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Recurrent genital herpes suppressed by oral acyclovir: a multicentre double blind trial.

Author: AyraO P, FiddianA P, JeffriesD J, RodinP, TaylorP K, ThinR N, YeoJ

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of 88 patients with frequent genital herpes found that taking acyclovir (200 mg four times daily) for 84 days significantly reduced the number of outbreaks compared to placebo. Only 13% of patients on acyclovir developed lesions, compared to 88% on placebo. The drug was well-tolerated, and while the time to recurrence after treatment ended was similar for both groups, the study suggests that continuous acyclovir therapy may be helpful for preventing outbreaks during specific times, such as during exams or vacations.
Paper Details　
Original Abstract of the Article :
Eighty-eight of 111 patients with frequently recurring genital herpes attending five centres completed a randomized, double-blind, cross over trial with 200 mg oral acyclovir four times daily for 84 days before or after a similar course of placebo tablets. During the course of placebo 77 (88%) patie...See full text at original site
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引用元：
https://doi.org/10.1093/jac/16.2.219

データ提供：米国国立医学図書館（NLM）

Managing Recurrent Genital Herpes: Acyclovir Offers Suppression

Genital herpes is a common and often recurring viral infection that can significantly impact a person's quality of life. This study explores the effectiveness of oral acyclovir in suppressing recurrent genital herpes. The researchers conducted a randomized, double-blind, crossover trial to compare the efficacy of acyclovir to placebo in preventing herpes outbreaks. Their findings highlight the potential of acyclovir as a treatment option for frequently recurring genital herpes.

Acyclovir: A Potential Solution for Frequent Herpes Outbreaks

The researchers discovered that continuous oral acyclovir therapy significantly reduced the frequency of herpes outbreaks compared to placebo. They observed a substantial reduction in the number of patients experiencing lesions, symptoms, or signs of recurrence. These findings suggest that acyclovir may be a valuable tool for managing frequent herpes outbreaks, providing relief from the symptoms and improving quality of life. It's like discovering a hidden spring in a barren desert, offering a much-needed source of hydration and relief.

Harnessing the Power of Acyclovir for Herpes Management

This research provides valuable insights into the potential of acyclovir for managing recurrent genital herpes. While further research is needed to fully understand its optimal use and long-term effects, the findings suggest that it may be a promising option for individuals experiencing frequent outbreaks. It's a reminder that even in the seemingly endless desert of viral infections, we can find effective treatments to alleviate symptoms and improve quality of life. Just as a skilled desert navigator finds ways to navigate challenging terrain, we continue to explore new avenues for managing viral infections.

Dr.Camel's Conclusion

This research offers hope for those struggling with recurrent genital herpes. Acyclovir has shown promise in suppressing outbreaks, offering a potential oasis of relief in the challenging desert of this viral infection. It's a testament to the ongoing advancements in antiviral therapy, constantly seeking new solutions to improve patient well-being.

Date :
  1. Date Completed 1986-01-06
  2. Date Revised 2019-05-11
Further Info :

Pubmed ID

3905750

DOI: Digital Object Identifier

10.1093/jac/16.2.219

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Article Analysis
・Effective treatment of genital herpes
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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