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Age-related differences in kinetics and side-effects of viloxazine in man and their clinical implications.

Author: AltamuraA C, ColacurcioF, GomeniR, InvernizziG, MelorioT

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Viloxazine pharmacokinetics varied significantly with age. Older subjects had lower peak plasma values and longer half-lives. Side effects were more common in younger subjects.
Paper Details　
Original Abstract of the Article :
Dose kinetics and side effects of viloxazine (VLX) in 16 healthy volunteers (range age 25-90 years) were studied after single oral administration of 200 mg of VLX. Significant differences in peak plasma values (P less than 0.01), t1/2 (P less than 0.01) and Cl/F (P less than 0.05) were found between...See full text at original site
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引用元：
https://doi.org/10.1007/BF00427563

データ提供：米国国立医学図書館（NLM）

Viloxazine: A Journey Through Age and Pharmacology

Antidepressants are essential tools in combating mental health challenges. However, how these medications interact with our bodies can vary depending on age. This research investigated the pharmacokinetic differences in viloxazine, a type of antidepressant, between younger and older individuals. This study involved 16 healthy volunteers aged 25-90 years who received a single oral dose of viloxazine. The researchers analyzed the absorption, distribution, metabolism, and excretion of viloxazine in each participant to understand how age might influence these processes.

Imagine a caravan traversing a desert landscape. The terrain can change drastically, just like the way our bodies respond to medications over time. This research, like a careful map, aims to navigate the pharmacokinetic terrain of viloxazine across different age groups.

Age and Side Effects: A Delicate Balance

The study found significant age-related differences in the peak plasma concentrations, half-life, and clearance of viloxazine. Interestingly, older individuals experienced fewer side effects compared to younger participants. These findings highlight the importance of considering age when prescribing viloxazine and potentially adjusting dosages for optimal efficacy and safety.

Tailoring Treatment for a Changing Body

This research reminds us that our bodies age like desert sands, constantly shifting and evolving. Understanding how these changes impact drug metabolism is crucial for personalized medicine, allowing us to tailor treatment strategies to each individual's unique needs.

Dr.Camel's Conclusion

This research, like a wise camel navigating a shifting desert landscape, reminds us that age can play a significant role in the pharmacokinetics of medications. By carefully considering these factors, we can optimize treatment and ensure the best possible outcomes for individuals of all ages.

Date :
  1. Date Completed 1984-02-24
  2. Date Revised 2019-07-26
Further Info :

Pubmed ID

6419255

DOI: Digital Object Identifier

10.1007/BF00427563

Related Literature

Article Analysis
・Side Effects of viloxazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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