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Role of débridement and trifluridine (trifluorothymidine) in herpes simplex dendritic keratitis.

Author: CohenE J, DreizenN G, GalentineP G, LaibsonP R, ParlatoC J, SakauyeC M

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A study of 34 patients with herpes simplex dendritic keratitis compared three treatments: debridement alone, trifluridine alone, and debridement plus trifluridine. Debridement alone had a higher failure rate compared to the other two treatments. Trifluridine alone and debridement plus trifluridine showed similar healing times. These findings suggest that debridement alone is not an effective treatment for this condition, and that combining debridement with trifluridine does not provide additional benefit compared to trifluridine alone.
Paper Details　
Original Abstract of the Article :
Thirty-four patients with herpes simplex dendritic keratitis were randomized into three treatment categories: Group A had débridement alone; group B, trifluridine (trifluorothymidine) alone; and group C, débridement and trifluridine. Patients treated with débridement alone had a statistically higher...See full text at original site
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引用元：
https://doi.org/10.1001/archopht.1985.01050050065019

データ提供：米国国立医学図書館（NLM）

Treating Herpes Simplex Dendritic Keratitis: Débridement vs. Trifluridine

This study investigated the effectiveness of different treatment approaches for herpes simplex dendritic keratitis, a viral infection of the cornea. It's like a fierce desert sandstorm attacking a fragile oasis, and the researchers are trying to find the best way to protect it. The study compared the effectiveness of débridement (removing infected tissue) alone, trifluridine (an antiviral drug) alone, and a combination of both. The results indicated that débridement alone was not an effective treatment, while trifluridine alone and the combination were equally effective in healing the infection. This is like realizing that simply sweeping away the sand from an oasis won't stop a sandstorm, but applying a protective barrier will.

The Power of Antiviral Medications: A Study of Effective Treatments

This study highlights the importance of antiviral medications in treating herpes simplex dendritic keratitis. Trifluridine emerged as a promising treatment option, providing effective results in the majority of cases. This is like finding a source of water in the desert, a vital resource for healing and recovery.

Protecting Your Eyes: A Reminder to Seek Medical Advice

This study emphasizes the importance of seeking medical attention for any eye infection, as early diagnosis and appropriate treatment are essential for preventing potential complications. This is like being guided by a skilled traveler through the vast and challenging desert landscape, ensuring safe and efficient navigation.

Dr. Camel's Conclusion

This research underscores the crucial role of antiviral medications in treating herpes simplex dendritic keratitis. While débridement alone proved ineffective, trifluridine emerged as a valuable tool in the fight against this eye infection. It's like finding a rare desert plant that holds the key to healing and protection.

Date :
  1. Date Completed 1985-06-06
  2. Date Revised 2019-07-04
Further Info :

Pubmed ID

3922338

DOI: Digital Object Identifier

10.1001/archopht.1985.01050050065019

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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