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Combined radiotherapy-chemotherapy for early stages non-Hodgkin's lymphoma: the 1975-1980 EORTC controlled lymphoma trial.

Author: AbbatucciJ S, BurgersJ M, CardeP, CossetJ M, HayatM, LefurR, QasimM M, SizooW, SomersR, van GlabbekeM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

In patients with stage I and II non-Hodgkin's lymphoma, extended field radiotherapy with adjuvant cyclophosphamide, vincristine, prednisone (CVP) chemotherapy resulted in higher relapse-free survival but not overall survival compared to radiotherapy alone. Patients with diffuse histologies had lower relapse-free survival than those with follicular histologies, and adjuvant CVP did not improve survival in this group. Stage II patients with follicular histologies showed good results, while diffuse histologies required new therapeutic strategies.
Paper Details　
Original Abstract of the Article :
Patients with stage I and II non-Hodgkin's lymphoma (NHL) are considered to have a relatively good prognosis. For this reason, they are seldom referred to specialized centers and the accrual of such patients in controlled studies is limited. Therefore, significant studies of homogeneously treated pa...See full text at original site
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引用元：
https://doi.org/10.1016/s0167-8140(84)80072-9

データ提供：米国国立医学図書館（NLM）

Unraveling the Complexities of Non-Hodgkin's Lymphoma Treatment

The battle against [non-Hodgkin's lymphoma (NHL)] is an ongoing quest, with researchers constantly seeking optimal treatment strategies. This study examines the effectiveness of [combined radiotherapy-chemotherapy] in patients with [early stages of NHL]. The study aims to determine the [prognostic value of histologic classifications] and compare the effectiveness of different treatment options within each stage.

A Balancing Act: Radiotherapy and Chemotherapy for NHL

The research findings revealed that [adjuvant chemotherapy] improved [relapse-free survival] in patients with [stage I NHL], while [total nodal irradiation] demonstrated a positive but not statistically significant advantage in [stage II NHL]. The study also highlighted the importance of [histologic type] in predicting treatment outcomes, underscoring the need for personalized approaches to NHL treatment.

Navigating the Path to Recovery: A Multi-faceted Approach

The study's findings emphasize the critical role of [histopathology] and [staging procedures] in guiding treatment decisions. It also highlights the need for ongoing research to refine treatment strategies and improve outcomes for patients with NHL. The exploration of [alternating radiotherapy and chemotherapy] as a potential alternative treatment approach for [diffuse histologies] offers a promising direction for future research.

Dr.Camel's Conclusion

This research is like navigating a vast desert landscape. Just as a traveler must adapt to the changing terrain, doctors must tailor treatment plans based on the unique characteristics of each patient's NHL. Understanding the nuances of this disease and its various subtypes is crucial for maximizing treatment success and improving patient outcomes. The quest to find the best path through the desert of NHL continues, but with each study, we get closer to our destination.

Date :
  1. Date Completed 1985-03-19
  2. Date Revised 2019-08-29
Further Info :

Pubmed ID

6395212

DOI: Digital Object Identifier

10.1016/s0167-8140(84)80072-9

Related Literature

Article Analysis
・Effective treatment of lymphoma
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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