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A combination of oral and topical beta-blockers with additive effects on intraocular pressure.

Author: KättströmO, OhrströmA

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Adding oral propranolol to topical timolol treatment for glaucoma lowered intraocular pressure significantly. The effect may be due to a loss of efficacy of topical beta-blockers, which oral propranolol restores.
Paper Details　
Original Abstract of the Article :
In a double-masked randomised cross-over study the effect of adding oral propranolol (40 mg X 2) to topical timolol-treatment (0.5% X 2) was evaluated. Ten patients with glaucoma or ocular hypertension (totally 15 pathological eyes and 5 healthy) who had had topical timolol for at least 2 months rec...See full text at original site
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引用元：
https://doi.org/10.1111/j.1755-3768.1983.tb01490.x

データ提供：米国国立医学図書館（NLM）

Combating Glaucoma: Combining Oral and Topical Beta-Blockers

This study delves into the field of [ophthalmology] and explores the potential of combining oral and topical beta-blockers to effectively manage intraocular pressure, a key factor in glaucoma. The researchers conducted a double-masked randomized cross-over study to investigate the effects of adding oral propranolol to topical timolol treatment. They found that combining these medications resulted in a significant decrease in intraocular pressure, suggesting that this combination could be an effective strategy for managing glaucoma. This study contributes valuable insights into the potential benefits of a multi-modal approach to glaucoma management.

A Novel Strategy for Glaucoma Management

The study found that combining oral propranolol with topical timolol resulted in a significant reduction in intraocular pressure. This synergistic effect suggests that combining these medications could offer a more effective approach to managing glaucoma, potentially improving treatment outcomes and slowing disease progression.

Protecting Vision Through Effective Treatment

This research underscores the importance of exploring novel and effective treatment strategies for glaucoma. The findings suggest that combining oral and topical beta-blockers could be a valuable approach to managing intraocular pressure, potentially improving vision outcomes and preserving eye health.

Dr.Camel's Conclusion

This research, like a camel navigating a vast desert landscape, reveals a potential path to improved vision care. Combining oral and topical beta-blockers offers a promising approach to managing glaucoma, potentially protecting vision and enhancing the quality of life for individuals with this condition. This research encourages continued exploration of multi-modal approaches to glaucoma management, seeking the most effective strategies to preserve vision and combat this challenging disease.

Date :
  1. Date Completed 1984-02-22
  2. Date Revised 2019-08-21
Further Info :

Pubmed ID

6140811

DOI: Digital Object Identifier

10.1111/j.1755-3768.1983.tb01490.x

Related Literature

Article Analysis
・Effects of timolol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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