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Effects of combination cholestyramine-neomycin treatment on plasma lipoprotein concentrations in type II hyperlipoproteinemia.
Author: BaileyK R, BrewerH B, GreggR E, HoegJ M, MaherM B, SprecherD L, ZechL A
Original Abstract of the Article :
Recent prospective clinical trials have established that cholesterol reduction in patients with elevated (upper 90th percentile) concentrations of low-density lipoproteins (LDL) reduces the incidence of myocardial infarction and sudden death. Because the level of protection from these cardiovascular...See full text at original site
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引用元:
https://doi.org/10.1016/0002-9149(85)90489-8
データ提供:米国国立医学図書館(NLM)
Combination Therapy for Type II Hyperlipoproteinemia: A Tale of Limited Synergy
The realm of [hyperlipoproteinemia] is a desert where imbalances in blood lipids lead to a heightened risk of cardiovascular disease. This research investigates the effectiveness of a combination therapy using cholestyramine and neomycin, two drugs commonly used to lower cholesterol levels in patients with type II hyperlipoproteinemia. The study aims to determine whether combining these drugs leads to a greater reduction in cholesterol levels compared to using them individually.
The study, like a desert explorer seeking a more efficient route through a vast and arid landscape, finds that while cholestyramine effectively reduces cholesterol levels, the addition of neomycin does not provide an additive benefit. Instead, neomycin actually reduces high-density lipoprotein (HDL) cholesterol, which is like discovering a promising oasis only to find it's a mirage.
Navigating Lipid Management
The study's findings highlight the importance of carefully considering the impact of different drug combinations on various lipid fractions. It's like a desert traveler choosing the right path based on the type of terrain and the resources available. This personalized approach to lipid management is crucial to ensure that treatment strategies effectively address the specific needs of each patient.
Cholesterol Management: A Complex Journey
This research, like a desert explorer's log detailing the intricate details of a challenging journey, underscores the complexity of lipid management. It's a reminder that finding effective treatment strategies requires a thorough understanding of the different factors at play, including the specific lipid fractions and the potential interactions between different medications.
Dr.Camel's Conclusion
The desert of lipid management is vast and multifaceted. This research, like a desert explorer's journal, reveals the complex interplay of various factors influencing the effectiveness of cholesterol-lowering therapies. It's a reminder that the quest for effective treatment strategies requires a comprehensive understanding of the terrain and the intricate relationships between different interventions.
Date :
- Date Completed 1985-06-03
- Date Revised 2019-06-22
Further Info :
Related Literature
English
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