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Treatment approaches in Gilles de la Tourette syndrome.

Author: AngL, BorisonR L, DavisJ M, DiamondB I, HamiltonW J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Haloperidol is often used to treat Tourette syndrome but has numerous side effects, including tardive dyskinesia. Fluphenazine and trifluoperazine were found to be equally effective as haloperidol with fewer side effects. Clonidine was also equally effective with fewer central nervous system side effects. Amantadine was more effective than benztropine in treating the extrapyramidal side effects of haloperidol treatment. Lithium did not significantly reduce tics.
Paper Details　
Original Abstract of the Article :
The neurological disorder Gilles de la Tourette syndrome is most often treated with the receptor blocker haloperidol, which also produces multiple side-effects, including the risk for tardive dyskinesia. In placebo control double-blind studies, two other neuroleptic drugs, fluphenazine and trifluope...See full text at original site
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引用元：
https://doi.org/10.1016/0361-9230(83)90192-2

データ提供：米国国立医学図書館（NLM）

Gilles de la Tourette Syndrome: Exploring the Neurological Desert

Gilles de la Tourette syndrome (TS) is a neurological disorder that can feel like a sandstorm in the brain. Researchers are constantly searching for effective treatments in this vast desert. This study explored various treatments for TS, including haloperidol, fluphenazine, trifluoperazine, clonidine, amantadine, benztropine, and lithium. It's like a camel caravan trying different routes to find the best way to navigate this challenging terrain. The study found that haloperidol, fluphenazine, and trifluoperazine were effective, but with significant side effects. Clonidine was found to be equally effective but with fewer adverse effects. In a crossover study, amantadine was found to be superior to benztropine in treating the side effects of haloperidol. Lithium, however, showed no significant benefit in reducing tics.

Navigating the Side Effect Dunes

This study highlights the importance of finding a treatment that balances efficacy with minimal side effects. It's like choosing a path through the desert – some routes are short but treacherous, others are long but safe. Finding the right treatment for TS is an ongoing journey for both patients and researchers.

Living with TS: A Camel's Perspective

TS can be a challenging condition, but the results of this study offer hope for more effective and less intrusive treatments. It's important to consult with a neurologist to discuss treatment options and find a path that works best for you. Just like a camel adapts to the desert, individuals with TS can learn to navigate their unique challenges.

Dr. Camel's Conclusion

This research sheds light on the diverse treatment options for TS, emphasizing the need to find a path that balances effectiveness with minimal side effects. It's like navigating the desert – finding the right route can make all the difference.

Date :
  1. Date Completed 1983-12-20
  2. Date Revised 2019-07-19
Further Info :

Pubmed ID

6578865

DOI: Digital Object Identifier

10.1016/0361-9230(83)90192-2

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・Side Effects of trifluoperazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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