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Cardiovascular effects of ophthalmic timolol.

Author: BakerN D, LeierC V, WeberP A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Ophthalmic timolol maleate, a beta-adrenergic blocker used to treat glaucoma, was found to reduce resting and exercise heart rate, as well as oxygen consumption at maximal exercise. Despite these cardiovascular effects, plasma levels of timolol were often undetectable and never exceeded 2.8 ng/mL.
Paper Details　
Original Abstract of the Article :
We studied cardiovascular effects related to ophthalmic timolol maleate, a beta-adrenergic blocker commonly used to treat chronic glaucoma. Twenty normal subjects were randomly assigned to two double-blind treatment groups each with ten subjects. One group received two drops of ophthalmic timolol (0...See full text at original site
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引用元：
https://doi.org/10.7326/0003-4819-104-2-197

データ提供：米国国立医学図書館（NLM）

Cardiovascular Effects of Ophthalmic Timolol: Exploring the Desert of Drug Interactions

This study examines the cardiovascular effects of ophthalmic timolol maleate, a beta-adrenergic blocker commonly used to treat chronic glaucoma. It's like a camel caravan trekking through the desert of drug interactions, seeking to understand the potential consequences of using timolol for eye conditions. The researchers conducted a double-blind study, randomly assigning 20 subjects to receive either ophthalmic timolol or a placebo. They found that ophthalmic timolol significantly decreased resting and maximal exercise heart rate, reduced oxygen consumption at maximal exercise, and blunted the augmentation in exercise capacity seen during placebo therapy.

Navigating the Desert of Drug Interactions: Understanding Timolol's Cardiovascular Effects

The study highlights the potential cardiovascular effects of ophthalmic timolol, even though the plasma levels of the drug were often undetectable. It underscores the importance of considering potential drug interactions and monitoring cardiovascular health in patients using ophthalmic timolol.

A Desert of Drug Effects: The Importance of Informed Decision-Making

This study serves as a reminder that medications, even those intended for specific conditions, can have broader effects on the body. It emphasizes the need for informed decision-making, considering both the intended benefits and potential side effects of medications.

Dr. Camel's Conclusion

This study underscores the importance of understanding the potential side effects of medications, even those used for seemingly localized conditions. It's a reminder that the desert of drug effects can be vast and complex, and we must navigate it with caution and informed decision-making.
Date :
  1. Date Completed 1986-02-28
  2. Date Revised 2019-06-19
Further Info :

Pubmed ID

3946944

DOI: Digital Object Identifier

10.7326/0003-4819-104-2-197

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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