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Suppression of frequently recurring genital herpes. A placebo-controlled double-blind trial of oral acyclovir.

Author: BachrachS, Creagh-KirkT, DiGiovannaJ J, LehrmanS N, LiningerL, SeidlinM, SmithH A, StrausS E, TakiffH E, WesternK A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Oral acyclovir was effective in suppressing recurrent genital herpes in patients experiencing frequent outbreaks, with significantly fewer recurrences compared to placebo (4/16 vs. 16/16). The treatment was well tolerated, with minimal side effects. However, drug resistance emerged in some patients during treatment, highlighting the need for further research on long-term safety and potential strategies to manage resistance.
Paper Details　
Original Abstract of the Article :
We studied 35 otherwise healthy adults with frequently recurring genital herpes (greater than or equal to 1 episode per month), in a double-blind trial comparing oral acyclovir with placebo capsules for suppression of recurrent infection. The patients were treated for 125 days unless herpes recurred...See full text at original site
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引用元：
https://doi.org/10.1056/NEJM198406143102401

データ提供：米国国立医学図書館（NLM）

Genital Herpes: Seeking a Oasis in the Desert of Recurrence

Genital herpes is a common and recurring infection, often causing discomfort and frustration. This study explores the use of oral acyclovir in suppressing these frequent recurrences, comparing it to a placebo. The authors sought to determine the effectiveness of this treatment in managing recurrent genital herpes.

Finding Relief from Recurrences

The study found that oral acyclovir was significantly more effective in suppressing recurrent genital herpes compared to the placebo. This is like finding an oasis in a desert, offering relief from the constant discomfort of recurring outbreaks. The researchers also observed potential for drug resistance and the need for long-term safety monitoring, highlighting the importance of using this treatment cautiously and strategically.

Managing Genital Herpes: A Desert Traveler's Guide

If you are experiencing recurrent genital herpes, it's important to seek medical advice. There are various treatment options available, and a doctor can help you determine the best course of action. Remember, just as a desert traveler needs to be prepared for the journey, it's essential to stay informed and take steps to manage your health.

Dr.Camel's Conclusion

Genital herpes can be a challenging condition, but this study offers hope for managing its recurring nature. While oral acyclovir shows promise, it's crucial to approach treatment with caution and stay informed about potential side effects and drug resistance. By working closely with your doctor, you can find a way to navigate the desert of recurrent herpes and find relief from its discomfort.

Date :
  1. Date Completed 1984-07-09
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

6328297

DOI: Digital Object Identifier

10.1056/NEJM198406143102401

Related Literature

Article Analysis
・Effective treatment of genital herpes
SNS
PICO Info
in preparation
Languages

English

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