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Effects of auranofin on leukotriene production and leukotriene stimulated neutrophil function.

Author: HafströmI, MalmstenC, PalmbladJ, RingertzB

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Auranofin did not inhibit leukotriene production but modulated neutrophil aggregation, enzyme release, and chemotaxis induced by leukotrienes. This suggests that auranofin might exert some of its antirheumatic effects through leukotriene modulation.
Paper Details　
Original Abstract of the Article :
Arachidonic acid is metabolized in neutrophils by lipoxygenase to leukotrienes, which are suggested to play a central role in inflammation. The antirheumatic drug auranofin (4 micrograms/ml) was found not to inhibit neutrophil production of the lipoxygenase products 5-HETE-, 15-HETE and LTB4, in vit...See full text at original site
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引用元：
https://doi.org/10.1007/BF01966773

データ提供：米国国立医学図書館（NLM）

Auranofin: A Journey Through the Desert of Inflammation

This research explores the fascinating landscape of inflammation, investigating the effects of auranofin on leukotriene production and neutrophil function. The authors examined the impact of this antirheumatic drug on the production and modulation of leukotrienes, which play a central role in inflammatory responses.

Navigating the Desert of Leukotriene Modulation

The research revealed that while auranofin did not inhibit neutrophil production of leukotrienes, it did modulate neutrophil aggregation, enzyme release, and chemotaxis induced by leukotrienes. These findings provide valuable insights into the potential mechanisms of action of auranofin in managing inflammation.

Dr. Camel's Conclusion

This research unveils the intricate interplay between auranofin and leukotrienes, offering potential explanations for its antirheumatic effects. It highlights the importance of understanding the complex mechanisms of inflammation and the role of specific mediators like leukotrienes in driving inflammatory responses.

Date :
  1. Date Completed 1985-05-08
  2. Date Revised 2019-08-25
Further Info :

Pubmed ID

6099693

DOI: Digital Object Identifier

10.1007/BF01966773

Related Literature

Article Analysis
・Effects of auranofin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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