Antihypertensive profile of the angiotensin-converting enzyme inhibitors CI-906 and CI-907.

Author: BoucherD M, CohenD M, KaplanH R, OlszewskiB J, RyanM J, SingerR M, SmithR D

Paper Details 
Original Abstract of the Article :
CI-906 and CI-907, new orally active nonsulfhydryl angiotensin-converting enzyme inhibitors, were examined for antihypertensive effects in unanesthetized hypertensive rats and dogs. In two-kidney, one-clip Goldblatt hypertensive rats, single oral daily doses (0.03-30 mg/kg) produced dose-dependent d...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/6323224

データ提供:米国国立医学図書館(NLM)

Exploring the Potential of CI-906 and CI-907 as Antihypertensive Agents

The search for effective and safe treatments for hypertension, a condition that affects millions worldwide, is a continuous journey. This study investigates two new orally active nonsulfhydryl angiotensin-converting enzyme (ACE) inhibitors, CI-906 and CI-907, for their potential as antihypertensive agents.

The researchers tested these inhibitors on both two-kidney, one-clip Goldblatt hypertensive rats and spontaneously hypertensive rats. Their results showed that both CI-906 and CI-907 significantly lowered blood pressure in a dose-dependent manner, indicating their effectiveness as antihypertensive agents. They also found that these inhibitors did not exhibit any apparent side effects in conscious animals.

A Promising New Approach to Blood Pressure Management

The results of this study are encouraging, as they suggest that CI-906 and CI-907 might provide a new and potentially safer alternative to current antihypertensive treatments. The lack of observable side effects in the study is particularly noteworthy. This could be a significant step forward in the treatment of hypertension, a condition that affects millions worldwide.

The Importance of Research and Development in Hypertension Treatment

This study serves as a reminder of the ongoing need for research and development in the field of hypertension treatment. The discovery of new and potentially safer medications like CI-906 and CI-907 could make a significant difference in the lives of countless individuals struggling with this common and often serious condition. It's a reminder that even in a seemingly vast and uncharted desert of medical research, there are always hidden oases of innovation waiting to be discovered.

Dr.Camel's Conclusion

This study, like a refreshing oasis in the vast desert of hypertension research, offers promising new avenues for treatment. The discovery of CI-906 and CI-907 as potential antihypertensive agents with no observed side effects is a beacon of hope for millions struggling with this condition. It's a reminder that even in the face of complex and persistent health challenges, the pursuit of knowledge and innovation can pave the way for brighter horizons.

Date :
  1. Date Completed 1984-05-24
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

6323224

DOI: Digital Object Identifier

6323224

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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