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[Bacteriological, pharmacokinetic and clinical studies on aztreonam in the pediatric field. Pediatric Study Group of Aztreonam].

Author: ArimasuO, FuyiiR, IshizukaY, MatsumotoK, MeguroH, NakazawaS, NaritaA, SatoH, SunakawaK, SuzukiH

English AbstractA summary of a research paper/publication written in English for a wider audience.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Aztreonam, a new monobactam antibiotic, is effective in treating various infections in pediatric patients, particularly those caused by Gram-negative bacteria. The drug is well tolerated and has a high rate of bacterial elimination.
Paper Details　
Original Abstract of the Article :
This report summarizes the results of joint studies in pediatrics on aztreonam, the first monobactam antibiotic for practical use. Pharmacokinetics was studied in 53 cases administered with 10, 20, 40 and 50 mg/kg of aztreonam (AZT) by intravenous injection and 20 cases with 10, 20, 30, and 40 mg/kg...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/3912524

データ提供：米国国立医学図書館（NLM）

Aztreonam: A New Hope for Pediatric Infections

[Antibiotic resistance] is a growing concern, especially in the field of [pediatrics]. This study examined the [pharmacokinetic and clinical efficacy] of [aztreonam], a [monobactam antibiotic], in the treatment of [infections] in children. The researchers conducted a series of studies involving a total of [291 pediatric patients] and investigated the antibiotic's [pharmacokinetic properties] and [clinical effectiveness] in different types of infections.

Effective Against Gram-Negative Bacteria

The results showed that [aztreonam] demonstrated [high efficacy] against [Gram-negative bacteria] such as [E. coli, H. influenzae, P. aeruginosa]. The study also found that [aztreonam] had good [cerebrospinal fluid penetration], making it a potential option for treating [meningitis].

Combatting Infection with Knowledge

Just as a camel navigates a desert by relying on its keen sense of direction, understanding the [pharmacokinetics] and [efficacy] of antibiotics is crucial for treating infections. This research highlights the importance of [continued research and development] in [antibiotic therapy], especially in the context of [pediatric care].

Dr. Camel's Conclusion

This study provides valuable insights into the effectiveness of aztreonam in treating infections in children. The drug's efficacy against Gram-negative bacteria and its ability to penetrate the cerebrospinal fluid make it a potentially valuable tool for treating a range of infections in this vulnerable population.

Date :
  1. Date Completed 1986-04-21
  2. Date Revised 2016-11-16
Further Info :

Pubmed ID

3912524

DOI: Digital Object Identifier

3912524

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・Effects of aztreonam injection
SNS
PICO Info
in preparation
Languages

Japanese

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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