Paper Details

  1. Home
  2. Paper Details

Penbutolol in hypertension, alone and in combination with furosemide. A long-term multicentre study.

Author: LawrenceJ, MertensH, RössnerM, Vander ElstE

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

Penbutolol is a new long-acting beta-blocker that is effective in treating moderate hypertension. Two-thirds of patients in this study showed good blood pressure control with penbutolol alone, and the rest benefited from a combination of penbutolol and furosemide. The drug was well tolerated, with only minor gastrointestinal side effects reported. One patient with chronic glomerulonephritis experienced renal function deterioration, which might be related to the disease progression.
Paper Details　
Original Abstract of the Article :
Penbutolol is a new, potent and long-acting non-cardioselective beta-adrenergic blocker which has been evaluated in a 6-month open study of patients with moderate essential or renal hypertension. Eighty-two patients entered the study and 69 completed at least 3 months of treatment. Two-thirds of the...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/6336854

データ提供：米国国立医学図書館（NLM）

Penbutolol in Hypertension, Alone and in Combination with Furosemide. A Long-Term Multicentre Study

Hypertension, a silent but dangerous condition, affects millions of people worldwide. This study, published in [Journal Name], explores the effectiveness of a medication called penbutolol in managing hypertension, both alone and in combination with another drug, furosemide.

Penbutolol Shows Promise in Managing Hypertension

The study, conducted across multiple centers, investigated the long-term effects of penbutolol on patients with moderate essential or renal hypertension. The researchers found that penbutolol, like a soothing balm in the desert heat, effectively reduced blood pressure in a significant proportion of patients, with the majority of patients experiencing a sustained reduction in blood pressure over the six-month study period. The study also found that combining penbutolol with furosemide resulted in satisfactory blood pressure control in most patients, suggesting a potential synergistic effect between these medications.

Navigating the Side Effects of Penbutolol Treatment

While penbutolol was generally well-tolerated, some patients experienced gastrointestinal side effects at the beginning of treatment, which resolved over time. The study also highlights the importance of monitoring renal function in patients with chronic glomerulonephritis, as one patient experienced a deterioration in renal function during the study, potentially related to disease progression.

Dr. Camel's Conclusion

This research offers valuable insights into the effectiveness of penbutolol in managing hypertension, providing a potential avenue for improving the lives of patients with this prevalent condition. The findings highlight the importance of personalized treatment approaches, carefully considering the individual needs and potential side effects of specific medications. The study's results serve as a reminder of the complex nature of hypertension management, urging us to continue searching for innovative and effective treatment options.
Date :
  1. Date Completed 1983-02-25
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

6336854

DOI: Digital Object Identifier

6336854

Related Literature

Article Analysis
・Side Effects of penbutolol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.