Side Effects of meclofenamate: A Synthesis of Findings from 13 Studies

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Original Abstract of the Article

Key Research Findings

Meclofenamate is a nonsteroidal anti-inflammatory drug (NSAID) that has been studied for its effectiveness and safety in treating a range of conditions. Studies have shown that meclofenamate is generally effective in treating conditions such as rheumatoid arthritis, post-episiotomy pain, dental pain, and recurrent nephrotic syndrome, but it also comes with a number of side effects. 3 , 12 , 7 , 6 , 9 , 13 , 4 , 2 , 8 , 10 , 11 , 5 , 1

Reasons for Side Effects

Meclofenamate works by inhibiting the production of prostaglandins, which are important for reducing pain and inflammation. However, prostaglandins also play a role in protecting the stomach lining and regulating blood flow in the kidneys. Therefore, blocking prostaglandin production can lead to side effects such as gastrointestinal problems and kidney problems. 11 , 10

Common Side Effects

Gastrointestinal

Meclofenamate commonly causes gastrointestinal side effects such as diarrhea, abdominal pain, nausea, and vomiting. 3 , 7 , 6 , 4 , 2 , 8 , 10 , 5 , 1

Liver

In some cases, meclofenamate can cause liver problems such as liver dysfunction and jaundice. 3

Kidney

Meclofenamate may affect the kidneys, potentially leading to kidney dysfunction and kidney failure. 13 , 10

Blood

Meclofenamate can sometimes affect the blood, causing anemia and leukopenia. 3

Other

Other reported side effects of meclofenamate include dizziness, headache, drowsiness, tinnitus, rash, and urticaria. 3 , 7 , 2 , 8 , 5

Countermeasures for Side Effects

Gastrointestinal

To minimize gastrointestinal side effects, it's recommended to take meclofenamate after meals, consume milk or yogurt, and consider using antacids. 3 , 4

Liver

Before starting meclofenamate treatment, a liver function test should be performed. If you have any liver abnormalities, it's crucial to avoid meclofenamate. 3

Kidney

A kidney function test is recommended prior to taking meclofenamate. If you have any kidney issues, meclofenamate should be avoided. 13 , 10

Blood

Before beginning treatment, a blood test should be conducted. If your blood shows any abnormalities, you should avoid meclofenamate. 3

Comparison Between Studies

Common Points of Studies

Many studies indicate that meclofenamate is effective for various conditions and that side effects are generally mild. 3 , 12 , 7 , 6 , 9 , 13 , 4 , 2 , 8 , 10 , 11 , 5 , 1

Differences Between Studies

The frequency and severity of meclofenamate side effects can vary between studies. This variability may be attributed to factors like the patient population, dosage, type of condition being treated, and other medications being taken concurrently. 3 , 7 , 6 , 4 , 2 , 8 , 10 , 5 , 1

Points to Note for Application in Real Life

Meclofenamate is a helpful drug, but it's essential to understand the potential for side effects. Before taking meclofenamate, consult with your doctor to determine if it's appropriate for you. While taking meclofenamate, strictly adhere to your doctor's instructions and avoid stopping or altering your dosage without their guidance. 3 , 7 , 6 , 4 , 2 , 8 , 10 , 5 , 1

Current Research Limitations

Research on the side effects of meclofenamate is still limited. More research is needed, particularly on long-term side effects, as well as the variability of side effects among individuals. 3 , 7 , 6 , 4 , 2 , 8 , 10 , 5 , 1

Future Research Directions

Further research is crucial to delve deeper into the long-term side effects of meclofenamate, individual variations in response, and drug interactions. Additionally, developing new methods to mitigate the side effects of meclofenamate is a critical area of focus. 3 , 7 , 6 , 4 , 2 , 8 , 10 , 5 , 1

Conclusion

Meclofenamate is an effective medication for a variety of conditions, but understanding the possibility of side effects is important. When considering meclofenamate, consult your doctor to ensure it's the right choice for you. 3 , 7 , 6 , 4 , 2 , 8 , 10 , 5 , 1

Literature analysis of 13 papers
Positive Content
11
Neutral Content
0
Negative Content
2
Article Type
6
0
0
0
13
1.

Steatorrhea associated with meclofenamate sodium therapy.

Author: MoellerD D

Diarrhea
Gastrointestinal side effects
Malabsorption
Steatorrhea

Fenamates, a class of nonsteroidal anti-inflammatory drugs, can cause gastrointestinal side effects, including diarrhea and, rarely, malabsorption. A case of steatorrhea due to meclofenamate sodium is reported.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

2.

Single dose and multidose analgesic study of ibuprofen and meclofenamate sodium after third molar surgery.

