study investigated intragastric pH and amoxycillin bioavailability during combination therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

The effects of omeprazole 20 and 40 mg twice daily on intragastric acidity in duodenal ulcer patients.

Author: SavarinoV, MelaG S, ZentilinP, MeleM R, VigneriS, MansiC, CelleG

Helicobacter pylori treatment

The combination of omeprazole with amoxycillin or clarithromycin is used to treat Helicobacter pylori infection. This combination is likely to be more effective when omeprazole is taken twice daily, as this helps to raise gastric pH.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

An increasing dose of omeprazole combined with amoxycillin cures Helicobacter pylori infection more effectively.

Author: MiehlkeS, MannesG A, LehnN, HeleC, StolteM, BayerdörfferE

Effective H. pylori treatment

This study aims to determine how the dosage of omeprazole influences the cure rate of H. pylori infection and investigates other factors affecting treatment success.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

Twenty-four-hour intragastric acidity and plasma gastrin during 3-month treatment with omeprazole in healthy subjects.

Author: DelchierJ C, BenamouzigR, StanescuL, RopertA, VallotT, WirquinV, RoudotF, LamarqueD, HamelinB

Long-term acid suppression
Increased gastrin response

Omeprazole 20 and 40 mg/day provided long-term stable acid suppression with a progressive increase in gastrin response, stabilizing after 2 months of treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Acid suppression by omeprazole does not affect orally administered metronidazole bioavailability and metabolism in healthy male volunteers.

Author: DavidF L, Da SilvaC M, MendesF D, FerrazJ G, MuscaraM N, MorenoH, De NucciG, PedrazzoliJ

No effect on metronidazole pharmacokinetics

This study found that a 5-day administration of omeprazole does not affect the pharmacokinetic parameters of orally administered metronidazole in healthy volunteers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Transfer of metronidazole to gastric juice: impact of Helicobacter pylori infection and omeprazole.

Author: CalafattiS A, dos SantosA, da SilvaC M, DeguerM, CarvalhoA F, MendesF D, FerrazJ G, BentoA P, PereiraA A, PiovesanaH, de NucciG, LernerF, PedrazzoliJ

Omeprazole, a proton pump inhibitor, was found to have no significant effect on the transfer of metronidazole from plasma to the gastric juice in individuals with and without H. pylori infection.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Eradication of Helicobacter pylori compared with long-term acid suppression in duodenal ulcer disease. A randomized trial with 2-year follow-up. The Danish Ulcer Study Group.

Author: BytzerP, AalykkeC, RuneS, WeywadtL, GjørupT, EriksenJ, BonnevieO, BekkerC, Kromann-AndersenH, KjaergaardJ, Rask-MadsenJ, VilienM, HansenJ, JustesenT, VybergM, TeglbjaergP S

Treats duodenal ulcer

This study compared the symptomatic effects of eradication therapy with those of long-term omeprazole treatment in patients with duodenal ulcer disease. The study aimed to evaluate effects on dyspeptic and reflux symptoms, not just ulcer recurrence.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Transfer of clarithromycin to gastric juice is enhanced by omeprazole in Helicobacter pylori-infected individuals.

Author: PedrazzoliJ, CalafattiS A, OrtizR A, DiasF E, DeguerM, MendesF D, BentoA P, PereiraA A, PiovesanaH, FerrazJ G, LernerF, de NucciG

H. pylori eradication
Drug distribution impact

This study investigated the effects of omeprazole on clarithromycin distribution in the gastric juice of individuals with Helicobacter pylori infection. Omeprazole is a proton pump inhibitor used to treat H. pylori infection. The study aimed to understand how proton pump inhibitors affect the distribution of drugs used for H. pylori eradication.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

The comparative effects of single intravenous doses of omeprazole and famotidine on intragastric pH.

Author: AbeYasunobu, InamoriMasahiko, TogawaJun-Ichi, KikuchiTaisuke, MuramatsuKenichi, ChiguchiGaku, KawamuraHarunobu, KobayashiNoritoshi, KirikoshiHiroyuki, SakaguchiTakashi, TakamuraTomoo, NakajimaAtsushi, UenoNorio, SekiharaHisahiko

Hemostasis promotion
Rapid action
Symptom relief

This study investigates the inhibitory effects of omeprazole and famotidine on gastric acid secretion after single intravenous administrations.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Long-term effects of eradication of Helicobacter pylori on relapse and histology in gastric ulcer patients: a two-year follow-up study.

