Effective treatment of lymphoma: A Synthesis of Findings from 43 Studies

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Original Abstract of the Article

Major Research Findings

The research on lymphoma treatment has made significant progress, with various chemotherapy regimens and approaches being explored. 17 found no significant difference in overall survival between the standard CHOP regimen (cyclophosphamide, doxorubicin, vincristine, and prednisone) and third-generation chemotherapy regimens, suggesting CHOP remains a viable option. 23 highlighted the effectiveness of rituximab-containing treatments for relapsed diffuse large B-cell lymphoma. suggests tisagenlecleucel (CAR-T cell therapy) as a potential treatment for extending survival in patients with aggressive lymphoma.

13 showed the effectiveness of combining radiotherapy and chemotherapy for early-stage non-Hodgkin's lymphoma. indicated that chemotherapy remains the primary treatment for childhood non-Hodgkin's lymphoma, with improved outcomes in recent years. 41 emphasizes the emergence of CAR-T cell therapy as a promising new treatment option for relapsed or refractory diffuse large B-cell lymphoma.

3 compared chemotherapy (cyclophosphamide, vincristine, and prednisone) and radiotherapy (total body irradiation) for stage III-IV poorly differentiated lymphocytic lymphoma. 25 established chemotherapy followed by localized radiotherapy as the standard treatment for early-stage Hodgkin lymphoma. 38 discusses the use of chemotherapy and radiotherapy for primary mediastinal B-cell lymphoma, emphasizing the need to consider long-term treatment-related morbidity. PET/CT scans can help determine which patients might benefit from additional therapies.

12 found that chemotherapy is effective for primary digestive non-Hodgkin's lymphoma. 33 explores the use of a lymphoma nurse-led model of survivorship care to address the long-term effects of lymphoma treatment. 35 critically reviews the methodology of clinical trials evaluating the incorporation of new drugs in first-line treatment for diffuse large B-cell lymphoma.

19 systematically reviews chemotherapy effects in indolent non-Hodgkin's lymphoma, including its benefits and side effects. 30 suggests high-dose chemotherapy followed by autologous stem cell transplantation as a viable treatment for relapsed/refractory Hodgkin lymphoma. 22 examines the potential of gemcitabine for treating relapsed or refractory diffuse large B-cell lymphoma in elderly patients.

21 highlights the importance of doxorubicin dose intensity in predicting survival for patients with aggressive non-Hodgkin's lymphoma. provides a meta-analysis on adverse events associated with radioimmunotherapy for non-Hodgkin's lymphoma. 43 conducts a meta-analysis investigating the effectiveness of autologous stem cell transplantation as first-line treatment for nodal peripheral T-cell lymphoma.

7 shows that maintenance therapy can help control large-cell non-Hodgkin's lymphoma after initial remission. 20 explores the long-term non-neoplastic events in patients with aggressive non-Hodgkin's lymphoma. 34 reiterates the standard treatment for early-stage Hodgkin lymphoma as a combination of chemotherapy followed by localized radiotherapy.

32 examines the potential for omitting radiotherapy in early-stage Hodgkin lymphoma based on PET scan results. 8 discusses prognostic factors and treatment strategies for diffuse large cell lymphoma. 11 reports on the findings of an EORTC trial for non-Hodgkin's lymphoma.

16 found that surgery combined with chemotherapy was effective for primary non-Hodgkin's lymphoma of the stomach. 14 compares three treatment options for advanced-stage favorable histology non-Hodgkin's lymphoma: single agent chemotherapy, combination chemotherapy, and whole body irradiation. 1 presents findings from an O.E.R.T.C. study on the treatment of non-Hodgkin's lymphoma.

18 indicates that a nine-week chemotherapy regimen without radiotherapy can be adequate for most children and young adults with early-stage, nonlymphoblastic non-Hodgkin's lymphoma. 31 explores the potential of antibody therapies for lymphoma in children. 9 compares a watchful waiting approach with aggressive combined modality treatment for patients with advanced indolent lymphoma.

27 suggests that omitting radiotherapy in early-stage Hodgkin lymphoma might be possible. 15 compares the effectiveness of epidoxorubicin and idarubicin containing regimens in treating intermediate and high grade non-Hodgkin's lymphoma.

Treatment Summary

Lymphoma treatment options vary based on lymphoma type, stage, patient age, and overall health. However, chemotherapy often plays a central role. Recent years have seen the emergence of new treatments like CAR-T cell therapy and radioimmunotherapy, expanding the options for patients who haven't benefited from traditional treatments. 23 suggests that rituximab is effective for relapsed diffuse large B-cell lymphoma.

Radiotherapy is sometimes combined with chemotherapy for early-stage lymphoma. 27 suggests that omitting radiotherapy in early-stage Hodgkin lymphoma might be possible.