Author: HershE V, CooperS, BettsN, WedellD, MacAfeeK, QuinnP, LampC, GastonG, BergmanS, HenryE

Effective analgesia
Diarrhea
Stomach cramps

Meclofenamate sodium and ibuprofen were compared for their analgesic efficacy and safety after dental impaction surgery. Higher doses of both drugs were most effective initially, with meclofenamate 100 mg and ibuprofen 400 mg demonstrating the greatest efficacy. While both drugs were effective after the first postoperative day, meclofenamate was associated with a higher incidence of stomach cramps and diarrhea.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

The relative toxicity of nonsteroidal antiinflammatory drugs.

Author: FriesJ F, WilliamsC A, BlochD A

Gastrointestinal toxicity

Nonsteroidal anti-inflammatory drugs (NSAIDs) varied significantly in toxicity, with indomethacin, tolmetin sodium, and meclofenamate sodium being the most toxic.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

4.

Double-blind multicenter studies with meclofenamate sodium in the treatment of rheumatoid arthritis in the United States and Canada.

Author: PetrickT J, BlackM E

Effective treatment
Superior to placebo
Diarrhea
Gastrointestinal reactions

Meclofenamate sodium was as effective as acetylsalicylic acid and superior to placebo in treating rheumatoid arthritis. It was well tolerated, although gastrointestinal side effects were more common than with acetylsalicylic acid.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Clinical therapeutic trial of sodium meclofenamate and naproxen in rheumatoid arthritis, with comments on the use of placebos in clinical trials.

Author: GraceE M, MewaA, RooneyP J, BuchananW W

Improved articular index
Improved global assessment
Improved grip strength
Reduced pain severity
Inadequate efficacy
Nausea

Sodium meclofenamate and naproxen were equally effective and well tolerated in patients with active rheumatoid arthritis. Both drugs showed significant improvements in articular index, grip strength, and pain severity.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Sodium meclofenamate (Meclomen) in the treatment of juvenile rheumatoid arthritis. A segment I study.

Author: BrewerE J, GianniniE H, BaumJ, CassidyJ T, FinkC W, HansonV, LevinsonJ E, SchallerJ G

Juvenile rheumatoid arthritis treatment
Adverse side effects

Sodium meclofenamate, a nonsteroidal anti-inflammatory drug, showed statistically significant decreases in disease indices, particularly morning stiffness, in patients with juvenile rheumatoid arthritis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

7.

Double-blind comparison of meclofenamate sodium with codeine and placebo for the pain of episiotomy.

Author: YonkeuraM L, PetroneS, TurnerJ L, di ZeregaG S

Pain relief
Safe and effective
Minimal side effects

Meclofenamate sodium, at both 100 mg and 200 mg doses, was significantly more effective in reducing episiotomy pain than codeine or placebo. All treatments were well-tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Comparison of meclofenamate sodium with buffered aspirin and placebo for the relief of postoperative dental pain.

Author: KempfK K, KonzelmanJ L, SchultzR E, TurnerJ L

Pain relief
Safe and effective
Minimal side effects

Meclofenamate sodium, at both 100 mg and 200 mg doses, was found to be a significantly more effective analgesic for acute pain following third-molar extraction than buffered aspirin or placebo. All treatments were well tolerated, with minimal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Control of pain with meclofenamate sodium following removal of an impacted molar.

Author: RoweN H, AseltineL F, TurnerJ L

Pain Relief

Meclofenamate sodium is a safe and effective analgesic for the control of pain after dental surgery. It provides significantly greater pain relief than placebo or aspirin.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Effects of meclofenamate and acetaminophen on abdominal pain following tubal occlusion.

Author: HuangK C, WolfeW M, TsuedaK, SimpsonP M, CaissieK F

Postoperative pain relief
None reported

Meclofenamate was more effective than acetaminophen in reducing postoperative abdominal pain after tubal occlusion. It also provided substantial analgesia for 4 hours.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

The effect of modulating the synthesis of arachidonic acid cascade products on HSV lesion recurrence.

Author: YatesF, CentifantoY M, CaldwellD R

HSV Recurrence Treatment
Steroid Side Effects

This study investigated the effectiveness of various drugs in preventing the recurrence of HSV lesions in mice. Topical steroids were most effective at initially reducing lesion number, while meclofenamate was most effective by day 5. NDGA was least effective, and chlorpromazine had similar efficacy to steroids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Meclofenamate treatment of recurrent idiopathic nephrotic syndrome with focal segmental glomerulosclerosis after renal transplantation.

Author: TorresV E, VelosaJ A, HolleyK E, FrohnertP P, ZinckeH, SterioffS

Effective for FSGS
Potential side effects

Mclofenamate may be beneficial in treating corticosteroid-resistant nephrotic syndrome with focal segmental glomerulosclerosis (FSGS), but careful supervision is essential due to potential side effects.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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