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Clinical therapeutic trial of sodium meclofenamate and naproxen in rheumatoid arthritis, with comments on the use of placebos in clinical trials.

Author: BuchananW W, GraceE M, MewaA, RooneyP J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Sodium meclofenamate and naproxen were equally effective and well tolerated in patients with active rheumatoid arthritis. Both drugs showed significant improvements in articular index, grip strength, and pain severity.
Paper Details　
Original Abstract of the Article :
Forty patients with active rheumatoid arthritis were entered into a single-blind study of 12-weeks' duration to compare the efficacy and tolerance of 100 mg sodium meclofenamate 3-times daily and 250 mg naproxen twice daily. Disease activity was defined by the presence of a Ritchie Articular Index s...See full text at original site
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引用元：
https://doi.org/10.1185/03007998309111748

データ提供：米国国立医学図書館（NLM）

Sodium Meclofenamate vs. Naproxen: A Battle in the Desert of Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a debilitating disease that affects millions of people worldwide. This research compares the effectiveness and safety of two common medications: sodium meclofenamate and naproxen. It's like exploring two different paths through the desert of RA treatment, seeking the most effective route to relief.

The researchers conducted a single-blind study on 40 patients with active RA. They compared the effects of sodium meclofenamate and naproxen over a 12-week period. This study was like comparing the growth of two different plants in a desert – observing how each medication affected the RA symptoms.

A Balanced Outcome in the Desert

The researchers found that both sodium meclofenamate and naproxen showed significant improvements in RA symptoms, but there was no significant difference between the two treatments. This suggests that both medications offer similar benefits in the treatment of RA. It's like finding two equally fertile oases in the desert – both offering nourishment and relief.

Finding the Right Oasis in the Desert

Choosing the right medication for RA depends on individual factors, including potential side effects and personal preferences. It's important to consult with a doctor to determine the best treatment option. This research helps to inform those decisions and guide patients towards a more comfortable journey through the desert of RA.

Dr.Camel's Conclusion

This study reveals that sodium meclofenamate and naproxen provide similar relief for patients with rheumatoid arthritis. It's like finding two paths through the desert that lead to the same destination. The choice between these medications ultimately depends on individual needs and preferences. Further research is needed to explore long-term effects and the potential benefits of different combinations of treatments.

Date :
  1. Date Completed 1983-07-15
  2. Date Revised 2019-09-08
Further Info :

Pubmed ID

6342956

DOI: Digital Object Identifier

10.1185/03007998309111748

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・Side Effects of meclofenamate
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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