Choosing the right treatment plan for each patient is crucial, necessitating close collaboration between the patient and their physician. Understanding the treatment plan is essential for optimal treatment outcomes.

Benefits and Risks

Benefits Summary

Lymphoma treatment has advanced significantly, improving survival rates for many patients. The emergence of new treatment options offers a broader range of choices, allowing for personalized treatment based on individual needs, potentially leading to better treatment outcomes and reduced side effects.

Risks Summary

Lymphoma treatment involves a range of methods, including chemotherapy and radiotherapy, each carrying its own set of potential side effects. Side effects vary depending on the treatment type, dosage, and patient health. Common side effects include nausea, vomiting, hair loss, bone marrow suppression, infections, heart problems, and infertility. While many side effects subside within weeks or months after treatment, some can persist long-term.

Comparison of Studies

Commonalities

Many studies demonstrate the effectiveness of chemotherapy in treating lymphoma. Research consistently highlights the influence of factors like lymphoma type, stage, patient age, and health status on treatment outcomes.

Differences

Studies differ in the specific types and dosages of chemotherapy used, the inclusion or exclusion of radiotherapy, the size of the study, and the characteristics of the patient population. These variations make comparing results challenging.

Consistency and Discrepancies in Findings

While research on lymphoma treatment is growing, findings can be both consistent and conflicting. This variability could stem from differences in research methodologies and patient characteristics. Thorough consideration of these factors is crucial for interpreting study results.

Applying Research Findings to Real Life

Lymphoma treatment choices must be tailored to each patient's unique situation. Open communication with a physician is essential for understanding treatment options and making informed decisions. Regular checkups as directed by the physician are important during treatment.

Limitations of Current Research

Despite the increasing research on lymphoma treatment, there are ongoing challenges. For example, research is needed to develop new treatment options and further investigate the effectiveness of existing therapies. Research on lymphoma prevention and early detection is also vital.

Future Research Directions

Continued research on lymphoma treatment is crucial. Specifically, research should focus on developing new treatments, better understanding the effectiveness of existing therapies, and investigating ways to prevent and detect lymphoma early.

Conclusion

Lymphoma treatment has advanced significantly, leading to improved survival rates for many patients. However, ongoing challenges require continued research efforts. When considering lymphoma treatment, open communication with your doctor and understanding your treatment plan are key to achieving the best possible outcomes.

Treatment List

Chemotherapy, Radiotherapy, CAR-T cell therapy, Radioimmunotherapy, Autologous stem cell transplant

Keywords
Benefit Keywords
Lymphomas treatment
1
Improved remission rate for lymphocytic lymphoma
Improved survival for lymphocytic lymphoma
2
Effective lymphoma treatment
Improved survival for lymphoma
Improved tolerance
3
Excellent responses
Prolonged survival
4
NHL treatment
5
Lymphoma treatment
Survival improvement
6
Lymphoma treatment
Remission duration improvement
7
Lymphoma treatment
8
Indolent lymphoma treatment
9
Complete remission
Improved survival
10
Improved disease-free survival
Improved survival
11
Complete remission
Improved survival
12
NHL treatment
13
Lymphoma survival
14
Improved response duration
Improved response rate
15
Improved survival
16
Lymphoma treatment
17
Improved survival
Simplified therapy
18
Indolent NHL treatment
19
Long-term survival
20
NHL treatment
21
NHL treatment
22
Response rates
Survival benefit
23
Improved lymphoma survival
24
Hodgkin lymphoma treatment
25
Improved overall survival
27
Improved PFS rates
28
Follicular lymphoma treatment
29
HL treatment
30
Paediatric lymphoma treatment
31
HL treatment
32
Improved quality of life
33
Hodgkin lymphoma treatment
34
Improved DLBCL treatment
35
Improved survival
36
Improved PTCL treatment
37
RIT for NHL
39
Increased survival
40
CAR T-cell therapy
DLBCL treatment
41
Lymphoma treatment
42
Improved nodal PTCL treatment
43
Risk Keywords
Infection
Myeloproliferative disorder
Neurotoxicity
3
Toxicity
6
Toxicity
7
Infection
Neutropenia
Sepsis
10
Higher cost
Higher toxicity
17
Inferior survival for lymphoblastic lymphoma
Side effects
18
Late complications
20
Economic limitations
21
Sexual dysfunction
24
Secondary malignancies
25
Death from other causes
27
Increased risk of second cancers
28
Neutropenia
Second malignancies
29
Long-term effects
33
Late sequelae
36
Association with second neoplasms
39
Comorbidities
Falls
40
Adverse events
42
Literature analysis of 43 papers
Positive Content
43
Neutral Content
0
Negative Content
0
Article Type
25
11
16
13
43
1.

