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Original Abstract of the Article :
Ninety patients with duodenal ulcer, divided randomly into three groups, were treated continuously for one year with either glycopyrronium, 1-hyoscyamine (as a sustained-release preparation) or inert tablets. Dosage with active tablets was so adjusted that the patient experienced definite but tolera...See full text at original site
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引用元：
https://doi.org/10.1136/gut.10.10.774
データ提供：米国国立医学図書館（NLM）
Gastric Acid Secretion: A Balancing Act in the Desert of Ulcers
Duodenal ulcers, painful sores in the upper part of the small intestine, can be a source of discomfort and disruption. This study investigates the effects of prolonged anticholinergic therapy, a treatment approach that reduces stomach acid production, on gastric acid secretion in patients with duodenal ulcers.
Anticholinergics: A Balancing Act in the Desert of Ulcers
The researchers randomly assigned 90 patients with duodenal ulcers to three groups: two groups received anticholinergic medications (glycopyrronium or hyoscyamine) and one group received inert tablets. They measured basal and maximal gastric acid secretion before and after a year of treatment. The study found that glycopyrronium led to a significant increase in basal gastric acid secretion, suggesting that prolonged anticholinergic therapy might have unexpected effects on acid production.
Anticholinergics: A Balancing Act in the Desert of Ulcers
The researchers also observed fluctuations in maximal acid output across all groups, suggesting that spontaneous changes in parietal cell mass, the cells responsible for acid production, may occur in patients with duodenal ulcers. The study's findings highlight the complexity of gastric acid regulation and emphasize the need for ongoing monitoring and individualization of treatment approaches to manage duodenal ulcers effectively.
Dr. Camel's Conclusion
This research provides valuable insights into the effects of prolonged anticholinergic therapy on gastric acid secretion in patients with duodenal ulcers. The study's findings suggest that prolonged anticholinergic therapy may not always lead to a reduction in gastric acid secretion and that individual responses to treatment can vary significantly. Further research is needed to explore the long-term effects of anticholinergic therapy and to develop more effective treatment strategies for managing duodenal ulcers.
Date :
- Date Completed 1969-12-30
- Date Revised 2019-05-01
Further Info :
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