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Operation of long-range substituent effects in rigid opiates: protonated and unprotonated oxymorphone.
Author: DarlingS D, KolbV M, MandelG S, MandelN S
Original Abstract of the Article :
The structure of protonated oxymorphone (amine salt) was determined by an X-ray crystallographic study. Significant differences were found with the previously determined structure of unprotonated oxymorphone (free base). Upon protonation on nitrogen, an elongation of the N-C bound occurred, accompan...See full text at original site
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引用元:
https://doi.org/10.1002/jps.2600710711
データ提供:米国国立医学図書館(NLM)
Operation of Long-Range Substituent Effects in Rigid Opiates: Protonated and Unprotonated Oxymorphone
The world of chemistry is a fascinating landscape of molecules and their interactions. This research delves into the intricacies of opiate chemistry, specifically focusing on the structure of oxymorphone, a potent opioid analgesic, in both its protonated and unprotonated forms. The researchers used X-ray crystallography, a powerful technique that allows us to visualize the three-dimensional structure of molecules, to understand how protonation affects the geometry of oxymorphone. Their findings revealed significant differences in the molecular structure of oxymorphone depending on its protonation state, highlighting the importance of understanding these subtle changes.Oxymorphone: A Chemical Oasis in the Desert of Opiate Research
This research, like a chemist carefully analyzing the intricate structure of a molecule, explores the molecular geometry of oxymorphone, a potent opioid. The researchers' findings reveal that even subtle changes in protonation can significantly affect the molecule's structure, highlighting the importance of understanding these intricate details. Their analysis provides valuable insights into the relationship between molecular structure and biological activity, advancing our understanding of how opiates interact with the body.Navigating the Complexities of Opiate Chemistry: A Quest for Understanding
The study highlights the importance of understanding the chemical properties of drugs to optimize their effectiveness and minimize potential side effects. Dr. Camel recognizes that the field of drug development is constantly evolving, driven by a desire to develop safer and more effective therapies. This research is a testament to the ongoing quest for knowledge in the world of chemistry, enabling us to develop better drugs and treat patients more effectively.Dr. Camel's Conclusion
This research is a reminder that the world of chemistry is a complex and fascinating landscape. Dr. Camel, with his deep appreciation for the intricate beauty of molecules, believes that this study will contribute to our understanding of how opiates interact with the body, leading to the development of better and safer treatments for pain.Date :
- Date Completed 1982-12-02
- Date Revised 2019-07-11
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