[O.E.R.T.C. study on the treatment of non-Hodgkin's lymphomas: origin-aims-means (author's transl)].

Author: Le BourgeoisJ P

Lymphomas treatment

A study of patients with non-Hodgkin's lymphoma evaluated various treatment strategies based on disease stage. Stage I patients received primary radiation therapy, while stage II patients received radiation therapy followed by maintenance chemotherapy. Stage III and IV patients received induction chemotherapy followed by maintenance chemotherapy, with additional radiation for certain subgroups. The study aimed to compare different chemotherapy regimens and evaluate the role of radiation therapy in various stages of non-Hodgkin's lymphoma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

2.

Combination versus successive single agent chemotherapy in lymphocytic lymphoma.

Author: KennedyB J, BloomfieldC D, KiangD T, VosikaG, PetersonB A, TheologidesA

Improved remission rate for lymphocytic lymphoma
Improved survival for lymphocytic lymphoma

A study of 53 patients with advanced lymphocytic lymphoma compared two chemotherapy regimens: a combination of cyclophosphamide, vincristine, and prednisone (CVP) and the same drugs used sequentially (C-V-P). CVP achieved a significantly higher complete remission rate (68%) compared to C-V-P (48%), particularly in patients with nodular lymphoma (81% vs. 46%). Patients achieving complete remission with CVP also had longer remission durations (37+ months) compared to C-V-P (25+ months). The study suggests that CVP is a better initial treatment for nodular lymphoma, but that neither regimen is highly effective for diffuse lymphocytic lymphoma. More effective therapies are needed for this type of lymphoma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

3.

Chemotherapy (cyclophosphamide, vincristine, and prednisone) versus radiotherapy (total body irradiation) for stage III-IV poorly differentiated lymphocytic lymphoma.

Author: JohnsonR E, CanellosG P, YoungR C, ChabnerB A, DeVitaV T

Effective lymphoma treatment
Improved survival for lymphoma
Improved tolerance
Infection
Myeloproliferative disorder
Neurotoxicity

A study of 72 patients with advanced poorly differentiated lymphocytic (PDL) lymphoma compared the effectiveness of initial chemotherapy (CVP) and total body irradiation (TBI). Both treatments were equally effective in patients with nodular PDL, with 7-year survival rates of 66% and 67%, respectively. TBI resulted in better initial response and shorter-term survival in patients with diffuse PDL, but there was no long-term survival advantage (5-year survival rate of 28% for TBI and 25% for CVP). TBI was better tolerated than CVP, with fewer patients experiencing treatment-related complications. However, both treatment approaches yielded low rates of long-term remission, suggesting the need for new therapies for PDL lymphoma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Treatment of advanced non-Hodgkin's lymphomas with favorable histologies: preliminary results of a prospective trial.

Author: PortlockC S, RosenbergS A, GlatsteinE, KaplanH S

Excellent responses
Prolonged survival

A study of 63 patients with stage IV non-Hodgkin's lymphoma compared three treatment regimens: CVP (cyclophosphamide, vincristine, and prednisone), CVP with total lymphoid irradiation (CVP-TLI), and a single alkylating agent (SA). All three regimens achieved a high response rate (over 95%), with complete remission rates of 78.3% for CVP, 65% for CVP-TLI, and 55% for SA. While the probability of achieving complete remission was similar between the groups, SA patients took longer to reach remission. Relapse rates were low across all groups, with no significant differences in survival or disease-free survival. The study concludes that all three regimens were highly effective in treating stage IV non-Hodgkin's lymphoma with favorable histology, with single-agent therapy showing comparable long-term survival to the more intensive regimens.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

5.

Non-Hodgkin's lymphomas in children. II. Treatment.

Author: WhiteL, SiegelS E, QuahT C

NHL treatment

The prognosis of childhood non-Hodgkin's lymphoma (NHL) has improved with effective chemotherapy regimens tailored to prognostic categories. Surgery is beneficial only when near-total resection is possible. Radiation therapy is limited to specific situations. Intrathecal and systemic chemotherapy are effective for CNS lymphoma prevention. While lymphoblastic lymphoma has high cure rates, non-localized non-lymphoblastic disease remains challenging. Localized NHL has high cure rates with short chemotherapy regimens.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

[Preinduction in the treatment of patients with malignant lymphoma].

