Double-blind multicenter studies with meclofenamate sodium in the treatment of rheumatoid arthritis in the United States and Canada.

Author: BlackM E, PetrickT J

Paper Details 
Original Abstract of the Article :
The therapeutic efficacy of N-(2,6-dichloro-m-tolyl)anthranilic acid, sodium salt (meclofenamate sodium, Meclomen) in the management of rheumatoid arthritis was clearly established in four large, double-blind, controlled multicenter studies in 757 patients. In one study, 200 mg/day of meclofenamate ...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/6349646

データ提供:米国国立医学図書館(NLM)

Rheumatoid Arthritis: A Persistent Challenge

Rheumatoid arthritis (RA), a chronic autoimmune disorder, can cause significant pain, stiffness, and joint damage. This research investigates the efficacy and safety of meclofenamate sodium, a nonsteroidal anti-inflammatory drug (NSAID), in treating RA.

The authors conducted four large, double-blind, controlled multicenter studies to compare the effectiveness of meclofenamate sodium to placebo and other NSAIDs, including acetylsalicylic acid (ASA), in managing RA. Their findings provide valuable insights into the potential benefits and limitations of meclofenamate sodium for treating RA.

Managing Pain and Inflammation: A Balancing Act

The research demonstrates that meclofenamate sodium is an effective and safe treatment option for RA, providing comparable efficacy to ASA and superior outcomes to placebo. However, the study also highlights the potential for gastrointestinal side effects, particularly diarrhea, emphasizing the need for careful monitoring and individualized dosing strategies.

Living with Rheumatoid Arthritis: A Collaborative Approach

This research underscores the importance of comprehensive management for individuals with RA, encompassing medication, lifestyle modifications, and physical therapy. It emphasizes the need for ongoing research and development to find new and safer treatment options for RA, improving the lives of those affected by this debilitating condition.

Dr.Camel's Conclusion

Just as a camel adapts to the harsh desert environment, managing rheumatoid arthritis requires a persistent and multifaceted approach. This research offers valuable insights into the efficacy and safety of meclofenamate sodium, providing a valuable tool for healthcare providers and patients alike in their quest for managing this challenging condition.

Date :
  1. Date Completed 1983-09-20
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

6349646

DOI: Digital Object Identifier

6349646

Related Literature

SNS
PICO Info
in preparation
Languages

English

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