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The effects of combined morphine and prochlorperazine on ventilatory control in humans.

Author: HensleyM J, OlsonL G, SaundersN A

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Prochlorperazine, an antiemetic neuroleptic drug, was found to reverse the depression of the ventilatory response to asphyxia caused by morphine. The drug significantly increased the ventilatory response to asphyxia, but did not affect resting ventilation or the ventilatory response to hypercapnia.
Paper Details　
Original Abstract of the Article :
Recent studies have shown that the antiemetic neuroleptic drug, prochlorperazine, is a potent stimulant of the ventilatory response to hypoxia. To investigate whether or not this effect persisted in the presence of central depression of ventilatory drive, the effects on ventilatory control of morphi...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
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引用元：
https://doi.org/10.1164/arrd.1986.133.4.558

データ提供：米国国立医学図書館（NLM）

The Balancing Act of Morphine and Prochlorperazine: A Journey Through the Respiratory Desert

Morphine is a potent pain reliever, but it can depress the respiratory system. Prochlorperazine, an antiemetic, has been shown to stimulate the ventilatory response to hypoxia. This study investigated the effects of combined morphine and prochlorperazine on ventilatory control in humans. The researchers examined the effects of these drugs on resting ventilation and the ventilatory responses to hypercapnia and asphyxia. The study is like navigating a desert where each step requires careful consideration of the terrain and potential risks.

Prochlorperazine: A Potential Oasis in the Morphine-Induced Respiratory Depression

The study found that prochlorperazine reversed the depression of the ventilatory response to asphyxia caused by morphine. This finding suggests that prochlorperazine could be a valuable tool for managing the respiratory side effects of morphine. This is like finding a hidden oasis in the desert, providing relief from the harsh conditions.

Navigating the Desert of Respiratory Control: A Balancing Act

This study highlights the importance of understanding the interactions between different drugs, especially those affecting the respiratory system. The researchers' findings emphasize the need for careful monitoring and management of patients receiving morphine, particularly those at risk for respiratory depression. This research serves as a reminder that navigating the desert of medicine requires careful consideration of the interplay between different elements.

Dr.Camel's Conclusion

This study reveals the potential of prochlorperazine to reverse the respiratory depression caused by morphine. It's like discovering a hidden oasis in the desert, providing relief from the harsh effects of morphine. This research underscores the importance of understanding drug interactions and finding solutions that create a balance in the human body.
Date :
  1. Date Completed 1986-05-01
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

3963624

DOI: Digital Object Identifier

10.1164/arrd.1986.133.4.558

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PICO Info
in preparation
Languages

English

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