Author: AvilésA, GarcíaE L, TalaveraA, GuzmánR, Diáz-MaqueoJ C

Lymphoma treatment
Survival improvement
Toxicity

This study of 98 patients with malignant lymphoma compared the effectiveness of a preinduction regimen of low-dose methotrexate followed by standard chemotherapy (CHOP-Bleo) to standard chemotherapy alone. The preinduction group had fewer early deaths, a higher complete remission rate, longer remission duration, and better overall survival compared to the conventional chemotherapy group. While the preinduction regimen had acceptable side effects, the severity of side effects was similar in both groups receiving standard chemotherapy. The study suggests that a preinduction regimen of low-dose methotrexate is a beneficial approach for patients with malignant lymphoma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Spanish

7.

The role of maintenance therapy in the treatment of large-cell non-Hodgkin's lymphoma.

Author: AvilésA, HuertaJ, ZepedaG, GuzmánR, Díaz-MaqueoJ

Lymphoma treatment
Remission duration improvement
Toxicity

This study of 81 patients with large-cell non-Hodgkin's lymphoma who achieved complete remission after initial chemotherapy compared three treatment approaches: observation, early consolidation therapy, and maintenance therapy. The study found that both consolidation and maintenance therapy resulted in better relapse-free survival than observation alone. While these additional treatments were effective in controlling the disease with acceptable side effects, the authors suggest that more aggressive, toxic treatments are not necessary initially because maintenance therapy can effectively extend remission using less intense, less toxic regimens.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Diffuse large cell lymphoma. Prognostic factors with treatment.

Author: StrausD J, WongG, YahalomJ, VarsosG, GulatiS, ClarksonB

Lymphoma treatment

Five different chemotherapy regimens for advanced diffuse large cell lymphoma (DLCL) resulted in similar overall survival rates, with 35-45% of patients surviving. Factors associated with shorter survival included extensive disease, high LDH levels, and older age. In younger patients with advanced disease and high LDH levels, a combination of high-dose chemotherapy, radiation therapy, and bone marrow transplant showed more promising results. In a separate study, radiation therapy followed by chemotherapy was more effective than radiation alone for early-stage diffuse lymphoma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

The treatment of indolent lymphomas: watchful waiting v aggressive combined modality treatment.

Author: YoungR C, LongoD L, GlatsteinE, IhdeD C, JaffeE S, DeVitaV T

Indolent lymphoma treatment

This study compared two approaches for treating advanced indolent lymphoma: "watch and wait" with limited radiation therapy as needed and aggressive combination chemotherapy followed by radiation. While 56% of the "watch and wait" group remained free of systemic treatment after 34 months, 82% of the chemotherapy group completed treatment and achieved remission. The study suggests that an aggressive treatment approach may be more effective in controlling indolent lymphoma, but more research is needed to determine the optimal strategy for managing this type of cancer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

LNH-84 regimen: a multicenter study of intensive chemotherapy in 737 patients with aggressive malignant lymphoma.

Author: CoiffierB, GisselbrechtC, HerbrechtR, TillyH, BoslyA, BrousseN

Complete remission
Improved survival
Infection
Neutropenia
Sepsis

This study investigated the effectiveness of an intensive chemotherapy regimen (LNH-84) in treating 737 patients with aggressive lymphoma. The study found that 75% of patients achieved complete remission. The 2-year survival rate was 67%, with a similar rate of relapse regardless of whether patients received an additional intensification treatment. While the treatment was effective, it was associated with significant side effects, including low white blood cell counts, fever, and infections. The study concludes that the LNH-84 regimen is an effective treatment for aggressive lymphoma, but further research is needed to improve treatment strategies and reduce side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

EORTC trial non-Hodgkin lymphomas.

Author: SomersR, BurgersJ M, QasimM, Van GlabbekeM, DuezN, HayatM

Improved disease-free survival
Improved survival

A study of 468 patients with non-Hodgkin lymphoma found that treatment effectiveness varied based on stage and histological subtype. Maintenance chemotherapy after regional radiotherapy did not significantly improve survival for stage I patients but did improve disease-free survival. Chemotherapy regimens for stage III and IV patients did not differ in effectiveness, and patients with follicular lymphoma had better long-term outcomes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

[Results of a cooperative prospective study of treatment of primary digestive localizations of non-Hodgkin's lymphoma].

Author: ParlierY, NajmanA, LecomteD, AegerterP

Complete remission
Improved survival

A study of 82 patients with primary digestive lymphoma found that chemotherapy was effective, resulting in a 63% complete remission rate. Survival at 5 years was 46%. Factors influencing survival included the extent of the disease, tumor grade, initial location (gastric lymphoma had the best survival), and achievement of complete remission. While chemotherapy was effective, the role of surgery in managing lymphomas requires further investigation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

13.

Combined radiotherapy-chemotherapy for early stages non-Hodgkin's lymphoma: the 1975-1980 EORTC controlled lymphoma trial.

