Paper Details

  1. Home
  2. Paper Details

Variables predictive of successful medical therapy in patients with unstable angina: selection by multivariate analysis from clinical, electrocardiographic, and angiographic evaluations.

Author: BrinkerJ A, GerstenblithG, MellitsE D, OuyangP, WeisfeldtM L

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study investigated the effectiveness of adding nifedipine to standard treatment for unstable angina. The study found that patients with more severe coronary artery blockage (70% or greater stenosis) had a higher risk of needing surgery, experiencing a heart attack, or dying. Nifedipine was found to reduce the risk of failing medical therapy by half, particularly in patients with two or more stenotic vessels or with 50% or more of their heart supplied by severely narrowed vessels. While nifedipine did not prevent heart attacks or death, it did significantly reduce the need for bypass surgery.
Paper Details　
Original Abstract of the Article :
Although unstable angina can be initially controlled with medical therapy in most patients, there is a high incidence of subsequent death, myocardial infarction, or need for coronary bypass surgery to control symptoms. Identification at the time of presentation of the patient likely to do poorly on ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1161/01.cir.70.3.367

データ提供：米国国立医学図書館（NLM）

Predicting Successful Medical Therapy in Unstable Angina

Unstable angina, a serious cardiovascular condition, is like a sudden sandstorm in the desert, threatening the health of the heart. Researchers are constantly working to find effective treatments for this condition and prevent its progression.

This study investigates variables predictive of successful medical therapy in patients with unstable angina. The authors used multivariate analysis to identify factors that influence response to treatment. Imagine these variables as different landmarks in the desert, each offering clues about the terrain of the disease. The study focuses on the role of coronary arterial spasm and the potential benefits of calcium channel antagonists in managing unstable angina.

Key Factors in Predicting Treatment Success

This study identifies several key factors that influence the success of medical therapy in unstable angina. The authors found that the percentage of left ventricular myocardium supplied by vessels with 70% or greater luminal stenosis was the most significant variable in influencing treatment failure. This research is like uncovering a hidden map in the desert, guiding us towards a better understanding of the factors that drive treatment success.

Managing Unstable Angina: Early Intervention and Risk Factors

This study highlights the importance of early intervention and considering risk factors in managing unstable angina. It emphasizes the role of calcium channel antagonists in potentially improving treatment outcomes. Think of this research as a compass, guiding us toward a better understanding of this complex condition and its management.

Dr.Camel's Conclusion

The study of unstable angina is a critical undertaking, offering valuable insights into predicting treatment success. The findings emphasize the importance of a multi-faceted approach to managing this condition, considering risk factors, early intervention, and potentially beneficial medications. As researchers, we must continue our journey through the desert of cardiovascular research, seeking to develop effective treatments and improve the lives of patients.

Date :
  1. Date Completed 1984-09-19
  2. Date Revised 2019-06-23
Further Info :

Pubmed ID

6378422

DOI: Digital Object Identifier

10.1161/01.cir.70.3.367

Related Literature

Article Analysis
・Effective treatment of angina
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.