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Comparative effects of delta 9-tetrahydrocannabinol, tetrabenazine and chlorpromazine on rectal temperature in the rat.

Author: DiamantisW, MeltonJ, SofiaR D

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Tetrabenazine produced a biphasic response in rectal temperature of rats, with an initial hyperthermia followed by hypothermia. This effect was similar to that of THC, supporting the idea that the two drugs act via similar mechanisms. Chlorpromazine, in contrast, only caused hypothermia.
Paper Details　
Original Abstract of the Article :
Tetrabenazine evoked a biphasic response in rectal temperature of the rat following intraperitoneal administration of 4.4--70.0 mg/kg. The initial hyperthermia was inversely related to the dose while the subsequent hypothermia was dose-dependent. This biphasic effect on temperature was similar to th...See full text at original site
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引用元：
https://doi.org/10.1159/000137260

データ提供：米国国立医学図書館（NLM）

Exploring the Brain's Response to Different Drugs: A Tale of Two Temperatures

This study investigated the effects of different drugs, including delta 9-tetrahydrocannabinol (THC), tetrabenazine, and chlorpromazine, on rectal temperature in rats. It's like a scientific investigation into the brain's delicate thermostat, exploring how different substances can alter its temperature settings.

Temperature Fluctuations

The study found that THC and tetrabenazine caused both hyperthermia (increased body temperature) and hypothermia (decreased body temperature), while chlorpromazine only induced hypothermia. It's like observing how different types of sand dunes shift and change under the influence of different winds.

Understanding Drug Effects

This research provides valuable insights into the diverse effects of different drugs on body temperature, highlighting the complex interplay between drugs and the brain's regulatory mechanisms. It's like a map of the brain's thermostat, revealing how different drugs can influence its delicate balance.

Dr.Camel's Conclusion

This study offers a fascinating glimpse into the brain's temperature regulation and how different drugs can influence this complex process. It highlights the importance of understanding these effects for developing safe and effective medications.

Date :
  1. Date Completed 1979-11-21
  2. Date Revised 2018-02-14
Further Info :

Pubmed ID

482345

DOI: Digital Object Identifier

10.1159/000137260

Related Literature

Article Analysis
・Effects of tetrabenazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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