Author: CardeP, BurgersJ M, van GlabbekeM, HayatM, CossetJ M, SomersR, SizooW, QasimM M, LefurR, AbbatucciJ S

NHL treatment

In patients with stage I and II non-Hodgkin's lymphoma, extended field radiotherapy with adjuvant cyclophosphamide, vincristine, prednisone (CVP) chemotherapy resulted in higher relapse-free survival but not overall survival compared to radiotherapy alone. Patients with diffuse histologies had lower relapse-free survival than those with follicular histologies, and adjuvant CVP did not improve survival in this group. Stage II patients with follicular histologies showed good results, while diffuse histologies required new therapeutic strategies.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

The treatment of advanced stage favorable histology non-Hodgkin's lymphoma: a preliminary report of a randomized trial comparing single agent chemotherapy, combination chemotherapy, and whole body irradiation.

Author: HoppeR T, KushlanP, KaplanH S, RosenbergS A, BrownB W

Lymphoma survival

This study of 51 patients with non-Hodgkin's lymphoma found that all three treatment options (single alkylating agent chemotherapy, combination chemotherapy with CVP, or fractionated whole body irradiation followed by low dose involved field irradiation) had similar survival rates at 4 years (84%). While initial complete remission rates were similar, relapse was frequent, with only 25% of patients remaining relapse-free at 4 years. CVP was associated with the most acute complications, while whole body irradiation was associated with the most long-term hematologic depression.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

15.

Epidoxorubicin vs idarubicin containing regimens in intermediate and high grade non-Hodgkin's lymphoma: preliminary results of a multicentric randomized trial.

Author: BrugiatelliM, FedericoM, GobbiP G, AvanziniP, CalleaV, CavannaL, De PasqualeA, Di PriscoA U, Di RienzoN, SilingardiV

Improved response duration
Improved response rate

This report describes a prospective randomized trial on the treatment of aggressive and advanced non-Hodgkin's lymphoma (NHL) by the Italian Lymphoma Study Group (GISL), focusing on the efficacy of two Pro-MACE-CytaBom (P-C) derived protocols.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Primary non-Hodgkin's lymphoma of the stomach: three radical modalities of treatment in 75 patients.

Author: ShchepotinI B, EvansS R, ShabahangM, ChornyV, BurasR R, KorobkoV, ZadorozhnyA, NautaR J

Improved survival

A combination of preoperative radiation, surgery, and postoperative chemotherapy resulted in improved survival for patients with gastric Non-Hodgkin's lymphoma (NHL) compared to surgery alone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Cyclophosphamide, doxorubicin, vincristine, and prednisone versus intensive chemotherapy in non-Hodgkin's lymphoma.

Author: FisherR I

Lymphoma treatment
Higher cost
Higher toxicity

This study reviewed the evolution of therapy for aggressive non-Hodgkin's lymphomas and compared the efficacy of standard therapy (CHOP) to third-generation chemotherapy regimens (m-BACOD, ProMACE-CytaBOM, and MACOP-B). The study found no significant difference in response rate, progression-free survival, or overall survival between the groups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Treatment of children and young adults with early-stage non-Hodgkin's lymphoma.

Author: LinkM P, ShusterJ J, DonaldsonS S, BerardC W, MurphyS B

Improved survival
Simplified therapy
Inferior survival for lymphoblastic lymphoma
Side effects

A 9-week chemotherapy regimen without radiation was adequate for most children and young adults with early-stage, nonlymphoblastic non-Hodgkin's lymphoma, with a 5-year continuous complete remission rate of 89%.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

19.

A systematic overview of chemotherapy effects in indolent non-Hodgkin's lymphoma.

Author: BrandtL, KimbyE, NygrenP, GlimeliusB,

Indolent NHL treatment

This review of chemotherapy trials in several tumor types found that chemotherapy is useful in palliative treatment of advanced indolent non-Hodgkin's lymphoma and can result in improved well-being for most patients. However, chemotherapy has not convincingly resulted in longer remissions or proven to prolong survival.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

20.

Late non-neoplastic events in patients with aggressive non-Hodgkin's lymphoma in four randomized European Organisation for Research and Treatment of Cancer trials.

Author: MoserElizabeth C, NoordijkEvert M, CardePatrice, TirelliUmberto, BaarsJoke W, ThomasJose, BronDominique, MeerwaldtJacobus H, van GlabbekeMartine, RaemaekersJohn M M, Kluin-NelemansHanneke C

Long-term survival
Late complications

This study investigates late complications in a European Organisation for Research and Treatment of Cancer database of patients with aggressive non-Hodgkin's lymphoma (NHL) who have achieved long-term survival.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

High dose intensity doxorubicin in aggressive non-Hodgkin's lymphoma: a literature-based meta-analysis.

