Comparison in rats of the anti-inflammatory and gastric irritant effects of etodolac with several clinically effective anti-inflammatory drugs.

Author: KliciusJ, MartelR R

Paper Details 
Original Abstract of the Article :
The anti-inflammatory and gastric effects of etodolac were compared in the rat with those of seven clinically established nonsteroidal anti-inflammatory drugs. The anti-inflammatory potency of etodolac was found to lie between that of sulindac and piroxicam. Etodolac was 2.8 times more active than s...See full text at original site
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引用元:
https://doi.org/10.1007/BF01965392

データ提供:米国国立医学図書館(NLM)

Etodolac: A Potent Anti-Inflammatory Drug with High Gastric Tolerance

The field of [Pharmacology] seeks to develop [effective and safe medications] for [inflammatory conditions]. This research compares the [anti-inflammatory potency] and [gastric irritation] of [etodolac] to a group of [clinically established nonsteroidal anti-inflammatory drugs (NSAIDs)]. The authors conducted a [series of experiments in rats] to evaluate the [relative efficacy and gastrointestinal side effects] of [etodolac] compared to other [NSAIDs]. Their results suggest that [etodolac] exhibits a [favorable balance] between [anti-inflammatory activity] and [gastric tolerance], demonstrating its potential as a [well-tolerated and effective NSAID].

Balancing Efficacy and Safety in NSAID Therapy

This research highlights the importance of [balancing efficacy and safety] in the development and selection of [NSAIDs]. The findings suggest that [etodolac] may offer a [favorable therapeutic index], providing [effective pain relief] with a [reduced risk of gastrointestinal complications].

Navigating NSAID Use: A Balanced Approach

While [NSAIDs] can provide [relief from pain and inflammation], it is crucial to [use them responsibly and under medical supervision]. [Long-term use] of [NSAIDs] can increase the risk of [gastrointestinal complications], and it is essential to [monitor for any adverse effects] and to [discuss any concerns] with your [healthcare provider].

Dr.Camel's Conclusion

This research is like finding a sturdy camel with a gentle nature, providing effective pain relief without causing excessive stomach upset. Etodolac's unique balance between potency and safety offers a potentially more comfortable journey through the desert of inflammation.

Date :
  1. Date Completed 1982-12-21
  2. Date Revised 2019-08-25
Further Info :

Pubmed ID

6215841

DOI: Digital Object Identifier

10.1007/BF01965392

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Article Analysis
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Languages

English

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