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Improvement in exercise performance with nisoldipine, a new second-generation calcium blocker, in stable angina patients.
Author: HollandJ P, LopezL M, MehtaJ L, RubinM R
Original Abstract of the Article :
Safety and efficacy of a new dihydropyridine calcium antagonist, nisoldipine, were studied in 15 patients with proved coronary artery disease and positive exercise treadmill tests. After withdrawal of current therapy and a 2-week placebo phase, patients were given nisoldipine 10, 20, and 40 mg daily...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/0002-8703(85)90198-x
データ提供:米国国立医学図書館(NLM)
Nisoldipine: A Second-Generation Calcium Blocker for Angina Relief
The field of cardiovascular medicine constantly seeks better ways to manage angina, a condition characterized by chest pain caused by reduced blood flow to the heart. This study evaluated the safety and efficacy of a new calcium blocker called nisoldipine in patients with stable angina. The study design was structured to compare the effects of different doses of nisoldipine to a placebo. The researchers measured various parameters, such as exercise tolerance, time to angina onset, and heart rate, during exercise treadmill tests. The results showed that nisoldipine significantly improved exercise performance in all patients, with higher doses leading to greater improvements. Nisoldipine also reduced angina frequency and nitroglycerin consumption, offering a welcome relief for patients struggling with these symptoms. The side effects were minimal, making nisoldipine a promising therapeutic option for angina management.
Nisoldipine: A Heart-Healthy Solution
The study's findings suggest that nisoldipine effectively improves exercise tolerance and reduces angina symptoms in stable angina patients. This is a significant development in the management of angina, a condition that can significantly impact quality of life. The fact that nisoldipine can be taken twice daily instead of multiple times like other calcium blockers adds to its appeal for many patients.
Easing Angina: A Step Towards a More Active Life
Nisoldipine provides hope for individuals living with stable angina. The ability to exercise more comfortably and reduce angina episodes can significantly improve a patient’s overall well-being. It’s important to remember that while this study demonstrates the potential benefits of nisoldipine, it’s essential to consult a doctor for proper diagnosis and personalized treatment plans. Just like a camel needs to be guided through the vast desert, a heart needs a knowledgeable guide to navigate the complexities of cardiovascular health.
Dr. Camel's Conclusion
Nisoldipine offers a promising new approach for managing stable angina. The drug's ability to improve exercise tolerance, reduce angina episodes, and offer a convenient dosing schedule makes it a valuable addition to the cardiovascular physician's arsenal. As with any medication, it's crucial to discuss your individual needs and treatment options with a healthcare professional.
Date :
- Date Completed 1985-12-04
- Date Revised 2019-06-26
Further Info :
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