Author: AzimH A, SantoroL, BociekR G, GandiniS, MalekR A

NHL treatment
Economic limitations

This study discusses the standard chemotherapy regimen for aggressive non-Hodgkin's lymphoma (NHL), which includes cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP). It highlights the importance of rituximab in treating B-cell NHL but also discusses the limitations of access to rituximab due to cost.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

22.

Gemcitabine and treatment of diffuse large B-cell lymphoma in relapsed or refractory elderly patients: a prospective randomized trial in Algeria.

Author: AribiMourad, MesliNaima, RemlaNesrine, SariBadr-Eddine, TalebAbdesselam, TouhamiHadj, BekadjaMohamed-Amine, Zouaoui-BenhadjiZahia, BouzidKamel, MeguenniKaoual

NHL treatment

This article discusses the challenges of treating non-Hodgkin's lymphoma (NHL) with large cells that is refractory or relapsed after first-line chemotherapy, particularly in developing countries.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

Salvage regimens with autologous transplantation for relapsed large B-cell lymphoma in the rituximab era.

Author: GisselbrechtChristian, GlassBertram, MounierNicolas, Singh GillDevinder, LinchDavid C, TrnenyMarek, BoslyAndre, KettererNicolas, ShpilbergOfer, HagbergHans, MaDavid, BrièreJosette, MoskowitzCraig H, SchmitzNorbert

Response rates
Survival benefit

Rituximab, ifosfamide, etoposide, and carboplatin (R-ICE) and rituximab, dexamethasone, high-dose cytarabine, and cisplatin (R-DHAP) showed similar response rates in patients with relapsed diffuse large B-cell lymphoma. Early relapses after rituximab-containing first-line therapy had a poor prognosis, with no significant difference between R-ICE and R-DHAP.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Sexual functioning in male survivors of lymphoma: a systematic review (CME).

Author: Arden-CloseEmily, EiserChristine, PaceyAllan

Improved lymphoma survival
Sexual dysfunction

This study discusses the impact of lymphoma treatment, specifically Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL), on sexual dysfunction and quality of life (QoL) in men under 45 years.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

Chemotherapy alone versus chemotherapy plus radiotherapy for early stage Hodgkin lymphoma.

Author: HerbstChristine, RehanFareed Ahmed, SkoetzNicole, BohliusJulia, BrillantCorinne, SchulzHolger, MonsefIna, SpechtLena, EngertAndreas

Hodgkin lymphoma treatment
Secondary malignancies

While combined chemotherapy and radiation therapy (CMT) is the standard treatment for early-stage Hodgkin lymphoma (HL), the role of radiation is being questioned due to long-term side effects like secondary cancers. Some studies suggest that chemotherapy alone may be sufficient for this stage of the disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

Therapeutic interventions for Burkitt lymphoma in children.

Author: OkebeJoseph U, SkoetzNicole, MeremikwuMartin M, RichardsSue

This review assessed the evidence for chemotherapy, surgery, radiotherapy, and immunotherapy in the treatment of children with endemic Burkitt lymphoma. While less aggressive treatment schedules appear to produce similar effects with fewer adverse events, the evidence for the relative effectiveness of interventions is not strong due to the small size, underpowering, and methodological limitations of the included trials.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
CommentA short article/note that provides an opinion/perspective/interpretation on a published paper/topic.

Language : English

27.

ABVD alone versus radiation-based therapy in limited-stage Hodgkin's lymphoma.

Author: MeyerRalph M, GospodarowiczMary K, ConnorsJoseph M, PearceyRobert G, WellsWoodrow A, WinterJane N, HorningSandra J, DarA Rashid, ShustikChaim, StewartDouglas A, CrumpMichael, DjurfeldtMarina S, ChenBingshu E, ShepherdLois E,

Improved overall survival
Death from other causes

Among patients with Hodgkin’s lymphoma, ABVD chemotherapy alone was associated with a higher rate of overall survival (94%) compared to treatment with subtotal nodal radiation therapy (87%). The higher survival rate was due to a lower rate of death from other causes.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

High-dose therapy with autologous stem cell transplantation versus chemotherapy or immuno-chemotherapy for follicular lymphoma in adults.

Author: SchaafMarkus, ReiserMarcel, BorchmannPeter, EngertAndreas, SkoetzNicole

Improved PFS rates
Increased risk of second cancers

High-dose therapy (HDT) followed by autologous stem cell transplantation (ASCT) is an option for patients with follicular lymphoma (FL) in advanced stages or for second-line therapy. While it improves progression-free survival (PFS), there is a potential for increased risk of second cancers.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

29.

