Paper Details

  1. Home
  2. Paper Details

[Are calcium inhibitors useful in the treatment of effort angina pectoris].

Author: BounhoureJ P, FauvelJ M, MiquelJ P, PuelJ, SabotG

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study compared the effects of propranolol (a beta-blocker), diltiazem (a calcium channel blocker), and placebo on exercise capacity in 10 patients with stable effort angina and significant coronary artery disease. Both propranolol and diltiazem significantly improved exercise capacity compared to placebo. Propranolol was more effective than diltiazem in 6 patients, while both drugs were equally effective in 4 patients. Combining the two drugs in a small, open-label study showed even greater benefit in 3 out of 5 patients. While the small sample size limits definitive conclusions, these results suggest that diltiazem can effectively reduce angina symptoms by decreasing myocardial oxygen consumption without impairing heart muscle function, similar to the effects of beta-blockers.
Paper Details　
Original Abstract of the Article :
Effort angina is the result of acute myocardial ischemia on exercise due to an imbalance between myocardial oxygen demand and supply. During exercise, ischemia is provoked by an increase in myocardial oxygen needs (tachycardia, increased blood pressure, etc.) which cannot be met by increased coronar...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/6407453

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 1983-07-08
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

6407453

DOI: Digital Object Identifier

6407453

Related Literature

Article Analysis
・Effective treatment of angina
SNS
PICO Info
in preparation
Languages

French

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.