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Efficacy of penbutolol and a combination of a low dose of penbutolol with piretanide in the treatment of mild to moderate hypertension.

Author: EnglertR, GramlE, HäringerE, PahnkeK, RangoonwalaB, VerhoM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

In 51 patients with mild to moderate hypertension, the combination of penbutolol (20 mg) plus piretanide (3 mg) and penbutolol (40 mg) alone effectively reduced blood pressure. Diastolic blood pressure normalized in 70% of patients receiving the combination and 59% receiving penbutolol alone. No significant side effects were reported.
Paper Details　
Original Abstract of the Article :
A double-blind study was carried out in two parallel groups of patients with mild to moderate hypertension to assess the efficacy and tolerance of the combination 20 mg penbutolol plus 3 mg piretanide in comparison to 40 mg penbutolol alone over a period of 6 weeks. Active drug treatment in the 51 p...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/3903788

データ提供：米国国立医学図書館（NLM）

Efficacy of Penbutolol and a Combination of a Low Dose of Penbutolol with Piretanide in the Treatment of Mild to Moderate Hypertension

This study delves into the [cardiology] field and investigates the efficacy of two different treatment regimens for mild to moderate hypertension: penbutolol alone and a combination of penbutolol and piretanide. The study employs a [double-blind, placebo-controlled trial] to compare the effectiveness and tolerability of these two treatment approaches in patients with mild to moderate hypertension. The research reveals that both treatment regimens effectively reduced systolic and diastolic blood pressure, with a slightly higher normalization rate observed in the combination group. The study concludes that both penbutolol alone and the combination of penbutolol and piretanide are effective and well-tolerated treatments for mild to moderate hypertension.

Effective Treatment Options for Hypertension

This research provides valuable insights into the management of mild to moderate hypertension. The study's findings suggest that both penbutolol alone and a combination of penbutolol and piretanide are effective treatment options for this common condition.

Managing Hypertension: A Multifaceted Approach

This research underscores the importance of individualized treatment approaches for hypertension. The study's findings highlight the need to carefully consider the patient's individual needs and preferences, as well as potential risks and benefits of different treatment options.

Dr.Camel's Conclusion

Hypertension is a silent but dangerous force in the desert of healthcare. This research offers valuable insights into two effective treatments for this condition. It's like having two different oases in the desert, each providing a safe haven for those struggling with hypertension. The study emphasizes the importance of choosing the right treatment option based on the patient's individual needs and preferences.
Date :
  1. Date Completed 1985-12-18
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

3903788

DOI: Digital Object Identifier

3903788

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Article Analysis
・Side Effects of penbutolol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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