R-CVP versus R-CHOP versus R-FM for the initial treatment of patients with advanced-stage follicular lymphoma: results of the FOLL05 trial conducted by the Fondazione Italiana Linfomi.

Author: FedericoMassimo, LuminariStefano, DondiAlessandra, TucciAlessandra, VitoloUmberto, RigacciLuigi, Di RaimondoFrancesco, CarellaAngelo Michele, PulsoniAlessandro, MerliFrancesco, ArcainiLuca, AngrilliFrancesco, StelitanoCaterina, GaidanoGianluca, Dell'olioMatteo, MarcheselliLuigi, FrancoVito, GalimbertiSara, SacchiStefano, BrugiatelliMaura

Follicular lymphoma treatment
Neutropenia
Second malignancies

Rituximab combined with CHOP or FM was superior to rituximab combined with CVP in terms of 3-year time to treatment failure and progression-free survival. R-CHOP had a better risk-benefit ratio compared to R-FM.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

30.

High-dose chemotherapy followed by autologous stem cell transplantation for patients with relapsed/refractory Hodgkin lymphoma.

Author: RanceaMichaela, MonsefIna, von TresckowBastian, EngertAndreas, SkoetzNicole

HL treatment

Hodgkin lymphoma (HL) is a common cancer in young adults and is curable for most people, even in advanced stages. However, about 15-20% don't respond to initial treatment and experience a relapse. For these patients, a common treatment is high-dose chemotherapy followed by a stem cell transplant.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

31.

Antibody therapies for lymphoma in children.

Author: de ZwartVerena, GouwSamantha C, Meyer-WentrupFriederike A G

Paediatric lymphoma treatment

Lymphoma is a common cancer in children, with high cure rates, but further improvements are needed. While antibody therapies have been successful for adults with lymphoma, none are currently approved for children.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

32.

PET-adapted omission of radiotherapy in early stage Hodgkin lymphoma-a systematic review and meta-analysis.

Author: SickingerMarie T, von TresckowBastian, KobeCarsten, BorchmannPeter, EngertAndreas, SkoetzNicole

HL treatment

Hodgkin lymphoma (HL) is a common cancer in young adults and is highly curable. Treatment for HL is being adjusted based on a scan called a PET scan, which is done during treatment. A negative PET scan indicates good response, while a positive scan means the treatment isn't working as well. This is leading to research on giving less or more aggressive treatment based on the PET scan results.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

33.

Protocol for Care After Lymphoma (CALy) trial: a phase II pilot randomised controlled trial of a lymphoma nurse-led model of survivorship care.

Author: TaylorKaren, JoskeDavid, BulsaraMax, BulsaraCaroline, MonterossoLeanne

Improved quality of life
Long-term effects

This study focuses on the long-term effects of lymphoma treatment on quality of life. With increasing survival rates for lymphoma, the study emphasizes the importance of addressing the complex needs of survivors, who often face significant challenges.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

34.

Chemotherapy alone versus chemotherapy plus radiotherapy for adults with early stage Hodgkin lymphoma.

Author: BlankOliver, von TresckowBastian, MonsefIna, SpechtLena, EngertAndreas, SkoetzNicole

Hodgkin lymphoma treatment

The standard treatment for early-stage Hodgkin lymphoma (HL) is a combination of chemotherapy and radiation. However, the use of radiation is being questioned due to potential long-term side effects, such as new cancers. Some groups are now advocating for using only chemotherapy for this type of cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

35.

Methodology of clinical trials evaluating the incorporation of new drugs in the first-line treatment of patients with diffuse large B-cell lymphoma (DLBCL): a critical review.

Author: IacoboniG, ZuccaE, GhielminiM, StathisA

Improved DLBCL treatment

This study discussed the current standard treatment for diffuse large B-cell lymphoma (DLBCL), combining rituximab with CHOP chemotherapy, and explored the potential for improving treatment outcomes through ongoing clinical trials.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

36.

Hodgkin Lymphoma in Adults.

Author: BröckelmannPaul J, EichenauerDennis A, JakobTina, FollmannMarkus, EngertAndreas, SkoetzNicole

Improved survival
Late sequelae

The use of positron emission tomography (PET) is recommended in the initial diagnostic evaluation and for the guidance of treatment in advanced stages of Hodgkin lymphoma. The five-year survival of patients with Hodgkin lymphoma is 95%.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

37.

Contemporary strategies to improve outcomes for peripheral T-cell lymphoma patients following the failure of first-line therapy.

Author: KallamAvyakta, ArmitageJames O

Improved PTCL treatment

This study examined the challenges of treating T cell lymphomas, highlighting the need for further research to improve treatment outcomes and reduce relapse rates.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

38.

