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Which drug for the adult epileptic patient: phenytoin or valproate?

Author: ChadwickD W, HowelD, RawlinsM D, TurnbullD M

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A study of 140 patients with tonic-clonic or partial seizures found no significant difference in effectiveness between sodium valproate and phenytoin in achieving a two-year remission or preventing seizures. However, patients with a history of partial seizures had a significantly lower rate of achieving two-year remission compared to those with only tonic-clonic seizures. The study concluded that both medications are equally effective in treating epilepsy, regardless of seizure type, but individual patient characteristics, like seizure history, can impact treatment success.
Paper Details　
Original Abstract of the Article :
A series of 140 previously untreated patients with tonic-clonic or partial seizures were randomised to receive either phenytoin or sodium valproate. There was no difference between the treatment groups in pretreatment variables that might influence outcome. Sodium valproate and phenytoin in the trea...See full text at original site
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引用元：
https://doi.org/10.1136/bmj.290.6471.815

データ提供：米国国立医学図書館（NLM）

Choosing the Right Path: Phenytoin vs. Valproate for Epilepsy

Epilepsy, a neurological disorder characterized by seizures, can be a challenging condition to manage. Imagine epilepsy as a shifting desert landscape, unpredictable and prone to sudden changes. This study investigates the effectiveness of two common antiepileptic drugs, phenytoin and valproate, in controlling seizures. The researchers conducted a randomized controlled trial involving 140 patients with epilepsy, comparing the two medications. The results showed no significant difference in efficacy between phenytoin and valproate in achieving two-year remission from seizures. However, the study highlighted the importance of considering individual factors, such as the type of seizure, when choosing a treatment option.

Navigating the Epilepsy Landscape

This study provides valuable insights for managing epilepsy. The findings suggest that both phenytoin and valproate can be effective treatment options, but the choice may depend on individual characteristics and the type of seizure experienced.

Finding the Right Treatment for Epilepsy

If you are living with epilepsy, it's crucial to work closely with a healthcare professional to determine the best treatment plan for your individual needs. The choice of medication should be based on your medical history, seizure type, and other factors.

Dr.Camel's Conclusion

This study is like a compass, guiding us through the complex world of epilepsy treatment. While there is no one-size-fits-all approach, the research provides valuable information to help patients and their healthcare providers navigate this challenging journey.

Date :
  1. Date Completed 1985-05-10
  2. Date Revised 2019-05-01
Further Info :

Pubmed ID

3919805

DOI: Digital Object Identifier

10.1136/bmj.290.6471.815

Related Literature

Article Analysis
・Effective treatment of seizures
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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