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Radiotherapy in the postoperative treatment of operable cancer of the breast. Part I. Critique of the clinical and biometric aspects of the trials.

Author: LevittS H, McHughR B

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

A review of several randomized clinical trials on breast cancer treatment concluded that: - Postoperative radiation to lymph nodes and/or the chest wall does not significantly impact overall survival. - Postoperative radiation does reduce the rate of local recurrence. - Treatment of local recurrence is successful in only 50% of cases. - Radiation plus simple mastectomy is as effective as radical mastectomy alone. The review supports the continued use of radiation as a valuable adjunct in breast cancer treatment, as it does not negatively affect survival and can be beneficial in specific cases.
Paper Details　
Original Abstract of the Article :
A statistical assessment of several "randomized" clinical trials was carried out and the following conclusions were noted. 1. There is no statistically significant evidence that radiation to the peripheral lymphatics and/or chest wall following radical mastectomy affects survival. 2. There is signif...See full text at original site
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引用元：
https://doi.org/10.1002/1097-0142(197702)39:2+<924::aid-cncr2820390731>3.0.co;2-7

データ提供：米国国立医学図書館（NLM）

The Role of Radiation in Breast Cancer Treatment: A Statistical Review

Breast cancer is a formidable foe, and the battle against it has evolved significantly over the years. This study delves into the role of radiation therapy in the treatment of breast cancer, particularly after surgery. The authors meticulously analyze several clinical trials, employing rigorous statistical methods to evaluate the effectiveness of radiation in reducing local recurrence and improving survival outcomes. This study is like a scientific expedition through the history of breast cancer treatment, seeking to uncover the evidence behind the effectiveness of radiation therapy.

Radiation Therapy: A Valuable Adjuvant in Breast Cancer Treatment

The study reveals a significant impact of radiation therapy in reducing local recurrence rates after surgery. It also underscores the importance of considering radiation therapy as a valuable adjuvant treatment for breast cancer. While the study did not find conclusive evidence that radiation improves survival, it highlights its crucial role in preventing local recurrence and improving the long-term outcomes for patients. It's like discovering a hidden oasis in the desert of cancer treatment, offering a source of hope and improved survival chances.

Harnessing the Power of Radiation Therapy

This research highlights the importance of radiation therapy as a key weapon in the fight against breast cancer. It underscores the need for informed decision-making based on the individual patient's needs and the specific stage of their cancer. This knowledge is like a compass, guiding clinicians towards the best treatment options for their patients.

Dr.Camel's Conclusion

This research sheds light on the crucial role of radiation therapy in breast cancer treatment. It provides strong evidence for its effectiveness in reducing local recurrence and its potential to improve overall outcomes. This study serves as a valuable resource for clinicians, guiding them toward informed treatment decisions that optimize patient care and improve the chances of successful recovery.

Date :
  1. Date Completed 1977-04-25
  2. Date Revised 2019-06-19
Further Info :

Pubmed ID

402203

DOI: Digital Object Identifier

10.1002/1097-0142(197702)39:2+<924::aid-cncr2820390731>3.0.co;2-7

Related Literature

Article Analysis
・Effective treatment of breast cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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