Primary Mediastinal B Cell Lymphoma in the Positron-Emission Tomography Era Executive Summary of the American Radium Society Appropriate Use Criteria.

Author: HoppeBradford S, AdvaniRanjana, MilgromSarah A, BakstRichard L, BallasLeslie K, DabajaBouthaina S, FlowersChristopher R, HaChul S, MansurDavid B, MetzgerMonika L, PinnixChelsea C, PlastarasJohn P, RobertsKenneth B, SmithSonali M, TerezakisStephanie A, KirwanJessica M, ConstineLouis S

Primary mediastinal B cell lymphoma is highly curable, with treatment strategies including chemoimmunotherapy and radiation therapy. Adaptive approaches using end-of-chemotherapy PET/CT scanning can help determine which patients require additional therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

39.

Adverse events of radioimmunotherapy for non-Hodgkin lymphoma: A systematic review and meta-analysis.

Author: ShardaEsha, PatelRaahil S, Juárez-SalcedoLuis Miguel, DaliaSamir, HannaCatherine H, GruhonjicHanan, PonnagantiBharat S, MhaskarRahul

RIT for NHL
Association with second neoplasms

This meta-analysis evaluated the association between radioimmunotherapy (RIT) and the development of second neoplasms, specifically acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS), in patients with non-Hodgkin's lymphoma (NHL). While RIT shows promise in treating NHL, this study aimed to determine the safety of the therapy by assessing the incidence of these secondary cancers.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

40.

Impact of therapeutic management and geriatric evaluation on patient of eighty years and older with diffuse large B-cell lymphoma on survival: A systematic review.

Author: BriandMarguerite, GerardStephane, GauthierMartin, GarricMarie, SteinmeyerZara, BalardyLaurent

Increased survival
Comorbidities
Falls

This systematic review investigated the impact of therapeutics management and geriatric evaluation on survival in aged patients with diffuse large B cell lymphoma (DLBCL). The review found that chemoimmunotherapy with anthracyclines increased survival in selected very elderly patients compared with less intensive regimens. Geriatric assessment, particularly altered mobility disorders and severe comorbidities, was predictive of survival.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

41.

Chimeric antigen receptor (CAR) T-cell therapy for people with relapsed or refractory diffuse large B-cell lymphoma.

Author: ErnstMoritz, OeserAnnika, BesirogluBurcu, Caro-ValenzuelaJulia, Abd El AzizMohamed, MonsefIna, BorchmannPeter, EstcourtLise J, SkoetzNicole, GoldkuhleMarius

CAR T-cell therapy
DLBCL treatment

Chimeric antigen receptor (CAR) T-cell therapy has emerged as a novel treatment option for individuals with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) who are ineligible for autologous stem-cell transplantation (ASCT).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

42.

Second-Line Tisagenlecleucel or Standard Care in Aggressive B-Cell Lymphoma.

Author: BishopMichael R, DickinsonMichael, PurtillDuncan, BarbaPere, SantoroArmando, HamadNada, KatoKoji, SuredaAnna, GreilRichard, ThieblemontCatherine, MorschhauserFranck, JanzMartin, FlinnIan, RabitschWerner, KwongYok-Lam, KerstenMarie J, MinnemaMonique C, HolteHarald, ChanEsther H L, Martinez-LopezJoaquin, MüllerAntonia M S, MaziarzRichard T, McGuirkJoseph P, BachyEmmanuel, Le GouillSteven, DreylingMartin, HarigaeHideo, BondDavid, AndreadisCharalambos, McSweeneyPeter, Kharfan-DabajaMohamed, NewsomeSimon, DegtyarevEvgeny, AwasthiRakesh, Del CorralChristopher, AndreolaGiovanna, MasoodAisha, SchusterStephen J, JägerUlrich, BorchmannPeter, WestinJason R

Lymphoma treatment
Adverse events

This phase 3 trial compared tisagenlecleucel with standard salvage therapy for aggressive lymphoma refractory to or progressing within 12 months after first-line therapy. There was no significant difference in event-free survival between the groups. Further research is needed to identify patients who may benefit most from each approach.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

43.

The efficiency of autologous stem cell transplantation as the first-line treatment for nodal peripheral T-cell lymphoma: results of a systematic review and meta-analysis.

Author: ZhaiYixin, WangJinhuan, JiangYanan, WuWenqi, LvYangyang, XuHong, TianLinyan, SunHuimeng, ZhaoZhigang, LiLanfang

Improved nodal PTCL treatment

This study examines the potential role of autologous stem cell transplantation (ASCT) as a first-line consolidation therapy for nodal peripheral T cell lymphoma (PTCL) patients. ASCT may offer a more favorable outcome compared to conventional chemotherapy, but further research is needed to establish a consensus on its optimal use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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