Paper Details

  1. Home
  2. Paper Details

CI-906 and CI-907: new orally active nonsulfhydryl angiotensin-converting enzyme inhibitors.

Author: CohenD M, EssenburgA D, KaplanH R, MajorT C, MertzT E, RyanM J

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

CI-906 and CI-907, new angiotensin-converting enzyme inhibitors, demonstrated potent, orally active ACE inhibition in guinea pig serum, isolated rabbit aortic rings, and in vivo rat and dog studies. They showed antihypertensive effects in hypertensive rats and dogs with no apparent side effects.
Paper Details　
Original Abstract of the Article :
CI-906, [3S-[2[R*(R*)]], 3R*]-2-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]-amino]-1-oxopropyl] 1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid, monohydrochloride, and CI-907, [2S-[1[R*(R*)]], 2 alpha, 3a beta, 7a 7a beta]-1-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino] 1-oxopropyl]octahydro-1H-indole-...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/6323223

データ提供：米国国立医学図書館（NLM）

New Angiotensin-Converting Enzyme Inhibitors

This study explores the potential of new nonsulfhydryl-type angiotensin-converting enzyme (ACE) inhibitors, CI-906 and CI-907, as promising treatments for hypertension and other conditions. The researchers conducted various experiments, like meticulously mapping out a desert route, to evaluate the compounds’ effectiveness. They found that these inhibitors were highly specific in blocking the actions of angiotensin I, a key player in blood pressure regulation.

Potential for Effective Treatment

This study suggests that these new ACE inhibitors could be valuable additions to the therapeutic arsenal for hypertension and other conditions.

Understanding Blood Pressure Regulation

This study provides valuable insights into the complex mechanisms of blood pressure regulation and the potential for new treatments. It is a reminder that we must continue to explore innovative approaches to address cardiovascular health challenges.

Dr.Camel's Conclusion

This study unveils promising new nonsulfhydryl-type angiotensin-converting enzyme (ACE) inhibitors that could offer effective treatment for hypertension and other conditions. It is a testament to the ongoing efforts of researchers to improve our understanding of the human body and develop better medical solutions.

Date :
  1. Date Completed 1984-05-24
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

6323223

DOI: Digital Object Identifier

6323223

Related Literature

Article Analysis
・Side Effects of quinapril
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.