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Psychopharmacologic drugs in the treatment of the irritable bowel syndrome. A double blind study of the effect of trimipramine.

Author: LarsenS, LarssenS E, LövlandB, MyrenJ

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Trimipramine, an antidepressive drug, was found to have a significant beneficial effect on abdominal pain, nausea, sleeplessness, and depression in 428 patients with irritable bowel syndrome. After 6 weeks of treatment, patients reported a significant improvement in overall well-being. The only side effect was tiredness in the morning for some patients during the first two weeks.
Paper Details　
Original Abstract of the Article :
In the present multicentre double blind study of 428 patients with the irritable bowel syndrome a significant beneficial effect was found on abdominal pain, nausea, sleeplessness and depression by using 50 mg of the antidepressive drug, trimipramine, in the evening, as well as 10 mg three times dail...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/6529168

データ提供：米国国立医学図書館（NLM）

Trimipramine: A Potential Oasis for Irritable Bowel Syndrome

The world of [gastroenterology] often presents challenges akin to navigating a vast desert, where [irritable bowel syndrome (IBS)] can leave patients feeling lost and uncomfortable. This study, like a seasoned traveler seeking relief in the desert, explored the potential benefits of [trimipramine] for [treating IBS]. The researchers, using a [double-blind study] design, aimed to [evaluate the effectiveness of trimipramine in alleviating IBS symptoms]. Their findings reveal that [trimipramine demonstrated a significant positive effect on abdominal pain, nausea, sleeplessness, and depression]. This discovery offers a potential oasis for patients struggling with IBS, offering them a path to improved quality of life. The key takeaway is that [trimipramine may be an effective treatment option for patients with IBS].

Trimipramine's Soothing Effects on IBS Symptoms

The study found that [trimipramine significantly improved various symptoms of IBS], including [abdominal pain, nausea, sleeplessness, and depression]. This is like a camel discovering a refreshing oasis in the middle of a desolate desert, bringing relief and rejuvenation. These findings suggest that [trimipramine may work by modulating the brain-gut axis] and [reducing inflammation].

Navigating the Desert of IBS

This research offers a glimmer of hope for patients struggling with IBS. It's like finding a hidden spring in the desert, providing a source of comfort and relief. The findings highlight the potential for [psychotropic medications] to play a role in [managing IBS symptoms] and underscore the importance of considering the [psychological and physiological components] of this complex condition.

Dr.Camel's Conclusion

This study reminds us that even in the challenging desert of IBS, there may be hidden oases waiting to be discovered. Trimipramine offers a potential path to relief for many patients, offering a smoother and more comfortable journey through this difficult terrain.

Date :
  1. Date Completed 1985-04-19
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

6529168

DOI: Digital Object Identifier

6529168

Related Literature

Article Analysis
・Side Effects of trimipramine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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