Author: BefritsR, SjöstedtS, TourR, LeijonmarckC-E, HedenborgL, BackmanM,

Gastric ulcer prevention

Helicobacter pylori eradication effectively prevents gastric ulcer relapse, even in patients taking non-steroidal anti-inflammatory drugs (NSAIDs).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

Comparison of the effects of immediate-release omeprazole powder for oral suspension and pantoprazole delayed-release tablets on nocturnal acid breakthrough in patients with symptomatic gastro-oesophageal reflux disease.

Author: CastellD, BaginR, GoldlustB, MajorJ, HepburnB

Nocturnal acidity control

Many patients with gastro-oesophageal reflux disease continue to experience nocturnal gastric acidity even with proton-pump inhibitor treatment. A previous study suggested that a bedtime dose of immediate-release omeprazole may be more effective than delayed-release proton-pump inhibitors.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

Rabeprazole is equivalent to omeprazole in the treatment of erosive gastro-oesophageal reflux disease. A randomised, double-blind, comparative study of rabeprazole and omeprazole 20 mg in acute treatment of reflux oesophagitis, followed by a maintenance open-label, low-dose therapy with rabeprazole.

Author: PaceF, AnneseV, PradaA, ZambelliA, CasaliniS, NardiniP, Bianchi PorroG,

Healing reflux oesophagitis
Heartburn relief

Rabeprazole is equivalent to omeprazole in healing reflux oesophagitis, but shows a faster activity on reflux symptoms in the early treatment phase.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

30.

Acid-suppressive effects of generic omeprazole: comparison of three brands of generic omeprazole with original omeprazole.

Author: ShimataniT, InoueM, KuroiwaT, XuJ, MienoH, TazumaS

Acid suppression
Generic variation

The acid-suppressive effects of some brands of generic omeprazole are not the same as original omeprazole. These differences may be reflected in clinical outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

31.

A meta-analysis: comparison of esomeprazole and other proton pump inhibitors in eradicating Helicobacter pylori.

Author: WangXia, FangJing-Yuan, LuRong, SunDan-Feng

Effective H. pylori eradication
Well tolerated

Esomeprazole-based triple therapy is effective in eradicating Helicobacter pylori infection and is comparable in efficacy to omeprazole-based therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

32.

Which has superior acid-suppressive effect, 10 mg omeprazole once daily or 20 mg famotidine twice daily? Effects of single or repeated administration in Japanese Helicobacter pylori-negative CYP2C19 extensive metabolizers.

Author: ShimataniTomohiko, InoueMasaki, KuroiwaTomoko, MoriwakiMutsuko, XuJing, IkawaKazuro, MorikawaNorifumi, TazumaSusumu

GERD maintenance
Heartburn relief
Drug interactions
Tolerance phenomenon

Low-dose omeprazole is superior to full-dose famotidine for maintenance therapy for gastroesophageal reflux disease, whereas 'on-demand' famotidine is more effective for relief of heartburn episodes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

33.

Acid-suppressive effects of various regimens of omeprazole in Helicobacter pylori-negative CYP2C19 homozygous extensive metabolizers: which regimen has the strongest effect?

Author: ShimataniTomohiko, KuroiwaTomoko, MoriwakiMutsuko, XuJing, TazumaSusumu, InoueMasaki

Acid suppression

This study compared the effects of different omeprazole regimens on intragastric pH in healthy subjects. Omeprazole 20 mg bid was found to have the strongest effect, particularly in nighttime acid suppression.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

34.

Pharmacokinetic profile of immediate-release omeprazole in patients with gastro-oesophageal reflux associated with gastroparesis.

Author: WoJ M, EversmannJ, MannS

GERD treatment

Immediate-release omeprazole was associated with a more rapid absorption and less variable pharmacokinetic profile compared with delayed-release omeprazole in patients with gastroparesis.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

35.

Early effects of oral administration of esomeprazole and omeprazole on the intragastric pH.

Author: IidaHiroshi, InamoriMasahiko, OkunoKotone, SekinoYusuke, SakaiEiji, OkuboHidenori, HigurashiTakuma, EndoHiroki, HosonoKunihiro, YonedaMasato, KoideTomoko, TakahashiHirokazu, GotoAyumu, KubotaKensuke, SaitoSatoru, MaedaShin, NakajimaAtsushi, GotohEiji

Increased intragastric pH

Single oral administration of esomeprazole 20 mg increased the intragastric pH more rapidly than single oral administration of omeprazole 20 mg in Helicobacter pylori-negative healthy male subjects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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